* The practice of anatomic and clinical pathology diagnosis and consultation for a large academic medical center and its community affiliates.
* The advancement of knowledge through basic and clinical research and the translation of advances from the laboratory to clinical practice.
* The training of medical and graduate students, clinical and research fellows, and pathology residents.
This collection showcases the the journal articles, books, book chapters, and other publications and presentations written by faculty and researchers of the Department of Pathology.
Publications from 2013
A review of reporting systems and terminology for urine cytology, Christopher L. Owens, Christopher J. Vandenbussche, Frances H. Burroughs, and Dorothy L. Rosenthal
The Johns Hopkins Hospital template for urologic cytology samples : Part I-Creating the template, Dorothy L. Rosenthal, Christopher J. Vandenbussche, Frances H. Burroughs, Srividya Sathiyamoorthy, Hui Guan, and Christopher L. Owens
The Johns Hopkins Hospital template for urologic cytology samples : Parts II and III-Improving the predictability of indeterminate results in urinary cytologic samples: an outcomes and cytomorphologic study, Christopher J. Vandenbussche, Srividya Sathiyamoorthy, Christopher L. Owens, Frances H. Burroughs, Dorothy L. Rosenthal, and Hui Guan
Publications from 2012
ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice, Hugh S. Gannon, Bruce A. Woda, and Stephen N. Jones
Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer
A novel murine infection model for Shiga toxin-producing Escherichia coli, Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, and David B. Schauer
Human CD4+ T cell response to human herpesvirus 6, Maria-Dorothea Nastke, Aniuska Becerra, Liusong Yin, Omar Dominguez-Amorocho, Laura L. Gibson, Lawrence J. Stern, and J. Mauricio Calvo-Calle
Diagnostic Patterns and Immunohistochemical Stain Usage in Extended Core Prostate Biopsies: Comparisons Between Genitourinary and Non-Genitourinary Pathologists, Anna Plourde, Zhong Jiang, and Christopher L. Owens
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang
Fine needle aspiration of intrapancreatic accessory spleen: Cytomorphologic features and differential diagnosis, Armanda D. Tatsas, Christopher L. Owens, Momin T. Siddiqui, Ralph H. Hruban, and Syed Z. Ali
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li
Publications from 2011
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer, Di Lu, Xiaofang Yang, Naomi Y. Jiang, Bruce A. Woda, Qin Liu, Karen A. Dresser, Arthur M. Mercurio, Kenneth L. Rock, and Zhong Jiang
Improved preoperative definitive diagnosis of papillary thyroid carcinoma in FNAs prepared with both ThinPrep and conventional smears compared with FNAs prepared with ThinPrep alone, Martin H. Luu, Andrew H. Fischer, Latha Pisharodi, and Christopher L. Owens
Atypical follicular cells with equivocal features of papillary thyroid carcinoma is not a low-risk cytologic diagnosis, Martin H. Luu, Andrew H. Fischer, Thomas J. Stockl, Latha Pisharodi, and Christopher L. Owens
Metastatic squamous cell carcinoma of the vulva mimicking primary varicella-zoster virus infection, Jeffrey D. Mailhot, Patrick O'Donnell, Rujing Han, Susan L. Zweizig, and David E. Geist
Effect of Paget's disease on survival in breast cancer: an exploratory study, Sonia Ortiz-Pagan, Gina Cunto-Amesty, Sandeep Narayan, Sybil L. Crawford, Chase Derrick, Anne C. Larkin, Ashraf Khan, Robert M. Quinlan, and Rakhshanda Layeequr Rahman
Combined carcinoid tumor and squamous cell carcinoma of lung: expanding the spectrum of combined tumors of lung, Christopher L. Owens and Armando E. Fraire
Conformational lability in the class II MHC 3-10 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange, Corrie A. Painter, Maria P. Negroni, Kathy A. Kellersberger, Zarixia Zavala-Ruiz, James E. Evans, and Lawrence J. Stern
Publications from 2010
Thyroid bed fine-needle aspiration: experience at a large tertiary care center, Justin A. Bishop, Christopher L. Owens, Chung H. Shum, and Syed Z. Ali
Heritability of apnea of prematurity: a retrospective twin study, Elisabeth Bloch-Salisbury, Mei Hua Hall, Priya Sharma, Theonia Boyd, Francis J. Bednarek, and David Paydarfar
Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin
CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz
