Investigating the mechanisms of hyporesponse to antiplatelet approaches
Department of Pediatrics
Medical Subject Headings
Aspirin; Blood Platelets; *Drug Resistance; Drug Therapy, Combination; Genetic Predisposition to Disease; Humans; Patient Selection; Platelet Aggregation Inhibitors; *Platelet Function Tests; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome
Hematology | Oncology | Pediatrics
Hyporesponsiveness, or resistance, to antiplatelet therapy may be a major contributor to poorer outcomes among cardiac patients and may be attributed to an array of mechanisms--both modifiable and unmodifiable. Recent evidence has uncovered clinical, cellular, and genetic factors associated with hyporesponsiveness. Patients with severe acute coronary syndromes (ACS), type 2 diabetes, and increased body mass index appear to be the most at risk for hyporesponsiveness. Addressing modifiable mechanisms may offset hyporesponsiveness, while recognizing unmodifiable mechanisms, such as genetic polymorphisms and diseases that affect response to antiplatelet therapy, may help identify patients who are more likely to be hyporesponsive. Hyporesponsive patients might benefit from different dosing strategies or additional antiplatelet therapies. Trials correlating platelet function test results to clinical outcomes are required. Results from these studies could cause a paradigm shift toward individualized antiplatelet therapy, improving predictability of platelet inhibition, and diminishing the likelihood for hyporesponsiveness.
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Citation: Clin Cardiol. 2008 Mar;31(3 Suppl 1):I21-7. doi 10.1002/clc.20360