The Department of Pathology at the University of Massachusetts Medical School is committed to excellence in the three areas that comprise its mission:

* The practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates.

* The advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice.

* The training of medical and graduate students, clinical and research fellows, and pathology residents.

This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.

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Publications from 2014

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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype, Ryan W. Serra, Minggang Fang, Sung Mi Park, Lloyd Hutchinson, and Michael R. Green

Publications from 2013

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Acute kidney injury due to intravenous bleach injection, Verma Ashish, Vijay Vanguri, Venkata Golla, Sean Hyun Rhyee, Matthew Trainor, and Abramov Konstantin

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Novel FGFR3 rearrangement t(4;22)(p16;q11.2) in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma, Jan Cerny, Hongbo Yu, and Patricia M. Miron

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Detection of necrosis by release of lactate dehydrogenase activity, Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa

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Pilomatrix carcinoma: a case report and review of the literature, Kristine M. Cornejo and April Deng

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Malignant melanoma within squamous cell carcinoma and basal cell carcinoma: is it a combined or collision tumor?--a case report and review of the literature, Kristine M. Cornejo and April C. Deng

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A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression, Kristine M. Cornejo, Christopher A. Lum, and Allan K. Izumi

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Pulmonary papillary adenoma: a case report and review of the literature, Kristine M. Cornejo, Min Shi, Ali Akalin, Karl Uy, Philip T. Cagle, and Armando E. Fraire

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Performance differences between conventional smears and liquid-based preparations of thyroid fine-needle aspiration samples: analysis of 47,076 responses in the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytology, Andrew H. Fischer, Amy C. Clayton, Joel S. Bentz, Patricia G. Wasserman, Michael R. Henry, Rhona J. Souers, and Ann T. Moriarty

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HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism, Abigail I. Guce, Sarah E. Mortimer, Taejin Yoon, Corrie A. Painter, Wei Jiang, Elizabeth D. Mellins, and Lawrence J. Stern

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IL-1 Generated Subsequent to Radiation-induced Tissue Injury Contributes to the Pathogenesis of Radiodermatitis, Matthew Janko, Fernando Ontiveros, Thomas J. Fitzgerald, April Deng, Maria DeCicco, and Kenneth L. Rock

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Renal biopsy: comparative yield of cranial versus caudal needle trajectory. An ex vivo analysis, Adib R. Karam, Gopal Vijayaraghavan, Ashraf Khan, Berrin Ustun, and Sarwat Hussain

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SMAD regulatory networks construct a balanced immune system, Nidhi Malhotra and Joonsoo Kang

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A network of high-mobility group box transcription factors programs innate interleukin-17 production, Nidhi Malhotra, Kavitha Narayan, Ok Hyun Cho, Katelyn E. Sylvia, Catherine C. Yin, Heather J. Melichar, Medhi Rashighi, Veronique Lefebvre, John E. Harris, Leslie J. Berg, and Joonsoo Kang

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CYLD deubiquitinates RIP1 in the TNFalpha-induced necrosome to facilitate kinase activation and programmed necrosis, David M. Moquin, Thomas McQuade, and Francis Ka-Ming Chan

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Effects of Transitioning From Conventional Methods to Liquid Based Methods on Unsatisfactory Pap Tests: Results from a Multicenter U.S. Study (poster), Christopher L. Owens, Daniel J. Peterson, Aruna Kamineni, Diana S. M. Buist, Sheila Weinmann, Tyler R. Ross, Andrew E. Williams, Azadeh Stark, Kenneth F. Adams, and Terry S. Field

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AIRP best cases in radiologic-pathologic correlation: lactating adenoma, Allyson N. Parnes, Ali Akalin, Robert M. Quinlan, and Gopal R. Vijayaraghavan

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Uric acid as a danger signal in gout and its comorbidities, Kenneth L. Rock, Hiroshi Kataoka, and Jiann-Jyh Lai

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Improved detection rate of cytogenetic abnormalities in chronic lymphocytic leukemia and other mature B-cell neoplasms with use of CpG-oligonucleotide DSP30 and interleukin 2 stimulation, Min Shi, Matthew J. Cipollini, Patricia Crowley-Bish, Anne W. Higgins, Hongbo Yu, and Patricia M. Miron

