Title

Noncompliance in cardiovascular clinical trials

UMMS Affiliation

Department of Pediatrics

Date

11-2005

Document Type

Article

Medical Subject Headings

Cardiovascular Diseases; Clinical Trials as Topic; Humans; *Treatment Refusal

Disciplines

Hematology | Oncology | Pediatrics

Abstract

This article reviews the current literature on attempts to improve compliance and the effect of NC on clinical trials, with a focus on cardiovascular trials (and antiplatelet therapy in particular). Compliance is a major concern for physicians and researchers not only because of its overwhelming financial impact on health care and its potential to undermine clinical outcomes, but also because it poses critical questions about the validity of results from clinical trials. Understanding the implications of NC in practice and research will serve to improve future clinical trial design to accommodate the confounding aspects associated with NC.

Rights and Permissions

Citation: Am Heart J. 2005 Nov;150(5):882-6. doi: 10.1016/j.ahj.2005.02.039

Related Resources

Link to article in PubMed

PubMed ID

16290953