Indices of platelet activation and the stability of coronary artery disease
Authors
Linden, Matthew DeanFurman, Mark I.
Frelinger, Andrew L. III
Fox, Marsha L.
Barnard, Marc R.
Li, YouFu
Przyklenk, Karin
Michelson, Alan D.
UMass Chan Affiliations
Department of AnesthesiologyDepartment of Emergency Medicine
Department of Pediatrics
Document Type
Journal ArticlePublication Date
2007-04-01Keywords
AgedAnti-Inflammatory Agents, Non-Steroidal
Aspirin
CD40 Ligand
Coronary Artery Disease
Epinephrine
Female
Humans
Male
Middle Aged
Neutrophils
P-Selectin
*Platelet Activation
Platelet Function Tests
Platelet Glycoprotein GPIIb-IIIa Complex
Hematology
Oncology
Pediatrics
Metadata
Show full item recordAbstract
AIM: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD). METHODS: Platelet function was examined in 677 consecutive aspirin-treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non-MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups. RESULTS: Compared with non-MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)-100 collagen-epinephrine closure time (CT) and increased circulating monocyte-platelet aggregates, neutrophil-platelet aggregates, activated platelet surface GPIIb-IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non-MI CAD had shortened PFA-100 CTs and increased monocyte-platelet aggregates compared with patients with no CAD. Platelet surface P-selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA-100 CT correlated with the stability of CAD. CONCLUSIONS: Indices of platelet activation, especially the PFA-100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.Source
J Thromb Haemost. 2007 Apr;5(4):761-5. Epub 2007 Feb 26. doi: 10.1111/j.1538-7836.2007.02462.xDOI
10.1111/j.1538-7836.2007.02462.xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/43416PubMed ID
17371489Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1111/j.1538-7836.2007.02462.x