The Department of Orthopedics and Physical Rehabilitation, along with the Division of Rheumatology, form the renowned UMMS/UMMHC Musculoskeletal Center of Excellence. The Center focuses on clinical care and research for the prevention, diagnosis, treatment and rehabilitation of musculoskeletal disorders. Patients have access to preventive, diagnostic, treatment and rehabilitation services for musculoskeletal injuries and disorders. This includes a direct link to the advanced, highly specialized services located on the three UMMS/UMMHC campuses. This collection showcases journal articles and other publicationswritten by faculty and researchers of the Department of Orthopedics and Physical Rehabilitation.

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Publications from 2013

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Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc

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Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization, Pingsheng Liu and Jie Song

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MRI Study of Associated Shoulder Pathology in Patients With Full-thickness Subscapularis Tendon Tears, Xinning Li, Jonathan Fallon, Natalie Egge, Emily J. Curry, Ketan Patel, Brett D. Owens, and Brian D. Busconi

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Esophageal perforation more than 10 years after anterior cervical spine plating, J. Lucas, E. Smith, Mark S. Eskander, James T. McPhee, and Anthony Lapinsky

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Greater Co-morbidity Burden is Associated with Greater Pain and Disability at Time of Total Knee Replacement Among African American Patients, Anthony Porter, Leslie R. Harrold, Lili Chen, Jeroan J. Allison, Philip Noble, David C. Ayers, and Patricia D. Franklin

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A Delphi Exercise to Identify Characteristic Features of Gout -- Opinions from Patients and Physicians, the First Stage in Developing New Classification Criteria, Rebecca L. Prowse and Leslie R. Harrold

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Pre-operative Emotional Health Affects Post-operative Patient Function but not Patient Satisfaction Following Primary Total Hip Arthroplasty, Benjamin Snyder, Wenyun Yang, Anthony Porter, Patricia D. Franklin, and David C. Ayers

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Less common upper limb mononeuropathies, Faren H. Williams and Bryan Kumiga

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Stem cell labeling using polyethylenimine conjugated (alpha-NaYbF4:Tm3+)/CaF2 upconversion nanoparticles, Liang Zhao, Artem Kutikov, Jie Shen, Chunying Duan, Jie Song, and Gang Han

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Tailored system to deliver behavioral intervention and manage data in randomized trials, Hua Zheng, Milagros C. Rosal, Carol A. Oatis, Wenjun Li, and Patricia D. Franklin

Publications from 2012

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Effect of timing of ACL reconstruction in surgery and development of meniscal and chondral lesions, D. Edmund Anstey, Benton E. Heyworth, Mark D. Price, and Thomas J. Gill

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Tantalum versus Titanium Acetabular Shells in Young Active THR Patients: A Radiostereometric Analysis (RSA) Study, David C. Ayers, Marie Walcott, Benjamin Snyder, Michelle E. Aubin, Jacob M. Drew, Peyton L. Hays, Mark S. Eskander, Henrik Machau, and Charles Bragdon

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(alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging, Guanying Chen, Jie Shen, Tymish Y. Ohulchansky, Nayan J. Patel, Artem Kutikov, Zhipeng Li, Jie Song, Ravindra K. Pandey, Hans Agren, Paras N. Prasad, and Gang Han

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(alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging, Guanying Chen, Jie Shen, Tymish Y. Ohulchansky, Nayan J. Patel, Artem Kutikov, Zhipeng Li, Jie Song, Ravindra K. Pandey, Hans Agren, Paras N. Prasad, and Gang Han

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Postoperative infection treatment score for the spine (PITSS): construction and validation of a predictive model to define need for single versus multiple irrigation and debridement for spinal surgical site infection, Christian P. DiPaola, Davor D. Saravanja, Luca Boriani, Hongbin Zhang, Michael C. Boyd, Brian K. Kwon, Scott J. Paquette, Marcel F. S. Dvorak, Charles G. Fisher, and John T. Street

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Comparison of Radiation Exposure During Thoracolumbar Fusion Using Fluoroscopic Guidance versus Anatomic Placement of Pedicle Screws, Natalie Egge, Jeffrey Lange, Christian P. DiPaola, Anthony Lapinsky, Patrick J. Connolly, and Jason C. Eck

