Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children
Authors
Setty-Shah, NithyaMaranda, Louise S.
Candela, Ninfa
Fong, Jay G.
Dahod, Idris
Rogol, Alan D.
Nwosu, Benjamin U.
UMass Chan Affiliations
Senior Scholars ProgramDepartment of Quantitative Health Sciences
Department of Pediatrics
Document Type
Journal ArticlePublication Date
2013-10-25Keywords
Vitamin D deficiencyLactose intolerance
Children
Obesity
Hydrogen
Body Mass Index
Short stature
Endocrinology, Diabetes, and Metabolism
Pediatrics
Metadata
Show full item recordAbstract
Background: The health consequences of lactose intolerance (LI) are unclear. Aims: To investigate the effects of LI on stature and vitamin D status. Hypotheses: LI subjects will have similar heights and vitamin D status as controls. Subjects and Methods: Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume Results: There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into normal weight (BMI percentile) vs. overweight/obese (BMI ≥85th percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, p = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, p = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, p = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, p = 0.28). MPTH z-score was similar between the groups. Conclusion: Short stature and vitamin D deficiency are not features of LI in prepubertal children.Source
Setty-Shah N, Maranda L, Candela N, Fong J, Dahod I, Rogol AD, Nwosu BU. Lactose intolerance: lack of evidence for short stature or vitamin D deficiency in prepubertal children. PLoS One. 2013 Oct 25;8(10):e78653. doi:10.1371/journal.pone.0078653. eCollection 2013. PubMed PMID: 24205288; PubMed Central PMCID: PMC3808302. Link to article on publisher's site
DOI
10.1371/journal.pone.0078653Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43219PubMed ID
24205288Notes
Supporting information is available under Additional Files below, and also at http://escholarship.umassmed.edu/datasets/1/.
Nithya Setty-Shah participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.
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Copyright: 2013 Setty-Shah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.