Title

Methods for the measurement of platelet function

UMMS Affiliation

Department of Pediatrics

Date

2-2-2009

Document Type

Article

Medical Subject Headings

Blood Platelets; Hemorrhage; Humans; Platelet Function Tests; Predictive Value of Tests; Thrombosis

Disciplines

Hematology | Oncology | Pediatrics

Abstract

This article discusses the advantages and disadvantages of methods for the measurement of platelet function. The focus is on tests that can be used to monitor antiplatelet activity in the setting of cardiovascular disease and potentially predict thrombosis and bleeding. The tests described are platelet aggregometry; impedance aggregometry; VerifyNow (Accumetrics, San Diego, CA); Plateletworks (Helena Laboratories, Beaumont, TX); platelet surface P-selectin, platelet surface-activated glycoprotein IIb/IIIa, and leukocyte-platelet aggregates; TEG Platelet Mapping system (Haemoscope, Niles, IL); Impact cone and plate(let) analyzer (DiaMed, Cressier, Switzerland); Platelet Function Analyzer-100 (Siemens Healthcare Diagnostics, Inc., Deerfield, IL); phosphorylation of vasodilator-stimulated phosphoprotein; serum thromboxane B(2); and urinary 11-dehydro thromboxane B(2). Some of the factors that differentiate these tests are sample volume requirements, the use of whole blood, the presence of shear, point-of-care status, need for a technician, and expense.

Rights and Permissions

Citation: Am J Cardiol. 2009 Feb 2;103(3 Suppl):20A-26A. doi 10.1016/j.amjcard.2008.11.019

Related Resources

Link to article in PubMed

PubMed ID

19166709