This collection showcases the journal articles and other publications authored by faculty and researchers in the Division of Hematology/Oncology in the Department of Pediatrics at the University of Massachusetts Medical School.

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Publications from 2002

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Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line, Zheng Lian, Yuval Kluger, Dov S. Greenbaum, David Tuck, Mark B. Gerstein, Nancy Berliner, Sherman M. Weissman, and Peter E. Newburger

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An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates, Stanley J. Marciniak Jr., Mary A. Mascelli, Mark I. Furman, Alan D. Michelson, Joseph A. Jakubowski, Robert E. Jordan, Peter J. Marchese, and Andrew L. Frelinger III

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Adolescents with cancer: access to clinical trials and age-appropriate care, Peter E. Newburger, Dianne S. Elfenbein, and Laurence A. Boxer

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Platelet-monocyte aggregates in patients with chronic venous insufficiency remain elevated following correction of reflux, Michael J. Rohrer, R. Brannon Claytor, Charles S. C. Garnette, Craig C. Powell, Marc R. Barnard, Mark I. Furman, and Alan D. Michelson

Publications from 2001

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Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation, Kishore R. Alugupalli, Alan D. Michelson, Marc R. Barnard, Douglas Robbins, Jenifer Coburn, Elizabeth K. Baker, Mark H. Ginsberg, Tom G. Schwan, and John M. Leong

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Laser scanning cytometry: a novel method for the detection of platelet--endothelial cell adhesion, R. Brannon Claytor, Jian-ming Li, Mark I. Furman, Charles S. C. Garnette, Michael J. Rohrer, Marc R. Barnard, Lori A. Krueger, Andrew L. Frelinger III, and Alan D. Michelson

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Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G, Elizabeth E. Gardiner, Mariagrazia De Luca, Tracy McNally, Alan D. Michelson, Robert K. Andrews, and Michael C. Berndt

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Genomic and proteomic analysis of the myeloid differentiation program, Zheng Lian, Le Wang, Shigeru Yamaga, Wesley Bonds, Y. Beazer-Barclay, Yuval Kluger, Mark B. Gerstein, Peter E. Newburger, Nancy Berliner, and Sherman M. Weissman

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An unusual intronic mutation in the CYBB gene giving rise to chronic granulomatous disease, D. Noack, Paul G. Heyworth, Peter E. Newburger, and Andrew R. Cross

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Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in the NCF-1 pseudogenes, D. Noack, J. Rae, Andrew R. Cross, Beverly A. Ellis, Peter E. Newburger, John T. Curnutte, and Paul G. Heyworth

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Pediatric oncology in the third world, G. Naheed Usmani

Publications from 2000

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Platelets: New Understanding of Platelet Glycoproteins and Their Role in Disease, James B. Bussel, Thomas J. Kunicki, and Alan D. Michelson

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Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation, Antonio Condino-Neto and Peter E. Newburger

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Antithrombotic therapy in the cardiac catheterization laboratory: focus on antiplatelet agents, Mark I. Furman, Andrew L. Frelinger III, and Alan D. Michelson

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GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood, Mark I. Furman, Lori A. Krueger, Andrew L. Frelinger III, Marc R. Barnard, Mary Ann Mascelli, Marian T. Nakada, and Alan D. Michelson

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The cleaved peptide of PAR1 results in a redistribution of the platelet surface GPIb-IX-V complex to the surface-connected canalicular system, Mark I. Furman, Pauita Nurden, Michael C. Berndt, Alan T. Nurden, Stephen E. Benoit, Marc R. Barnard, Frederick A. Ofosu, and Alan D. Michelson

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Flow cytometric analysis of platelets, Alan D. Michelson

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Evaluation of platelet function by flow cytometry, Alan D. Michelson, Marc R. Barnard, Lori A. Krueger, Andrew L. Frelinger III, and Mark I. Furman

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Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists, Alan D. Michelson, Mark I. Furman, P. Goldschmidt-Clermont, Mary Ann Mascelli, Craig Hendrix, Lindsay Coleman, Jeannette Hamlington, Marc R. Barnard, Thomas Kickler, Douglas J. Christie, Sourav Kundu, and Paul F. Bray

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Global analysis of neutrophil gene expression, Peter E. Newburger, Y. V. B. K. Subrahmanyam, and Sherman M. Weissman

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Recognition and binding of the human selenocysteine insertion sequence by nucleolin, Rui Wu, Qichang Shen, and Peter E. Newburger

