Platelet function in the newborn
Department of Pediatrics
Medical Subject Headings
Animals; Blood Platelets; Flow Cytometry; Humans; Infant, Newborn; Platelet Function Tests
Hematology | Oncology | Pediatrics
Whole blood flow cytometry, an important new method for the assessment of platelet function, is particularly advantageous for neonatal studies because only minuscule volumes (approximately 2 microL) of blood are required. By this method, we have demonstrated that neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood, as determined by the activation-induced increase in the platelet surface expression of P-selectin and the glycoprotein (GP) IIb-IIIa complex and by the activation-induced decrease in the platelet surface expression of the GPIb-IX complex. Our data suggest that the mechanism of neonatal platelet hyporeactivity is, at least in part, a relative defect in a common signal transduction pathway. We have further demonstrated that the platelets of very low birth weight (VLBW) preterm neonates are maximally hyporeactive on days 3 to 4 of life but return to almost the adult range by days 10 to 14. Given that intraventricular hemorrhage (IVH) is also maximal on days 3 to 4, these defects may contribute to the propensity of VLBW preterm neonates to IVH.
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Citation: Semin Thromb Hemost. 1998;24(6):507-12. doi 10.1055/s-2007-996049