The Department of Orthopedics and Physical Rehabilitation, along with the Division of Rheumatology, form the renowned UMMS/UMMHC Musculoskeletal Center of Excellence. The Center focuses on clinical care and research for the prevention, diagnosis, treatment and rehabilitation of musculoskeletal disorders. Patients have access to preventive, diagnostic, treatment and rehabilitation services for musculoskeletal injuries and disorders. This includes a direct link to the advanced, highly specialized services located on the three UMMS/UMMHC campuses.

This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Orthopedics and Physical Rehabilitation.

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Publications from 2011

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Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry, Jianwen Xu, Tera M. Filion, Fioleda Prifti, and Jie Song

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A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates), Jianwen Xu, Fioleda Prifti, and Jie Song

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Thermal Responsive Shape Memory Polymers for Biomedical Applications, Jianwen Xu and Jie Song

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Integrating Patient-reported Symptoms in the Arthritis Care Record, Hua Zheng, David C. Ayers, Janel Milner, Wenyun Yang, and Patricia D. Franklin

Publications from 2010

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions, Jacqueline Akech, John J. Wixted, Krystin Bedard, Margaretha Van der Deen, Sadiq Hussain, T. A. Guise, Andre J. Van Wijnen, Janet L. Stein, Lucia R. Languino, Dario C. Altieri, Jitesh Pratap, E. Keller, Gary S. Stein, and Jane B. Lian

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Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults, Virginia G. Briggs, Wenjun Li, Mark S. Kaplan, Mark S. Eskander, and Patricia D. Franklin

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Effects of magnetic resonance imaging signal change in myelopathic patients: a meta-analysis, Jason C. Eck, Jacob M. Drew, and Bradford L. Currier

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Intradural and epidural abscess presenting as sepsis 2 weeks after uncomplicated lumbar microdiscectomy, Mark S. Eskander, Jacob M. Drew, Michelle E. Aubin, and Jason C. Eck

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Vertebral artery anatomy: a review of two hundred fifty magnetic resonance imaging scans, Mark S. Eskander, Jacob M. Drew, Michelle E. Aubin, Julianne Marvin, Patricia D. Franklin, Jason C. Eck, Nihal Patel, Katherine Boyle, and Patrick J. Connolly

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A modified technique for dowel fibular strut graft placement and circumferential fusion in the setting of L5-S1 spondylolisthesis and multilevel degenerative disc disease, Mark S. Eskander, Jonathan P. Eskander, Jacob M. Drew, Jessica L. Pelow-Aidlen, Mohammad H. Eslami, and Patrick J. Connolly

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Revision strategy for posterior extrusion of the CHARITE polyethylene core, Mark S. Eskander, Ikechukwu I Onyedika, Jonathan P. Eskander, Patrick J. Connolly, Jason C. Eck, and Anthony Lapinsky

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A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group, Charles G. Fisher, Christian P. DiPaola, Timothy C. Ryken, Mark H. Bilsky, Christopher I. Shaffrey, Sigurd H. Berven, James S. Harrop, Michael G. Fehlings, Stefano Boriani, Dean Chou, Meic H. Schmidt, David W. Polly, Roberto Biagini, Shane Burch, Mark B. Dekutoski, Aruna Ganju, Peter C. Gerszten, Ziya L. Gokaslan, Michael W. Groff, Norbert J. Liebach, Ehud Mendel, Scott H. Okuno, Shreyaskumar Patel, Laurence D. Rhines, Peter S. Rose, Daniel M. Sciubba, Narayan Sundaresan, Katsuro Tomita, Peter P. Varga, Luiz R. Vialle, Frank D. Vrionis, Yoshiya Yamada, and Daryl R. Fourney

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Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction, Patricia D. Franklin, John A. Karbassi, Wenjun Li, Wenyun Yang, and David C. Ayers

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Multiple glomus tumors of the lower leg, Katrina N. Glazebrook, Mathew J. Most, Terry K. Schiefer, Carrie Y. Inwards, and Franklin H. Sim

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Cell therapy in bone healing disorders, Marcus Jager, Philippe Hernigou, Christoph Zilkens, Monika Herten, Xinning Li, Johannes Fischer, and Rudiger Krauspe

