Intrapancreatic schwannoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology
Department of Pathology
Medical Subject Headings
Adult; Biopsy, Fine-Needle; Collagen Type IV; Endoscopy; Humans; Male; Neurilemmoma; Pancreatic Neoplasms; Proto-Oncogene Proteins c-kit; S100 Proteins
Schwannoma is a tumor of neuro-ectodermal origin, usually occuring in the head and neck and extremities. A retroperitoneal, and particularly intra-pancreatic presentation is very rare, and poses a clinical and diagnostic challenge. We report a case of a male patient who underwent an Endoscopic Ultrasound-guided Fine Needle Aspiration (EUS-FNA) biopsy of a hypoechoic, intra-pancreatic mass. The onsite cytological evaluation was consistent with a spindle cell neoplasm. Further evaluation, aided by immunohistochemical stains, defined the mass as a Schwannoma. The patient then underwent a pancreaticoduodenectomy and the histopathological diagnosis of the surgical specimen confirmed the cytological diagnosis. To our knowledge, this is the first report of intra-pancreatic Schwannoma diagnosed preoperatively by EUS-FNA cytology.
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Citation: Diagn Cytopathol. 2009 Feb;37(2):132-5. Link to article on publisher's site