UMMS Affiliation

Department of Pediatrics; Department of Quantitative Health Sciences; Senior Scholars Program

Date

12-4-2014

Document Type

Article

Disciplines

Digestive System Diseases | Endocrinology, Diabetes, and Metabolism | Gastroenterology | Pediatrics

Abstract

Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.

Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.

Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (� = 22, 9.9 ± 3.1 y), CD only (� = 18, 8.9 ± 3.3 y), or T1D only (� = 22, 10.1 ± 2.8 y) were compared to 49 controls of the age of 8.0 ± 2.6 years. Vitamin D deficiency was defined as 25(OH)D < 50 nmol/L, overweight as BMI of > 85th but < 95th percentile, and obesity as BMI > 95th percentile.

Results. The 4 groups had no difference in 25(OH)D (ANOVA � = 0.123) before stratification into normal-weight versus overweight/obese subtypes. Following stratification, 25(OH)D differed significantly between the subgroups (�(3,98) = 10.109, ANOVA � < 0.001). Post-hoc analysis showed a significantly lower 25(OH)D in the overweight/obese CD + T1D compared to the overweight/obese controls () and the overweight/obese CD (� = 0.039) and the overweight/obese CD (� = 0.003). Subjects with CD + T1D were 3 times more likely to be vitamin D deficient (OR = 3.1 [0.8–11.9], � = 0.098), compared to controls.

Conclusions. The coexistence of T1D and CD in overweight/obese prepubertal children may be associated with lower vitamin D concentration.

Comments

Citation: Setty-Shah N, Maranda L, Nwosu BU. Increased risk for vitamin d deficiency in obese children with both celiac disease and type 1 diabetes. Gastroenterol Res Pract. 2014;2014:561351. doi: 10.1155/2014/561351. Epub 2014 Dec 4. PubMed PMID:25548555; PubMed Central PMCID: PMC4273505. Link to article on publisher's site

Nithya Setty-Shah participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources

Link to article in PubMed

Keywords

Vitamin D, obesity, celiac disease, Type 1 diabetes, child

PubMed ID

25548555

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

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