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A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes, Marci D. Jones, Julie C. Liu, Thomas K. Barthel, Sadiq Hussain, Erik Lovria, Dengfeng Cheng, Jesse A. Schoonmaker, Sudhanshu Mulay, David C. Ayers, Mary L. Bouxsein, Gary S. Stein, Siddhartha Mukherjee, and Jane B. Lian

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Medial pelvic migration of the lag screw in a short gamma nail after hip fracture fixation: a case report and review of the literature, Xinning Li, Michael J. Heffernan, Christina Kane, and Walter J. Leclair

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Upper extremity stress fractures and spondylolysis in an adolescent baseball pitcher with an associated endocrine abnormality: a case report, Xinning Li, Michael J. Heffernan, and Errol S. Mortimer

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Management of type II superior labrum anterior posterior lesions: a review of the literature, Xinning Li, Timothy J. Lin, Marcus Jager, Mark D. Price, Nicola Deangelis, Brian D. Busconi, and Michael A. Brown

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Lumbar and sacral radiofrequency neurotomy, David A. Mazin and Joseph P. Sullivan

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Biomechanical investigation of a novel ratcheting arthrodesis nail, Jeremy J. McCormick, Xinning Li, Douglas R. Weiss, Kristen L. Billiar, and John J. Wixted

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Osteofibrous dysplasia and adamantinoma, Mathew J. Most, Franklin H. Sim, and Carrie Y. Inwards

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The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss, Jitesh Pratap, Jacqueline Akech, John J. Wixted, Gabriela Szabo, Sadiq Hussain, Meghan E. McGee-Lawrence, Xiaodong Li, Krystin Bedard, Robinder J. Dhillon, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jennifer J. Westendorf, and Jane B. Lian

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Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles, Christine A. St. Pierre, Melvin Chan, Yoichiro Iwakura, David C. Ayers, Evelyn A. Kurt-Jones, and Robert W. Finberg

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Arachidonic acid, eicosanoids, and fracture repair, John J. Wixted, Paul J. Fanning, Ian Rothkopf, Gary S. Stein, and Jane B. Lian

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High performance shape memory polymer networks based on rigid nanoparticle cores, Jianwen Xu and Jie Song

Publications from 2009

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Arthroscopic treatment of concomitant superior labral anterior posterior (SLAP) lesions and rotator cuff tears in patients over the age of 45 years, Amy E. Abbot, Xinning Li, and Brian D. Busconi

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Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients, David C. Ayers, Peyton L. Hays, Jacob M. Drew, Mark S. Eskander, Daniel Osuch, and Charles R. Bragdon

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Intermediate outcomes after primary traumatic anterior shoulder dislocation in skeletally immature patients aged 10 to 13 years, Keith Cordischi, Xinning Li, and Brian D. Busconi

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Cervical spine motion generated with manual versus jackson table turning methods in a cadaveric c1-c2 global instability model, Christian P. DiPaola, Bryan P. Conrad, MaryBeth Horodyski, Matthew J. DiPaola, Andrew Sawers, and Glen R. Rechtine II

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Endobutton-assisted repair of complete distal biceps tendon rupture in a woman, Jason C. Eck and Seth D. Baublitz

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En Bloc Resection of Primary Spinal Tumors, Jason C. Eck and Mark B. Dekutoski

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Sacrectomy and Spinopelvic Reconstruction, Jason C. Eck, Michael J. Yaszemski, and Franklin H. Sim

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Injury of an aberrant vertebral artery during a routine corpectomy: a case report and literature review, Mark S. Eskander, Patrick J. Connolly, Jonathan P. Eskander, and D. D. Brooks

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E-Health Strategies to Support Adherence, Patricia D. Franklin, Ramesh Farzanfar, and Deborah D. Thompson

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Secreted frizzled related protein 1 is a target to improve fracture healing, Tripti Gaur, John J. Wixted, Sadiq Hussain, Shannon L. O'Connell, Elise F. Morgan, David C. Ayers, Barry S. Komm, Peter V. N. Bodine, Gary S. Stein, and Jane B. Lian

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Traumatic thoracic spondyloptosis without neurologic deficit, and treatment with in situ fusion, Alex Gitelman, Mathew J. Most, and Mark Stephen

