Title
Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250 Team
UMMS Affiliation
Department of Pediatrics; Program in Molecular Medicine
Date
8-1998
Document Type
Article
Medical Subject Headings
Adult; Anti-HIV Agents; Cohort Studies; Female; Follow-Up Studies; HIV Infections; *HIV-1; Humans; Infant; Infant, Newborn; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; effects
Disciplines
Immunology and Infectious Disease | Pediatrics
Abstract
The safety, toxicity, and pharmacokinetics of intrapartum and early newborn nevirapine were evaluated in 17 human immunodeficiency virus type 1-infected women in labor and their newborns. No adverse effects of nevirapine were noted in any study mothers or infants. Following maternal dosing with 200 mg during labor, concentrations exceeding 100 ng/mL (10 times the in vitro IC50) were achieved in the newborns. Nevirapine elimination was prolonged in both mothers and infants, with median half-lives ranging from 36.8 to 65.7 h. Administration of 200 mg orally to the mothers in labor and of a single 2-mg/kg oral dose to the infants at 48-72 h after birth maintained serum concentrations in the infants > 100 ng/mL through 7 days of life.
Rights and Permissions
Citation: J Infect Dis. 1998 Aug;178(2):368-74.