Publications from 1999

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Platelet surface p-selectin, platelet-granulocyte heterotypic aggregates, and plasma-soluble p-selectin during plateletpheresis, Marc R. Barnard, Hollace Macgregor, R. Mercier, G. Ragno, L. E. Pivacek, Herbert B. Hechtman, Alan D. Michelson, and C. Robert Valeri

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Fresh, liquid-preserved, and cryopreserved platelets: adhesive surface receptors and membrane procoagulant activity, Marc R. Barnard, Hollace Macgregor, G. Ragno, L. E. Pivacek, Shukri F. Khuri, Alan D. Michelson, and C. Robert Valeri

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Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke, Gili Kenet, Jane Freedman, Boris Shenkman, Eskaraev Regina, Frida Brok-Simoni, Fanny Holzman, Vavva, Nathan Brand, Alan D. Michelson, Maria Trolliet, Joseph Loscalzo, and Aida Inbal

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Comparison of the effects of transfusions of cryopreserved and liquid-preserved platelets on hemostasis and blood loss after cardiopulmonary bypass, Shukri F. Khuri, Nancy Healey, Hollace Macgregor, Marc R. Barnard, Irma O. Szymanski, Vladimir Birjiniuk, Alan D. Michelson, David R. Gagnon, and C. Robert Valeri

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The effects of aspirin and hypothermia on platelet function in vivo, Alan D. Michelson, Marc R. Barnard, Shukri F. Khuri, Michael J. Rohrer, Hollace Macgregor, and C. Robert Valeri

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Laboratory markers of platelet activation and their clinical significance, Alan D. Michelson and Mark I. Furman

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Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets, Alessio Pigazzi, Stanley Heydrick, Franco Folli, Stephen E. Benoit, Alan D. Michelson, and Joseph Loscalzo

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Chronic venous insufficiency is associated with increased platelet and monocyte activation and aggregation, Craig C. Powell, Michael J. Rohrer, Marc R. Barnard, Brian D. Peyton, Mark I. Furman, and Alan D. Michelson

Publications from 1998

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Guidelines for antithrombotic therapy in pediatric patients, Maureen Andrew, Alan D. Michelson, Edwin Bovill, Michael Leaker, and M. Patricia Massicotte

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NADPH oxidase activity and cytochrome b558 content of human Epstein-Barr-virus-transformed B lymphocytes correlate with expression of genes encoding components of the oxidase system, Antonio Condino-Neto and Peter E. Newburger

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Dexamethasone but not indomethacin inhibits human phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity by down-regulating expression of genes encoding oxidase components, Antonio Condino-Neto, Constance Whitney, and Peter E. Newburger

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Differential expression of Id genes in multipotent myeloid progenitor cells: Id-1 is induced by early-and late-acting cytokines while Id-2 is selectively induced by cytokines that drive terminal granulocytic differentiation, Cathleen L. Cooper and Peter E. Newburger

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Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease, Mark I. Furman, Stephen E. Benoit, Marc R. Barnard, C. Robert Valeri, Marie L. Borbone, Richard C. Becker, Herbert B. Hechtman, and Alan D. Michelson

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Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients, J. Himmelfarb, S. Nelson, E. McMonagle, D. Holbrook, Stephen E. Benoit, Alan D. Michelson, and Kenneth Ault

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Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304, Osamu Inanami, Jacqueline L. Johnson, Jeanne K. McAdara, Jamel El Benna, La Rosa P. Faust, Peter E. Newburger, and Bernard M. Babior

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Platelet function in the newborn, Alan D. Michelson

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Antithrombotic therapy in children, Alan D. Michelson, Edwin Bovill, Paul Monagle, and Maureen Andrew

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Patients with venous stasis ulceration have increased monocyte-platelet aggregation, Brian D. Peyton, Michael J. Rohrer, Mark I. Furman, Marc R. Barnard, Louis J. Rodino, Stephen E. Benoit, Herbert B. Hechtman, C. Robert Valeri, and Alan D. Michelson

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X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase, J. Rae, Peter E. Newburger, Mary C. Dinauer, D. Noack, Penelope J. Hopkins, R. Kuruto, and John T. Curnutte

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European Working Group on Clinical Cell Analysis: Consensus protocol for the flow cytometric characterisation of platelet function, Gerd Schmitz, Gregor Rothe, Andreas Ruf, Stefan Barlage, Diethelm Tschope, Kenneth J. Clemetson, Alison H. Goodall, Alan D. Michelson, Alan T. Nurden, and T. Vincent Shankey