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Medial patellofemoral ligament injury patterns and associated pathology in lateral patella dislocation: an MRI study, Patrick Guerrero, Xinning Li, Ketan Patel, Michael Brown, and Brian D. Busconi

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Comparison of the flat torso versus the elevated torso shoulder pad removal techniques in a cadaveric cervical spine instability model, MaryBeth Horodyski, Christian P. DiPaola, Matthew J. DiPaola, Bryan P. Conrad, Gianluca Del Rossi, and Glen R. Rechtine II

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Controversies in the treatment of cervical spine dislocations, Joon Y. Lee, Ahmad Nassr, Jason C. Eck, and Alexander R. Vaccaro

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Anatomical reconstruction for chronic lateral ankle instability in the high-demand athlete: functional outcomes after the modified Brostrom repair using suture anchors, Xinning Li, Heather Killie, Patrick Guerrero, and Brian D. Busconi

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Does incorrect level needle localization during anterior cervical discectomy and fusion lead to accelerated disc degeneration, Ahmad Nassr, Joon Y. Lee, Rubin S. Bashir, Jeffrey A. Rihn, Jason C. Eck, James D. Kang, and Moe R. Lim

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Gender differences in osteoarthritis, Mark D. Price and James H. Herndon

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Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications, Jie Song, Jianwen Xu, Tera M. Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi

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Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera, James Su, Elena Iomdina, Elena Tarutta, Brian Ward, Jie Song, and Christine F. Wildsoet

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Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor, John J. Wixted, Paul J. Fanning, Tripti Gaur, Shannon L. O'Connell, Jason Silva, April Mason-Savas, David C. Ayers, Gary S. Stein, and Jane B. Lian

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Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute, Jianwen Xu, Xinning Li, Jane B. Lian, David C. Ayers, and Jie Song

Publications from 2008

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Ankle fractures in the elderly: initial and long-term outcomes, Sarah A. Anderson, Xinning Li, Patricia D. Franklin, and John J. Wixted

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The risk of reintubation following anterior cervical spine surgery, Dahari Brooks, Mark S. Eskander, Jonathan Eskander, Patricia D. Franklin, Patrick J. Connolly, Henry Claude Sagi, and K. Daniel Riew

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The proximal biceps tendon: tricks and pearls, Brian D. Busconi, Nicola Deangelis, and Patrick Guerrero

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Relationship of the internal carotid artery to the anterior aspect of the C1 vertebra: implications for C1-C2 transarticular and C1 lateral mass fixation, Bradford L. Currier, Tim P. Maus, Jason C. Eck, Dirk R. Larson, and Michael J. Yaszemski

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Fixation strength of unicortical versus bicortical C1-C2 transarticular screws, Steven J. Cyr, Bradford L. Currier, Jason C. Eck, Andrew Foy, Qingshan Chen, Dirk R. Larson, Michael J. Yaszemski, and Kai-Nan An

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Use of the trauma pelvic orthotic device (T-POD) for provisional stabilisation of anterior-posterior compression type pelvic fractures: a cadaveric study, Nicola Deangelis, John J. Wixted, Jacob M. Drew, Mark S. Eskander, Jonathan P. Eskander, and Bruce G. French

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Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a meta-analysis of the literature, Jason C. Eck, Dean Nachtigall, S. Craig Humphreys, and Scott D. Hodges

Delayed presentation of metastatic melanoma of the cervical spine, Jason C. Eck, Marc A. Tressler, and Steven J. Triantafyllou

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A left knee wound complication by non-Hodgkins lymphoma in bilateral total knee arthroplasties, Mark S. Eskander, Erika McPhee, Jonathan P. Eskander, Robert Nascimento, Jeremy J. McCormick, Suyang Hao, David Shepro, and Kirk Johnson

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Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants, Jonathan B. Fitzgerald, Moonsoo Jin, Diana H. Chai, Patrick Siparsky, Paul J. Fanning, and Alan J. Grodzinsky

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The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes, Patricia D. Franklin, Wenjun Li, and David C. Ayers

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Hyperthermia associated osteonecrosis in young patients with pelvic malignancies, Marcus Jager, Stefan Balzer, Rudiger Wessalowski, J. Schaper, Ulrich Gobel, Xinning Li, and Rudiger Krauspe

