Rapid-response extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in children with cardiac disease
Authors
Kane, David A.Thiagarajan, Ravi R.
Wypij, David
Scheurer, Mark A.
Fynn-Thompson, Francis
Emani, Sitaram
del Nido, Pedro J.
Betit, Peter
Laussen, Peter C.
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2010-09-14Keywords
Boston*Cardiopulmonary Resuscitation
*Databases, Factual
Disease-Free Survival
*Extracorporeal Membrane Oxygenation
Female
Heart Diseases
Humans
Infant
Male
Retrospective Studies
Risk Factors
Survival Rate
Time Factors
Cardiology
Pediatrics
Metadata
Show full item recordAbstract
BACKGROUND: Survival of children with in-hospital cardiac arrest that does not respond to conventional cardiopulmonary resuscitation (CPR) is poor. We report on survival and early neurological outcomes of children with heart disease supported with rapid-response extracorporeal membrane oxygenation (ECMO) to aid cardiopulmonary resuscitation (ECPR). METHODS AND RESULTS: Children with heart disease supported with ECPR were identified from our ECMO database. Demographic, CPR, and ECMO details associated with mortality were evaluated using multivariable logistic regression. Pediatric overall performance category and pediatric cerebral performance category scores were assigned to ECPR survivors to assess neurological outcomes. There were 180 ECPR runs in 172 patients. Eighty-eight patients (51%) survived to discharge. Survival in patients who underwent ECPR after cardiac surgery (54%) did not differ from nonsurgical patients (46%). Survival did not vary by cardiac diagnosis and CPR duration did not differ between survivors and nonsurvivors. Factors associated with mortality included noncardiac structural or chromosomal abnormalities (OR, 3.2; 95% CI, 1.3-7.9), use of blood-primed ECMO circuit (OR, 7.1; 95% CI, 1.4-36), and arterial pH <7.00 after ECMO deployment (OR, 6.0; 95% CI, 2.1-17.4). Development of end-organ injury on ECMO and longer ECMO duration were associated with increased mortality. Of pediatric overall performance category/pediatric cerebral performance category scores assigned to survivors, 75% had scores less than or equal to 2, indicating no to mild neurological injury. CONCLUSIONS: ECPR may promote survival in children with cardiac disease experiencing cardiac arrest unresponsive to conventional CPR with favorable early neurological outcomes. CPR duration was not associated with mortality, whereas patients with metabolic acidosis and noncardiac structural or chromosomal anomalies had higher mortality.Source
Circulation. 2010 Sep 14;122(11 Suppl):S241-8. Link to article on publisher's siteDOI
10.1161/CIRCULATIONAHA.109.928390Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43139PubMed ID
20837920Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1161/CIRCULATIONAHA.109.928390