The Department of Orthopedics and Physical Rehabilitation, along with the Division of Rheumatology, form the renowned UMMS/UMMHC Musculoskeletal Center of Excellence. The Center focuses on clinical care and research for the prevention, diagnosis, treatment and rehabilitation of musculoskeletal disorders. Patients have access to preventive, diagnostic, treatment and rehabilitation services for musculoskeletal injuries and disorders. This includes a direct link to the advanced, highly specialized services located on the three UMMS/UMMHC campuses.

This collection showcases journal articles and other publications and presentations written by faculty and researchers of the Department of Orthopedics and Physical Rehabilitation.

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Publications from 2014

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Preoperative Pain and Function Profiles Reflect Consistent TKA Patient Selection Among US Surgeons, David Ayers, Wenjun Li, Leslie Harrold, Jeroan J. Allison, and Patricia D. Franklin

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Changes in Patient Reported Symptoms During the Natural Progression of Osteoarthritis, Matthew C. DeWolf, Patty S. Freedson, David C. Ayers, and Patricia D. Franklin

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Novel Methodology for Using Radiostereometric Analysis to Monitor Fracture Healing, Peter K. Garas, Erik Lovria, and John J. Wixted

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The comparative effectiveness of abatacept versus anti-tumour necrosis factor switching for rheumatoid arthritis patients previously treated with an anti-tumour necrosis factor, Leslie R. Harrold, George W. Reed, Joel M. Kremer, Jeffrey R. Curtis, Daniel H. Solomon, Marc C. Hochberg, and Jeffrey D. Greenberg

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Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs, Daniel H. Solomon, Joel M. Kremer, Mark Fisher, Jeffrey R. Curtis, Victoria Furer, Leslie R. Harrold, Marc C. Hochberg, George W. Reed, Peter Tsao, and Jeffrey D. Greenberg

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Association of medication beliefs and self-efficacy with adherence in urban Hispanic and African-American rheumatoid arthritis patients, Tanya M. Spruill, Gbenga Ogedegbe, Leslie R. Harrold, Jeffrey Potter, Jose U. Scher, Pamela B. Rosenthal, and Jeffrey D. Greenberg

Publications from 2013

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The patient’s perspective of gout, Romy Aranguiz and Leslie R. Harrold

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Validity of diagnostic codes and prevalence of psoriasis and psoriatic arthritis in a managed care population, 1996-2009, Maryam M. Asgari, Jashin J. Wu, Joel M. Gelfand, Craig Salman, Jeffrey R. Curtis, Leslie R. Harrold, and Lisa J. Herrinton

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Improve care through outcomes reporting, David C. Ayers and Patricia D. Franklin

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The role of emotional health in functional outcomes after orthopaedic surgery: extending the biopsychosocial model to orthopaedics: AOA critical issues, David C. Ayers, Patricia D. Franklin, and David C. Ring

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Clinical Profile and Disability Levels of Younger vs. Older TKR and THR Patients in a National Research Consortium, David C. Ayers, Leslie R. Harrold, Benjamin Snyder, Sharina D. Person, and Patricia D. Franklin

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Patient-reported outcomes after total knee replacement vary on the basis of preoperative coexisting disease in the lumbar spine and other nonoperatively treated joints: the need for a musculoskeletal comorbidity index, David C. Ayers, Wenjun Li, Carol Oatis, Milagros C. Rosal, and Patricia D. Franklin

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Integrating Patient-reported Outcomes Into Orthopaedic Clinical Practice: Proof of Concept From FORCE-TJR, David C. Ayers, Hua Zheng, and Patricia D. Franklin

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Patient perspectives on achieving treat-to-target goals: a critical examination of patient-reported outcomes, Jeffrey R. Curtis, Ying Shan, Leslie R. Harrold, Jie Zhang, Jeffrey D. Greenberg, and George W. Reed

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Setting Proper Matrices for Accelerometry-based Physical Activity Measures in Older Women, Rachel Duckham, Scott Crouter, Linda C. Churchill, Kevin J. Kane, Patricia D. Franklin, and Wenjun Li

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Does intraoperative neurophysiological monitoring have predictive value for functional recovery following spinal cord injury? A case report, Jason C. Eck, Christopher J. Martin, Anthony Lapinsky, Patrick J. Connolly, and Christian P. DiPaola