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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Generalized Spinous Follicular Lichen Nitidus with Perifollicular Granulomas, Heather S. Summe, Sheila M. Greenlaw, April Deng, Cynthia Magro, and Karen Wiss

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The N-terminus of vaccinia virus host range protein C7L is essential for function, Masanori Terajima, Stina L. Urban, and Anita M. Leporati

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Advances in understanding the pathogenesis of HLH, G. Naheed Usmani, Bruce A. Woda, and Peter E. Newburger

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Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection, Vijay Vanguri, Christopher Govern, Rebecca Smith, and Eric Huseby

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NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections, Raymond M. Welsh and Stephen N. Waggoner

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Anti-IFN-gamma and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cells, Myriam F. Wlodarczyk, Anke R. Kraft, Hong D. Chen, Laurie L. Kenney, and Liisa K. Selin

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The Tec kinase ITK regulates thymic expansion, emigration, and maturation of gammadelta NKT cells, Catherine C. Yin, Ok Hyun Cho, Katelyn E. Sylvia, Kavitha Narayan, Amanda L. Prince, John W. Evans, Joonsoo Kang, and Leslie J. Berg

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CD4+ T Cells Provide Intermolecular Help To Generate Robust Antibody Responses in Vaccinia Virus-Vaccinated Humans, Liusong Yin, J. Mauricio Calvo-Calle, John Cruz Jr., Frances K. Newman, Sharon E. Frey, Francis A. Ennis, and Lawrence J. Stern

Publications from 2012

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ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice, Hugh S. Gannon, Bruce A. Woda, and Stephen N. Jones

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Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer

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A novel murine infection model for Shiga toxin-producing Escherichia coli, Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, and David B. Schauer

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Human CD4+ T cell response to human herpesvirus 6, Maria-Dorothea Nastke, Aniuska Becerra, Liusong Yin, Omar Dominguez-Amorocho, Laura L. Gibson, Lawrence J. Stern, and J. Mauricio Calvo-Calle

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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Diagnostic Patterns and Immunohistochemical Stain Usage in Extended Core Prostate Biopsies: Comparisons Between Genitourinary and Non-Genitourinary Pathologists, Anna Plourde, Zhong Jiang, and Christopher L. Owens

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

Publications from 2011

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IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer, Di Lu, Xiaofang Yang, Naomi Y. Jiang, Bruce A. Woda, Qin Liu, Karen A. Dresser, Arthur M. Mercurio, Kenneth L. Rock, and Zhong Jiang

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Metastatic squamous cell carcinoma of the vulva mimicking primary varicella-zoster virus infection, Jeffrey D. Mailhot, Patrick O'Donnell, Rujing Han, Susan L. Zweizig, and David E. Geist

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Effect of Paget's disease on survival in breast cancer: an exploratory study, Sonia Ortiz-Pagan, Gina Cunto-Amesty, Sandeep Narayan, Sybil L. Crawford, Chase Derrick, Anne C. Larkin, Ashraf Khan, Robert M. Quinlan, and Rakhshanda Layeequr Rahman

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Conformational lability in the class II MHC 3-10 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange, Corrie A. Painter, Maria P. Negroni, Kathy A. Kellersberger, Zarixia Zavala-Ruiz, James E. Evans, and Lawrence J. Stern

Publications from 2010

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Heritability of apnea of prematurity: a retrospective twin study, Elisabeth Bloch-Salisbury, Mei Hua Hall, Priya Sharma, Theonia Boyd, Francis J. Bednarek, and David Paydarfar

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

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p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer

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Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock

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A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49, Guozheng Liu, Shuping Dou, Stephen P. Baker, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

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Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

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TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales

Publications from 2009

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Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report, Oguz Cataltepe, Paul C. Marshall, and Thomas W. Smith

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The hair follicle barrier to involvement by malignant melanoma, Olga Pozdnyakova, Joseph Grossman, Belinda Barbagallo, and Stephen Lyle

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Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis, Jyoti P. Ramakrishna, Amy R. Johnson, and Barbara F. Banner

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Pathobiology of inflammation to cell death, Kenneth L. Rock

Publications from 2008

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CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock

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Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia, Jessica C. Hochberg, Patricia M. Miron, Beverly N. Hay, Bruce A. Woda, Sa A. Wang, Monika Richert-Przygonska, Andrew A.G. Aprikyan, and Peter E. Newburger