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Predictors of Improved Pain, Quality of Life, and Physical Function after Surgical Treatment of Lumbar Spinal Stenosis, Natalie Egge, Anthony Lapinsky, Daniel Mandell, Jason C. Eck, Christian P. DiPaola, Jeffrey Lange, Patrick J. Connolly, and Patricia D. Franklin

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The association between preoperative spinal cord rotation and postoperative C5 nerve palsy, Mark S. Eskander, Steve Balsis, Chris Balinger, Caitlin M. Howard, Nicholas W. Lewing, Jonathan P. Eskander, Michelle E. Aubin, Jeffrey Lange, Jason C. Eck, Patrick J. Connolly, and Louis G. Jenis

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The Varus Knee Reveals Differential Expression Patterns of miRNAs in Spared vs. Non-spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, and Jane B. Lian

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Etiology of Experimental Osteoarthritis: Early Events and Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, and David C. Ayers

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Physician-industry conflict of interest: public opinion regarding industry-sponsored research, Charles G. Fisher, Christian P. DiPaola, Vanessa K. Noonan, Christopher Bailey, and Marcel F. S. Dvorak

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Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement, Patricia D. Franklin, Jeroan J. Allison, and David C. Ayers

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FORCE-TJR: Innovative design for a national TJR comparative effectiveness research database, Patricia D. Franklin, Jeroan J. Allison, Wenjun Li, Leslie R. Harrold, Bruce A. Barton, Benjamin Snyder, Milagros C. Rosal, Norman Weissman, John E. Ware Jr., and David C. Ayers

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Importance of clinically-refined medical and musculoskeletal co-morbidities in registries that evaluate patient-reported outcomes following TKR, Patricia D. Franklin, Wenjun Li, Carol Otis, Benjamin Snyder, Milagros C. Rosal, and David C. Ayers

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Can knee arthroplasty play a role in weight management in knee osteoarthritis, Patricia D. Franklin and Milagros C. Rosal

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A variant of a type V lateral clavicle fracture involving a posteriorly displaced medial segment. A case report, Thomas P. Goss and Xinning Li

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PGE(2) and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways, Marcel Haversath, Isabelle Catelas, Xinning Li, Tjark Tassemeier, and Marcus Jager

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Use of the f-tool for the removal of a bent intramedullary femoral nail with a sagittal plane deformity, Michael J. Heffernan, Walter J. Leclair, and Xinning Li

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Analysis of CT-based navigation system for pedicle screw placement, Scott D. Hodges, Jason C. Eck, and Danette Newton

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Retrospective study of posterior cervical fusions with rhBMP-2, Scott D. Hodges, Jason C. Eck, and Danette Newton

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Patient Flow in Peri-Operative Services: Analysis of Factors that Impact OR Turn Over Time, Shubjeet Kaur, Shimul A. Shah, John J. Wixted, Costin Catalin Negroiu, and Stephen O. Heard

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An evidence-based medicine process to determine outcomes after cervical spine trauma: what surgeons should be telling their patients, Peter Lewkonia, Christian P. DiPaola, Rowan Schouten, Vanessa Noonan, Marcel Dvorak, and Charles G. Fisher

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Intraspinal penetrating stab injury to the middle thoracic spinal cord with no neurologic deficit, Xinning Li, Emily J. Curry, Micah Blais, Richard Ma, and Arno S. Sungarian

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Intraspinal penetrating stab injury to the middle thoracic spinal cord with no neurologic deficit, Xinning Li, Emily J. Curry, Micah Blais, Richard Ma, and Arno S. Sungarian

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pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute, Xinning Li, Jianwen Xu, Tera M. Filion Potts, David C. Ayers, and Jie Song

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The incidence of C5 palsy after multilevel cervical decompression procedures: a review of 750 consecutive cases, Ahmad Nassr, Jason C. Eck, Ravi K. Ponnappan, Rami R. Zanoun, William F. Donaldson III, and James D. Kang