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Incorporating Patient-reported Outcomes in Total Joint Arthroplasty Registries: Challenges and Opportunities, Patricia D. Franklin, Leslie R. Harrold, and David C. Ayers

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Level of Pain and Disability at Time of TKR across the Past 10 Years: Results from Two National Cohorts, Patricia D. Franklin, Leslie R. Harrold, Benjamin Snyder, Courtland Lewis, Philip C. Noble, and David C. Ayers

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Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis, Jeffrey D. Greenberg, Tanya M. Spruill, Ying Shan, George W. Reed, Joel M. Kremer, Jeffrey Potter, Yusuf Yazici, Gbenga Ogedegbe, and Leslie R. Harrold

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New developments in gout, Leslie R. Harrold

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Cost-related Medication Nonadherence in Older Patients with Rheumatoid Arthritis, Leslie R. Harrold, Becky A. Briesacher, Daniel J. Peterson, Ashley J. Beard, Jeanne M. Madden, Fang Zhang, Jerry H. Gurwitz, and Stephen B. Soumerai

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Differences Between Women and Men Undergoing TKR and THR in a National Research Consortium, Leslie R. Harrold, Patricia D. Franklin, Wenjun Li, Courtland Lewis, Benjamin Snyder, Milagros C. Rosal, and David C. Ayers

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Primary care providers' knowledge, beliefs and treatment practices for gout: results of a physician questionnaire, Leslie R. Harrold, Kathleen M. Mazor, Amarie Negron, Jessica Ogarek, Cassandra L. Firneno, and Robert A. Yood

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Incidence and Prevalence of Juvenile Idiopathic Arthritis Among Children in a Managed Care Population, 1996-2009, Leslie R. Harrold, Craig Salman, Stanford Shoor, Jeffrey R. Curtis, Maryam M. Asgari, Joel M. Gelfand, Jashin J. Wu, and Lisa J. Herrinton

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Association between anti-TNF-alpha therapy and interstitial lung disease, Lisa J. Herrinton, Leslie R. Harrold, Liyan Liu, Marsha A. Raebel, Ananse Taharka, Kevin L. Winthrop, Daniel H. Solomon, Jeffrey R. Curtis, James D. Lewis, and Kenneth G. Saag

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Race and Elective Joint Replacement: Where a Disparity Meets Patient Preference, Said A. Ibrahim and Patricia D. Franklin

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An amphiphilic degradable polymer/hydroxyapatite composite with enhanced handling characteristics promotes osteogenic gene expression in bone marrow stromal cells, Artem B. Kutikov and Jie Song

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Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery, Jeffrey Lange, Andrew Karellas, John Street, Jason C. Eck, Anthony Lapinsky, Patrick J. Connolly, and Christian P. DiPaola

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Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization, Pingsheng Liu and Jie Song

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MRI Study of Associated Shoulder Pathology in Patients With Full-thickness Subscapularis Tendon Tears, Xinning Li, Jonathan Fallon, Natalie Egge, Emily J. Curry, Ketan Patel, Brett D. Owens, and Brian D. Busconi

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Esophageal perforation more than 10 years after anterior cervical spine plating, J. Lucas, E. Smith, Mark S. Eskander, James T. McPhee, and Anthony Lapinsky

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Greater Co-morbidity Burden is Associated with Greater Pain and Disability at Time of Total Knee Replacement Among African American Patients, Anthony Porter, Leslie R. Harrold, Lili Chen, Jeroan J. Allison, Philip Noble, David C. Ayers, and Patricia D. Franklin

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A Delphi Exercise to Identify Characteristic Features of Gout -- Opinions from Patients and Physicians, the First Stage in Developing New Classification Criteria, Rebecca L. Prowse and Leslie R. Harrold

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Pre-operative Emotional Health Affects Post-operative Patient Function but not Patient Satisfaction Following Primary Total Hip Arthroplasty, Benjamin Snyder, Wenyun Yang, Anthony Porter, Patricia D. Franklin, and David C. Ayers

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Less common upper limb mononeuropathies, Faren H. Williams and Bryan Kumiga

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Stem cell labeling using polyethylenimine conjugated (alpha-NaYbF4:Tm3+)/CaF2 upconversion nanoparticles, Liang Zhao, Artem Kutikov, Jie Shen, Chunying Duan, Jie Song, and Gang Han