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Veit Hornung, Franz G. Bauernfeind, Annett Halle, Eivind O. Samstad, Hajime Kono, Kenneth L. Rock, Katherine A. Fitzgerald, and Eicke Latz

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Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas, Zhong Jiang, Christine M. Lohse, Peigou G. Chu, Chin-Lee Wu, Bruce A. Woda, Kenneth L. Rock, and Eugene D. Kwon

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IMP3 predicts aggressive superficial urothelial carcinoma of the bladder, Lioudmila Sitnikova, Gary Wayne Mendese, Qin Liu, Bruce A. Woda, Di Lu, Karen A. Dresser, Sambit Mohanty, Kenneth L. Rock, and Zhong Jiang

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Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections, Charles Fenton Towne, Ian A. York, Joost J. Neijssen, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Jacques J. Neefjes, and Kenneth L. Rock

Publications from 2007

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CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock

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Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses, Charles Fenton Towne, Ian A. York, Levi B. Watkin, John S. Lazo, and Kenneth L. Rock

Publications from 2006

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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals, Chun-Jen Chen, Yan Shi, Arron Hearn, Katherine A. Fitzgerald, Douglas T. Golenbock, George W. Reed, Shizuo Akira, and Kenneth L. Rock

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IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression, Cuizhen Li, Kenneth L. Rock, Bruce A. Woda, Zhong Jiang, Armando E. Fraire, and Karen A. Dresser

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Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model, Yan Shi, Shelly A. Galusha, and Kenneth L. Rock

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The ultrastructure of MCF-10A acini, Jean. M. Underwood, Karen M. Imbalzano, Valerie M. Weaver, Andrew H. Fischer, Anthony N. Imbalzano, and Jeffrey A. Nickerson

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Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation, Ian A. York, Nidhi Bhutani, Sophia Zendzian, Alfred L. Goldberg, and Kenneth L. Rock

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Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance, Ian A. York, Michael A. Brehm, Sophia Zendzian, Charles Fenton Towne, and Kenneth L. Rock

Publications from 2005

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Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells, Lu-Ann M. Pozzi, Joseph Walter Maciaszek, and Kenneth L. Rock

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Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation, Charles Fenton Towne, Ian A. York, Joost J. Neijssen, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Jacques J. Neefjes, and Kenneth L. Rock

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A mutant cell with a novel defect in MHC class I quality control, Ian A. York, Ethan P. Grant, A. Maria Dahl, and Kenneth L. Rock

Publications from 2004

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Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas, Armando Ciampa, Gary R. Fanger, Ashraf Khan, Kenneth L. Rock, and Bo Xu

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Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, and Anthony N. Imbalzano

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Cellular protein is the source of cross-priming antigen in vivo, Lianjun Shen and Kenneth L. Rock

Publications from 2003

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The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation, Ian A. York, Annie X. Y. Mo, Kristen Lemerise, Wanyong Zeng, Yuelei Shen, Carmela R. Abraham, Tomo Saric, Alfred L. Goldberg, and Kenneth L. Rock

Publications from 2001

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones

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Anti-peptide antibody blocks peptide binding to MHC class I molecules in the endoplasmic reticulum, Craig J. Hilton, A. Maria Dahl, and Kenneth L. Rock

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Absence of hippocampal sclerosis in children with multiple daily seizures since infancy, Sanjeev V. Kothare, Ana Sotrel, Michael Duchowny, Prasanna Jayakar, Paul C. Marshall, and Thomas W. Smith

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Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides, Annie X. Y. Mo, Steven F. L. van Lelyveld, Abie Craiu, and Kenneth L. Rock

Publications from 2000

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Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations, Christine Margaret Boyle and Harriet L. Robinson

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Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses, Yan Shi, Wanyong Zeng, and Kenneth L. Rock

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Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation, Luis J. Sigal and Kenneth L. Rock

Publications from 1999

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A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis, Dancella M. Fernandes, Allison Michelle Baird, Leslie J. Berg, and Kenneth L. Rock

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Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides, Annie X. Y. Mo, Paolo Cascio, Kristen Lemerise, Alfred L. Goldberg, and Kenneth L. Rock

Publications from 1998

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The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo, Luis J. Sigal, Hans Reiser, and Kenneth L. Rock

Publications from 1992

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Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker, John J. Nunnari, Marc Fisher, and Stanley D. T. White