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Evaluation of sterilization methods following contamination of hamstring autograft during anterior cruciate ligament reconstruction, Matthew J. Plante, Xinning Li, Gail Scully, Michael A. Brown, Brian D. Busconi, and Nicola A. DeAngelis

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Three-part head-splitting proximal humerus fracture through a unicameral bone cyst, John A. Younghein, Mark S. Eskander, Nicola A. DeAngelis, and John J. Wixted

Publications from 2011

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Relationship between anthropometric measurements and hamstring autograft diameter in anterior cruciate ligament reconstruction, Catherine B. Boisvert, Michelle E. Aubin, and Nicola A. DeAngelis

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Mechanics of hip arthroscopy, James R. Boyle, Jason A. Silva, Sean McMillan, and Brian D. Busconi

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Preface. A state-of-the-art overview on the treatment of hip injuries, Brian D. Busconi

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Sports-related Injuries of the Hip, Brian D. Busconi

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Introduction to Arthroscopy of the Hip, Brian D. Busconi and Sean McMillan

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Evolutionary Screening of Collagen-like Peptides That Nucleate Hydroxyapatite Crystals, Woo-Jae Chung, Ki-Young Kwon, Jie Song, and Seung-Wuk Lee

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The characteristics of patients with type 1: intraforaminal vertebral artery anomalies, Mark S. Eskander, Michelle E. Aubin, Joshua W. Major, Bree Huning, Jacob M. Drew, Julianne Marvin, and Patrick J. Connolly

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Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds, Tera M. Filion, Artem Kutikov, and Jie Song

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Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats, Tera M. Filion, Xinning Li, April Mason-Savas, Jaclynn M. Kreider, Steven A. Goldstein, David C. Ayers, and Jie Song

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Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Tera M. Filion and Jie Song

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In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites, Tera M. Filion, Jianwen Xu, Manju L. Prasad, and Jie Song

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Gender and BMI Differences in Physical Activity after Total Knee Replacement, Patricia D. Franklin, Wenjun Li, Wenyun Yang, and David C. Ayers

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Removing a patient from the spine board: is the lift and slide safer than the log roll, MaryBeth Horodyski, Bryan P. Conrad, Gianluca Del Rossi, Christian P. DiPaola, and Glen R. Rechtine II

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Cervical collars are insufficient for immobilizing an unstable cervical spine injury, MaryBeth Horodyski, Christian P. DiPaola, Bryan P. Conrad, and Glen R. Rechtine II

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Soft tissue pathology around the hip, Victor M. Ilizaliturri Jr., Javier Camacho-Galindo, Alberto Nayib Evia Ramirez, Yari Lizette Gonzalez Ibarra, Sean McMillan, and Brian D. Busconi

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A synthesis of best available evidence and expert opinion on outcomes after cervical trauma: what should surgeons be telling their patients, Peter Lewkonia, Christian P. DiPaola, Rowan Schouten, Marcel Dvorak, and Charles G. Fisher

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Athletic pubalgia (sports hernia), Demetrius E. M. Litwin, Erica B. Sneider, Patrick M. McEnaney, and Brian D. Busconi

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation, Julie C. Liu, Christopher Joachim Lengner, Tripti Gaur, Yang Lou, Sadiq Hussain, Marci D. Jones, Brent Borodic, Jennifer L. Colby, Heather Anne Steinman, Andre J. Van Wijnen, Janet L. Stein, Stephen N. Jones, Gary S. Stein, and Jane B. Lian (The Journal of biological chemistry)

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Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2, Pingsheng Liu, Jonathan Smits, David C. Ayers, and Jie Song

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Entrapped periosteum preventing reduction of a Salter-Harris II distal tibial fracture in an adolescent patient. MRI and intra-operative findings, Xinning Li, Michelle E. Aubin, Emily J. Curry, and Errol S. Mortimer

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Pseudoaneurysm of the profunda femoris artery following a long anterograde intramedullary nail for an unstable intertrochanteric hip fracture: A case report and review of the literature, Xinning Li, Patricia D. Luckeroth, Emily J. Curry, Mohammad H. Eslami, and Walter J. Leclair

