The problem of persistent platelet activation in acute coronary syndromes and following percutaneous coronary intervention
Authors
Braunwald, EugeneAngiolillo, Dominick J.
Bates, Eric
Berger, Peter B.
Bhatt, Deepak
Cannon, Christopher P.
Furman, Mark I.
Gurbel, Paul A.
Michelson, Alan D
Peterson, Eric D.
Wiviott, Stephen D.
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2008-03-01Keywords
Acute Coronary SyndromeAngioplasty, Balloon, Coronary
Aspirin
Humans
Platelet Activation
Platelet Aggregation Inhibitors
Platelet Glycoprotein GPIIb-IIIa Complex
Pyridines
Thrombosis
Hematology
Oncology
Pediatrics
Metadata
Show full item recordAbstract
Platelets play a central role in the atherosclerotic inflammatory response, thrombotic vascular occlusion, microembolization, vasoconstriction, and plaque progression. Persistent platelet activation poses a serious problem among patients with acute coronary syndromes (ACS) and those who have undergone percutaneous coronary intervention (PCI), placing them at risk for ischemic events and subacute stent thrombosis. Patients undergoing PCI are at risk for further ischemic events because of procedure-related platelet activation as well as the inherent persistent platelet hyperreactivity and enhanced thrombin generation associated with ACS. Persistent platelet activation following an acute coronary event and/or PCI supports incorporating antiplatelet strategies into the standard medical management of such patients. In this clinical setting, antiplatelet therapies are capable of improving outcomes. Aspirin, thienopyridines, and glycoprotein IIb/IIIa inhibitors, the 3 major pharmacologic approaches to persistent platelet activation, target various levels of the hemostatic pathways and thrombus formation.Source
Clin Cardiol. 2008 Mar;31(3 Suppl 1):I17-20. doi 10.1002/clc.20363DOI
10.1002/clc.20363Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43302PubMed ID
18481817Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/clc.20363