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Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro, Marcus Jager, Johannes Fischer, Wiebke Dohrn, Xinning Li, David C. Ayers, Akos Czibere, Wolf Christian Prall, Sabine Lensing-Hohn, and Rudiger Krauspe

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Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro, Marcus Jager, F. Urselmann, F. Witte, K. Zanger, Xinning Li, David C. Ayers, and Rudiger Krauspe

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Intravascular uptake during fluoroscopically guided cervical interlaminar steroid injection at C6-7: a case report, Mark S. Kaplan, Joseph Cunniff, John Cooke, and Jeremy Giere Collins

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Arthroscopic debridement of the osteoarthritic knee combined with hyaluronic acid (Orthovisc(R)) treatment: A case series and review of the literature, Xinning Li, Agam Shah, Patricia D. Franklin, Renee J. Merolli, Jill Bradley, and Brian D. Busconi

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An improved murine femur fracture device for bone healing studies, Joseph E. Marturano, Benjamin C. Cleveland, Melissa A. Bryne, Shannon L. O'Connell, John J. Wixted, and Kristen L. Billiar

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Imaging in pelvic osteomyelitis: support for early magnetic resonance imaging, Erika McPhee, Jonathan P. Eskander, Mark S. Eskander, Susan T. Mahan, and Errol Mortimer

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells, Jitesh Pratap, John J. Wixted, Tripti Gaur, Sayyed K. Zaidi, Jason Dobson, Karthiga Devi Gokul, Sadiq Hussain, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Urgent surgical decompression compared to methylprednisolone for the treatment of acute spinal cord injury: a randomized prospective study in beagle dogs, Richard S. Rabinowitz, Jason C. Eck, C. Michel Harper Jr., Dirk R. Larson, Miguel A. Jimenez, Joseph E. Parisi, Jonathan A. Friedman, Michael J. Yaszemski, and Bradford L. Currier

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Reuse of external fixation components: a randomized trial, Jinsil K. Sung, Rafael Levin, Jodi Siegel, Thomas A. Einhorn, William R. Creevy, and Paul Tournetta III

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Computer-aided surgery: assessing the accuracy of a navigation system, Douglas R. Weiss, John J. Wixted, and Richard C. Anderson

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Paecilomyces lilacinus olecranon bursitis in an immunocompromised host: case report and review, Mireya Wessolossky, John P. Haran, and Kaushik Bagchi

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Neuromuscular complications of nutritional deficiencies, Faren H. Williams

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The effect of an orthopedic trauma room on after-hours surgery at a level one trauma center, John J. Wixted, Mark A. Reed, Mark S. Eskander, Bryce Millar, Richard C. Anderson, Kaushik Bagchi, Shubjeet Kaur, Patricia D. Franklin, and Walter J. Leclair

Publications from 2007

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Imaging assessment of lumbar pedicle screw placement: sensitivity and specificity of plain radiographs and computer axial tomography, Dahari Brooks, Mark S. Eskander, Steve Balsis, Nat Ordway, and Patrick J. Connolly

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Understanding the superior clear space in the adult ankle, Joseph P. Deangelis, Richard C. Anderson, and Nicola Deangelis

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Does medial tenderness predict deep deltoid ligament incompetence in supination-external rotation type ankle fractures, Nicola Deangelis, Mark S. Eskander, and Bruce G. French

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Analysis of pedicle and translaminar facet fixation in a multisegment interbody fusion model, Mark S. Eskander, Dahari Brooks, Nat Ordway, Elizabeth Dale, and Patrick J. Connolly

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Worksite e-mail health promotion trial: Early lessons, Patricia D. Franklin, Robert Ploutz-Snyder, Paula F. Rosenbaum, Michael P. Carey, Nancy Smith, and Michael F. Roizen

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Primary repair of knee dislocations: results in 25 patients (28 knees) at a mean follow-up of four years, Brett D. Owens, Mark Neault, Emily Benson, and Brian D. Busconi

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A chemical and engineering approach towards "smart" synthetic bone grafts, Jie Song

Publications from 2006

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Pilot study of methods to document quantity and variation of independent patient exercise and activity after total knee arthroplasty, Patricia D. Franklin, Joseph McLaughlin, Catherine B. Boisvert, Wenjun Li, and David C. Ayers