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Muscle Injuries and Avulsions, William Morrison, Brian D. Busconi, Sean McMillan, Kristen McClure, Amy Austin, and Rob Fredericks

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Femoral Acetabular Impingement (Cam and Pincer), William Morrison, John P. Salvo Jr., Brian D. Busconi, and Roxanne Wallace

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Labral Tears, Ligament Teres Injury, and Chondral Injury, William Morrison, John P. Salvo Jr., Brian D. Busconi, and Roxanne Wallace

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Synovial Disorders, William Morrison, John P. Salvo Jr., Brian D. Busconi, Roxanne Wallace, and Sean McMillan

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Arthritis, William Morrison, John P. Salvo Jr., Sean McMillan, and Brian D. Busconi

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Open Reduction and Internal Fixation of Intra-Articular Scapular Fractures, Brett D. Owens, Joanna G. Branstetter, and Thomas P. Goss

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Open Reduction and Internal Fixation of Non-Articular Scapular Fractures, Brett D. Owens and Thomas P. Goss

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Radiology, Ketan Patel, Roxanne Wallace, and Brian D. Busconi

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Clinical diagnosis of hip pain, Matthew Plante, Roxanne Wallace, and Brian D. Busconi

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Proximal Femur Fractures, Mark D. Price, Brian D. Busconi, and Sean McMillan

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A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement, Milagros C. Rosal, David C. Ayers, Wenjun Li, Carol Oatis, Amy Borg, Hua Zheng, and Patricia D. Franklin

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Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry, Jianwen Xu, Tera M. Filion Potts, Fioleda Prifti, and Jie Song

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Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry, Jianwen Xu, Tera M. Filion, Fioleda Prifti, and Jie Song

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A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates), Jianwen Xu, Fioleda Prifti, and Jie Song

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Thermal Responsive Shape Memory Polymers for Biomedical Applications, Jianwen Xu and Jie Song

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Integrating Patient-reported Symptoms in the Arthritis Care Record, Hua Zheng, David C. Ayers, Janel Milner, Wenyun Yang, and Patricia D. Franklin

Publications from 2010

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions, Jacqueline Akech, John J. Wixted, Krystin Bedard, Margaretha Van der Deen, Sadiq Hussain, T. A. Guise, Andre J. Van Wijnen, Janet L. Stein, Lucia R. Languino, Dario C. Altieri, Jitesh Pratap, E. Keller, Gary S. Stein, and Jane B. Lian (Oncogene)

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Identification of type 1: interforaminal vertebral artery anomalies in cervical spine MRIs, Michelle E. Aubin, Mark S. Eskander, Jacob M. Drew, Julianne Marvin, Jonathan P. Eskander, Jason C. Eck, and Patrick J. Connolly

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Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults, Virginia G. Briggs, Wenjun Li, Mark S. Kaplan, Mark S. Eskander, and Patricia D. Franklin

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Effects of magnetic resonance imaging signal change in myelopathic patients: a meta-analysis, Jason C. Eck, Jacob M. Drew, and Bradford L. Currier

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Intradural and epidural abscess presenting as sepsis 2 weeks after uncomplicated lumbar microdiscectomy, Mark S. Eskander, Jacob M. Drew, Michelle E. Aubin, and Jason C. Eck

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Vertebral artery anatomy: a review of two hundred fifty magnetic resonance imaging scans, Mark S. Eskander, Jacob M. Drew, Michelle E. Aubin, Julianne Marvin, Patricia D. Franklin, Jason C. Eck, Nihal Patel, Katherine Boyle, and Patrick J. Connolly

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A modified technique for dowel fibular strut graft placement and circumferential fusion in the setting of L5-S1 spondylolisthesis and multilevel degenerative disc disease, Mark S. Eskander, Jonathan P. Eskander, Jacob M. Drew, Jessica L. Pelow-Aidlen, Mohammad H. Eslami, and Patrick J. Connolly

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Revision strategy for posterior extrusion of the CHARITE polyethylene core, Mark S. Eskander, Ikechukwu I Onyedika, Jonathan P. Eskander, Patrick J. Connolly, Jason C. Eck, and Anthony Lapinsky

