Title

Cystic fibrosis heterozygotes do not have increased platelet activation

UMMS Affiliation

Department of Pediatrics

Date

5-2007

Document Type

Article

Medical Subject Headings

Adult; Case-Control Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; *Heterozygote; Humans; Male; Middle Aged; Platelet Activation

Disciplines

Hematology | Oncology | Pediatrics

Abstract

INTRODUCTION: We have previously demonstrated platelet hyperreactivity in cystic fibrosis (CF) patients. Carriers of one CF mutation (heterozygotes) have been shown to have abnormalities related to the presence of only one-half the normal amount of CF transmembrane conductance regulator protein. Platelet hyperreactivity in CF heterozygotes would be an important cardiovascular risk factor, since approximately 1 in 25 Caucasians is a CF carrier.

MATERIALS AND METHODS: We used highly sensitive assays of platelet activation to assess the difference between 16 CF heterozygotes and 16 age- and sex-matched healthy controls without CF mutations.

RESULTS: We found no difference in platelet activation between CF heterozygotes and controls.

CONCLUSIONS: The 50% reduction in the CF transmembrane conductance regulator protein in heterozygotes is insufficient to cause platelet activation.

Rights and Permissions

Citation: Thromb Res. 2007;121(2):159-62. Epub 2007 May 29. doi: 10.1016/j.thromres.2007.04.004

Related Resources

Link to article in PubMed

PubMed ID

17532368