UMMS Affiliation

Department of Pediatrics



Document Type


Medical Subject Headings

Vitamin D; Asthma


Endocrinology, Diabetes, and Metabolism | Pediatrics | Respiratory Tract Diseases


Background: There is no consensus on the association between vitamin D and asthma.

Objective: To determine the relationship between 25-hydroxyvitamin D [25(OH)D] levels and asthma symptom severity in children and adolescents.

Methods: A retrospective, case-control study of 263 subjects of ages 2–19 years with asthma who were compared to 284 non-asthmatic controls of similar ages. Subjects were excluded if they had diseases of calcium or vitamin D metabolism or were receiving calcium or vitamin D supplementation. Serum 25(OH)D was measured in all subjects. Asthma symptom severity, usually stratified into 6 steps, was stratified into five steps [1–5] based on the number and dose of controller medications used as outlined by the National Heart, Lung, and Blood Institute’s guidelines. Mean 25(OH)D values were compared between the asthmatic patients and controls, as well as among the five steps of asthma symptom severity. Results were adjusted for age, sex, BMI, race and severity of asthma symptoms.

Results:There was no difference in 25(OH)D between asthmatic patients and controls (28.64±10.09 vs. 28.42±11.47, p=1.0). However, there was a significant difference in 25(OH)D between obese and non-obese asthmatic patients (23.33±7.67 vs. 30.16±10.20, p

Conclusions: There were no differences in mean 25(OH)D levels between asthmatic patients and controls. Mean 25(OH)D level was significantly lower in both the obese asthmatic patients and obese controls. Asthma severity had no relationship to mean 25(OH)D levels.


Publisher PDF posted as allowed by the publisher's author rights policy at The final publication is available at

Citation: Journal of Pediatric Endocrinology and Metabolism 2012;25(7-8):673-9. DOI 10.1515/jpem-2012-0143. Link to article on publisher's website

Medical student Jennifer Menon participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources

Link to article in PubMed



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