p53 represses class switch recombination to IgG2a through its antioxidant function, Jeroen E. J. Guikema, Carol E. Schrader, Michael H. Brodsky, Erin K. Linehan, Adam Richards, Nahla El Falaky, Daniel H. LI, Hayla Karen Sluss, Eva Szomolanyi-Tsuda, and Janet Stavnezer
Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock
A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49, Guozheng Liu, Shuping Dou, Stephen P. Baker, Ali Akalin, Dengfeng Cheng, Ling Chen, Mary Rusckowski, and Donald J. Hnatowich
Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment, Kavitha Narayan and Joonso Kang
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses, Vijay A.K. Rathinam, Zhaozhao Jiang, Stephen N. Waggoner, Shrutie Sharma, Leah E. Cole, Lisa Waggoner, Sivapriya Kailasan Vanaja, Brian G. Monks, Sandhya Ganesan, Eicke Latz, Veit Hornung, Stefanie N. Vogel, Eva Szomolanyi-Tsuda, and Katherine A. Fitzgerald
Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern
TLR4 is a negative regulator in noninfectious lung inflammation, Hang Zhao, Shaw-Wei Leu, Liyun Shi, Rejmon Dedaj, Gaofeng Zhao, Hari G. Garg, Lianjun Shen, Egil Lien, Katherine A. Fitzgerald, Aviva Shiedlin, Huahao Shen, Deborah A. Quinn, and Charles A. Hales
Publications from 2009
Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report, Oguz Cataltepe, Paul C. Marshall, and Thomas W. Smith
Analysis of ThinPrep cytology in establishing the diagnosis of small cell carcinoma of lung, Stacey Kim and Christopher L. Owens
Intrapancreatic schwannoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology, Shaoying Li, Syed Z. Ali, Christopher L. Owens, and Peter Kulesza
The hair follicle barrier to involvement by malignant melanoma, Olga Pozdnyakova, Joseph Grossman, Belinda Barbagallo, and Stephen Lyle
Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis, Jyoti P. Ramakrishna, Amy R. Johnson, and Barbara F. Banner
Pathobiology of inflammation to cell death, Kenneth L. Rock
Publications from 2008
CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock
Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia, Jessica C. Hochberg, Patricia M. Miron, Beverly N. Hay, Bruce A. Woda, Sa A. Wang, Monika Richert-Przygonska, Andrew A.G. Aprikyan, and Peter E. Newburger
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Veit Hornung, Franz G. Bauernfeind, Annett Halle, Eivind O. Samstad, Hajime Kono, Kenneth L. Rock, Katherine A. Fitzgerald, and Eicke Latz
Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas, Zhong Jiang, Christine M. Lohse, Peigou G. Chu, Chin-Lee Wu, Bruce A. Woda, Kenneth L. Rock, and Eugene D. Kwon
An atypical case of fatal zygomycosis: simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor, Kristine E. Johnson, Kevin Leahy, Christopher L. Owens, Joel N. Blankson, William G. Merz, and Bradley J. Goldstein
Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions, Christopher L. Owens, Natasha Rekhtman, Lori Sokoll, and Syed Z. Ali
IMP3 predicts aggressive superficial urothelial carcinoma of the bladder, Lioudmila Sitnikova, Gary Wayne Mendese, Qin Liu, Bruce A. Woda, Di Lu, Karen A. Dresser, Sambit Mohanty, Kenneth L. Rock, and Zhong Jiang
Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections, Charles Fenton Towne, Ian A. York, Joost J. Neijssen, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Jacques J. Neefjes, and Kenneth L. Rock
Publications from 2007
CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help, Maria Genevieve H. Hernandez, Lianjun Shen, and Kenneth L. Rock
Mucinous tubular and spindle cell carcinoma of the kidney: cytopathologic findings, Christopher L. Owens, Pedram Argani, and Syed Z. Ali
Significance of denuded urothelium in papillary urothelial lesions, Christopher L. Owens and Jonathan I. Epstein
Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistry, Christopher L. Owens, Jonathan I. Epstein, and George J. Netto
"Low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion" is a distinct cytologic category: histologic outcomes and HPV prevalence, Christopher L. Owens, Diana R. Moats, Frances H. Burroughs, and Karen S. Gustafson
Deep fibromatosis (desmoid tumor): cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine-needle aspiration, Christopher L. Owens, Rajni Sharma, and Syed Z. Ali
Cytopathologic findings in "POEMS" syndrome associated with Castleman disease, Christopher L. Owens, Edward G. Weir, and Syed Z. Ali
Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses, Charles Fenton Towne, Ian A. York, Levi B. Watkin, John S. Lazo, and Kenneth L. Rock
Publications from 2006
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals, Chun-Jen Chen, Yan Shi, Arron Hearn, Katherine A. Fitzgerald, Douglas T. Golenbock, George W. Reed, Shizuo Akira, and Kenneth L. Rock
IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression, Cuizhen Li, Kenneth L. Rock, Bruce A. Woda, Zhong Jiang, Armando E. Fraire, and Karen A. Dresser
Histologic and electron microscopy findings in myocardium of treated Fabry disease, Christopher L. Owens, Stuart D. Russell, and Marc K. Halushka
Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model, Yan Shi, Shelly A. Galusha, and Kenneth L. Rock
The ultrastructure of MCF-10A acini, Jean. M. Underwood, Karen M. Imbalzano, Valerie M. Weaver, Andrew H. Fischer, Anthony N. Imbalzano, and Jeffrey A. Nickerson
Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation, Ian A. York, Nidhi Bhutani, Sophia Zendzian, Alfred L. Goldberg, and Kenneth L. Rock
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance, Ian A. York, Michael A. Brehm, Sophia Zendzian, Charles Fenton Towne, and Kenneth L. Rock
Publications from 2005
Atypical squamous cells in exfoliative urinary cytology: clinicopathologic correlates, Christopher L. Owens and Syed Z. Ali
Metastatic breast carcinoma involving the thyroid gland diagnosed by fine-needle aspiration: a case report, Christopher L. Owens, Shezad Basaria, and Theresa L. Nicol
Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells, Lu-Ann M. Pozzi, Joseph Walter Maciaszek, and Kenneth L. Rock
Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation, Charles Fenton Towne, Ian A. York, Joost J. Neijssen, Margaret L. Karow, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Jacques J. Neefjes, and Kenneth L. Rock
A mutant cell with a novel defect in MHC class I quality control, Ian A. York, Ethan P. Grant, A. Maria Dahl, and Kenneth L. Rock
Publications from 2004
Mammaglobin and CRxA-01 in pleural effusion cytology: potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7-positive/cytokeratin 20-negative carcinomas, Armando Ciampa, Gary R. Fanger, Ashraf Khan, Kenneth L. Rock, and Bo Xu
Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme, David A. Hill, Simion I. Chiosea, Saha Jamaluddin, Kanaklata Roy, Andrew H. Fischer, Douglas D. Boyd, Jeffrey A. Nickerson, and Anthony N. Imbalzano
Cellular protein is the source of cross-priming antigen in vivo, Lianjun Shen and Kenneth L. Rock
Publications from 2003
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation, Ian A. York, Annie X. Y. Mo, Kristen Lemerise, Wanyong Zeng, Yuelei Shen, Carmela R. Abraham, Tomo Saric, Alfred L. Goldberg, and Kenneth L. Rock
Publications from 2002
Physicians' emotional intelligence and patient satisfaction, Peggy J. Wagner, Ginger C. Mosley, Michael M. Grant, Johnathan R. Gore, and Christopher L. Owens
Publications from 2001
Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones
Anti-peptide antibody blocks peptide binding to MHC class I molecules in the endoplasmic reticulum, Craig J. Hilton, A. Maria Dahl, and Kenneth L. Rock
Absence of hippocampal sclerosis in children with multiple daily seizures since infancy, Sanjeev V. Kothare, Ana Sotrel, Michael Duchowny, Prasanna Jayakar, Paul C. Marshall, and Thomas W. Smith
Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides, Annie X. Y. Mo, Steven F. L. van Lelyveld, Abie Craiu, and Kenneth L. Rock
Publications from 2000
Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations, Christine Margaret Boyle and Harriet L. Robinson
Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses, Yan Shi, Wanyong Zeng, and Kenneth L. Rock
Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation, Luis J. Sigal and Kenneth L. Rock
Publications from 1999
A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis, Dancella M. Fernandes, Allison Michelle Baird, Leslie J. Berg, and Kenneth L. Rock
Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides, Annie X. Y. Mo, Paolo Cascio, Kristen Lemerise, Alfred L. Goldberg, and Kenneth L. Rock
Publications from 1998
The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo, Luis J. Sigal, Hans Reiser, and Kenneth L. Rock
Publications from 1992
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker, John J. Nunnari, Marc Fisher, and Stanley D. T. White