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A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group, Charles G. Fisher, Christian P. DiPaola, Timothy C. Ryken, Mark H. Bilsky, Christopher I. Shaffrey, Sigurd H. Berven, James S. Harrop, Michael G. Fehlings, Stefano Boriani, Dean Chou, Meic H. Schmidt, David W. Polly, Roberto Biagini, Shane Burch, Mark B. Dekutoski, Aruna Ganju, Peter C. Gerszten, Ziya L. Gokaslan, Michael W. Groff, Norbert J. Liebach, Ehud Mendel, Scott H. Okuno, Shreyaskumar Patel, Laurence D. Rhines, Peter S. Rose, Daniel M. Sciubba, Narayan Sundaresan, Katsuro Tomita, Peter P. Varga, Luiz R. Vialle, Frank D. Vrionis, Yoshiya Yamada, and Daryl R. Fourney

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Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction, Patricia D. Franklin, John A. Karbassi, Wenjun Li, Wenyun Yang, and David C. Ayers

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Multiple glomus tumors of the lower leg, Katrina N. Glazebrook, Mathew J. Most, Terry K. Schiefer, Carrie Y. Inwards, and Franklin H. Sim

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Cell therapy in bone healing disorders, Marcus Jager, Philippe Hernigou, Christoph Zilkens, Monika Herten, Xinning Li, Johannes Fischer, and Rudiger Krauspe

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A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes, Marci D. Jones, Julie C. Liu, Thomas K. Barthel, Sadiq Hussain, Erik Lovria, Dengfeng Cheng, Jesse A. Schoonmaker, Sudhanshu Mulay, David C. Ayers, Mary L. Bouxsein, Gary S. Stein, Siddhartha Mukherjee, and Jane B. Lian (Clinical cancer research : an official journal of the American Association for Cancer Research)

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Medial pelvic migration of the lag screw in a short gamma nail after hip fracture fixation: a case report and review of the literature, Xinning Li, Michael J. Heffernan, Christina Kane, and Walter J. Leclair

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Upper extremity stress fractures and spondylolysis in an adolescent baseball pitcher with an associated endocrine abnormality: a case report, Xinning Li, Michael J. Heffernan, and Errol S. Mortimer

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Management of type II superior labrum anterior posterior lesions: a review of the literature, Xinning Li, Timothy J. Lin, Marcus Jager, Mark D. Price, Nicola Deangelis, Brian D. Busconi, and Michael A. Brown

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Lumbar and sacral radiofrequency neurotomy, David A. Mazin and Joseph P. Sullivan

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Biomechanical investigation of a novel ratcheting arthrodesis nail, Jeremy J. McCormick, Xinning Li, Douglas R. Weiss, Kristen L. Billiar, and John J. Wixted

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Osteofibrous dysplasia and adamantinoma, Mathew J. Most, Franklin H. Sim, and Carrie Y. Inwards

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The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss, Jitesh Pratap, Jacqueline Akech, John J. Wixted, Gabriela Szabo, Sadiq Hussain, Meghan E. McGee-Lawrence, Xiaodong Li, Krystin Bedard, Robinder J. Dhillon, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jennifer J. Westendorf, and Jane B. Lian (Molecular cancer therapeutics)

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Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles, Christine A. St. Pierre, Melvin Chan, Yoichiro Iwakura, David C. Ayers, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Arachidonic acid, eicosanoids, and fracture repair, John J. Wixted, Paul J. Fanning, Ian Rothkopf, Gary S. Stein, and Jane B. Lian

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High performance shape memory polymer networks based on rigid nanoparticle cores, Jianwen Xu and Jie Song

Publications from 2009

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Arthroscopic treatment of concomitant superior labral anterior posterior (SLAP) lesions and rotator cuff tears in patients over the age of 45 years, Amy E. Abbot, Xinning Li, and Brian D. Busconi

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Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients, David C. Ayers, Peyton L. Hays, Jacob M. Drew, Mark S. Eskander, Daniel Osuch, and Charles R. Bragdon