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Using sequential e-mail messages to promote health behaviors: evidence of feasibility and reach in a worksite sample, Patricia D. Franklin, Paula F. Rosenbaum, Michael P. Carey, and Michael F. Roizen

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Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation, Tripti Gaur, Lillian Rich, Christopher J. Lengner, Sadiq Hussain, Brune Trevant, David C. Ayers, Janet L. Stein, Peter V. N. Bodine, Barry S. Komm, Gary S. Stein, and Jane B. Lian

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Nanomechanical analysis of bone tissue engineering scaffolds, Jessica D. Kaufman, Jie Song, and Catherine M. Klapperich

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The floating shoulder, B. D. Owens and Thomas P. Goss

Arthroscopy for hip dislocation and fracture-dislocation, Brett D. Owens and Brian D. Busconi

Publications from 2005

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Total knee replacement outcome and coexisting physical and emotional illness, David C. Ayers, Patricia D. Franklin, Robert Ploutz-Snyder, and Catherine B. Boisvert

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The posterior shearing tibial plateau fracture: treatment and results via a posterior approach, Timothy Bhattacharyya, L. Pearce McCarty 3rd, Mitchell B. Harris, Suzanne M. Morrison, John J. Wixted, Mark S. Vrahas, and R. Malcolm Smith

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Neuromuscular rehabilitation and electrodiagnosis. 4. Pediatric issues, Chong-Tae Kim, Jeffrey A. Strommen, Jeffery S. Johns, Jay M. Weiss, Lyn D. Weiss, Faren H. Williams, and Ira G. Rashbaum

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Neuromuscular rehabilitation and electrodiagnosis. 4. Pediatric issues, Chong-Tae Kim, Jeffrey A. Strommen, Jeffery S. Johns, Jay M. Weiss, Lyn D. Weiss, Faren H. Williams, and Ira G. Rashbaum

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Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone, Jie Song, Viengkham Malathong, and Carolyn R. Bertozzi

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Neuromuscular rehabilitation and electrodiagnosis. 3. Diseases of muscles and neuromuscular junction, Jeffrey A. Strommen, Jeffery S. Johns, Chong-Tae Kim, Faren H. Williams, Lyn D. Weiss, Jay M. Weiss, and Ira G. Rashbaum

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Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings, Antoni P. Tomsia, Eduardo Saiz, Jie Song, and Carolyn R. Bertozzi

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Neuromuscular rehabilitation and electrodiagnosis. 2. Peripheral neuropathy, Lyn D. Weiss, Jay M. Weiss, Jeffery S. Johns, Jeffrey A. Strommen, Chong-Tae Kim, Faren H. Williams, and Ira G. Rashbaum

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The effect of valgus/varus malalignment on load distribution in total knee replacements, Frederick W. Werner, David C. Ayers, Lorin P. Maletsky, and Paul J. Rullkoetter

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Neuromuscular rehabilitation and electrodiagnosis. 1. Mononeuropathy, Faren H. Williams, Jeffery S. Johns, Jay M. Weiss, Lyn D. Weiss, Chong-Tae Kim, Jeffrey A. Strommen, and Ira G. Rashbaum

Publications from 2004

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Psychological attributes of preoperative total joint replacement patients: implications for optimal physical outcome, David C. Ayers, Patricia D. Franklin, Paula M. Trief, Robert Ploutz-Snyder, and Deborah Freund

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Functional lipid microstructures immobilized on a gold electrode for voltammetric biosensing of cholera toxin, Quan Cheng, Shimin Zhu, Jie Song, and Na Zhang

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Anatomy of the superficial peroneal nerve in relation to fixation of tibia fractures with the less invasive stabilization system, Joseph P. Deangelis, Nicola Deangelis, and Richard C. Anderson

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Extraarticular synovial chondromatosis: review of epidemiology, imaging studies, microscopy and pathogenesis, with a report of an additional case in a child, Emily Ko, Errol Mortimer, and Armando E. Fraire

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Early cementing does not increase debond energy of grit blasted interfaces, Kenneth A. Mann, Leatha A. Damron, Amos Race, and David C. Ayers