Title
Methods for the measurement of platelet function
UMMS Affiliation
Department of Pediatrics
Date
2-2-2009
Document Type
Article
Medical Subject Headings
Blood Platelets; Hemorrhage; Humans; Platelet Function Tests; Predictive Value of Tests; Thrombosis
Disciplines
Hematology | Oncology | Pediatrics
Abstract
This article discusses the advantages and disadvantages of methods for the measurement of platelet function. The focus is on tests that can be used to monitor antiplatelet activity in the setting of cardiovascular disease and potentially predict thrombosis and bleeding. The tests described are platelet aggregometry; impedance aggregometry; VerifyNow (Accumetrics, San Diego, CA); Plateletworks (Helena Laboratories, Beaumont, TX); platelet surface P-selectin, platelet surface-activated glycoprotein IIb/IIIa, and leukocyte-platelet aggregates; TEG Platelet Mapping system (Haemoscope, Niles, IL); Impact cone and plate(let) analyzer (DiaMed, Cressier, Switzerland); Platelet Function Analyzer-100 (Siemens Healthcare Diagnostics, Inc., Deerfield, IL); phosphorylation of vasodilator-stimulated phosphoprotein; serum thromboxane B(2); and urinary 11-dehydro thromboxane B(2). Some of the factors that differentiate these tests are sample volume requirements, the use of whole blood, the presence of shear, point-of-care status, need for a technician, and expense.
Rights and Permissions
Citation: Am J Cardiol. 2009 Feb 2;103(3 Suppl):20A-26A. doi 10.1016/j.amjcard.2008.11.019