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Tailored system to deliver behavioral intervention and manage data in randomized trials, Hua Zheng, Milagros C. Rosal, Carol A. Oatis, Wenjun Li, and Patricia D. Franklin

Publications from 2012

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Effect of timing of ACL reconstruction in surgery and development of meniscal and chondral lesions, D. Edmund Anstey, Benton E. Heyworth, Mark D. Price, and Thomas J. Gill

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Tantalum versus Titanium Acetabular Shells in Young Active THR Patients: A Radiostereometric Analysis (RSA) Study, David C. Ayers, Marie Walcott, Benjamin Snyder, Michelle E. Aubin, Jacob M. Drew, Peyton L. Hays, Mark S. Eskander, Henrik Machau, and Charles Bragdon

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(alpha-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging, Guanying Chen, Jie Shen, Tymish Y. Ohulchansky, Nayan J. Patel, Artem Kutikov, Zhipeng Li, Jie Song, Ravindra K. Pandey, Hans Agren, Paras N. Prasad, and Gang Han

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Postoperative infection treatment score for the spine (PITSS): construction and validation of a predictive model to define need for single versus multiple irrigation and debridement for spinal surgical site infection, Christian P. DiPaola, Davor D. Saravanja, Luca Boriani, Hongbin Zhang, Michael C. Boyd, Brian K. Kwon, Scott J. Paquette, Marcel F. S. Dvorak, Charles G. Fisher, and John T. Street

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Comparison of Radiation Exposure During Thoracolumbar Fusion Using Fluoroscopic Guidance versus Anatomic Placement of Pedicle Screws, Natalie Egge, Jeffrey Lange, Christian P. DiPaola, Anthony Lapinsky, Patrick J. Connolly, and Jason C. Eck

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Predictors of Improved Pain, Quality of Life, and Physical Function after Surgical Treatment of Lumbar Spinal Stenosis, Natalie Egge, Anthony Lapinsky, Daniel Mandell, Jason C. Eck, Christian P. DiPaola, Jeffrey Lange, Patrick J. Connolly, and Patricia D. Franklin

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The association between preoperative spinal cord rotation and postoperative C5 nerve palsy, Mark S. Eskander, Steve Balsis, Chris Balinger, Caitlin M. Howard, Nicholas W. Lewing, Jonathan P. Eskander, Michelle E. Aubin, Jeffrey Lange, Jason C. Eck, Patrick J. Connolly, and Louis G. Jenis

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The Varus Knee Reveals Differential Expression Patterns of miRNAs in Spared vs. Non-spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, and Jane B. Lian

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Etiology of Experimental Osteoarthritis: Early Events and Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, and David C. Ayers

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Physician-industry conflict of interest: public opinion regarding industry-sponsored research, Charles G. Fisher, Christian P. DiPaola, Vanessa K. Noonan, Christopher Bailey, and Marcel F. S. Dvorak

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Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement, Patricia D. Franklin, Jeroan J. Allison, and David C. Ayers

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FORCE-TJR: Innovative design for a national TJR comparative effectiveness research database, Patricia D. Franklin, Jeroan J. Allison, Wenjun Li, Leslie R. Harrold, Bruce A. Barton, Benjamin Snyder, Milagros C. Rosal, Norman Weissman, John E. Ware Jr., and David C. Ayers

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Importance of clinically-refined medical and musculoskeletal co-morbidities in registries that evaluate patient-reported outcomes following TKR, Patricia D. Franklin, Wenjun Li, Carol Otis, Benjamin Snyder, Milagros C. Rosal, and David C. Ayers

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Can knee arthroplasty play a role in weight management in knee osteoarthritis, Patricia D. Franklin and Milagros C. Rosal

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A variant of a type V lateral clavicle fracture involving a posteriorly displaced medial segment. A case report, Thomas P. Goss and Xinning Li

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PGE(2) and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways, Marcel Haversath, Isabelle Catelas, Xinning Li, Tjark Tassemeier, and Marcus Jager

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Use of the f-tool for the removal of a bent intramedullary femoral nail with a sagittal plane deformity, Michael J. Heffernan, Walter J. Leclair, and Xinning Li

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Analysis of CT-based navigation system for pedicle screw placement, Scott D. Hodges, Jason C. Eck, and Danette Newton

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Retrospective study of posterior cervical fusions with rhBMP-2, Scott D. Hodges, Jason C. Eck, and Danette Newton

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Patient Flow in Peri-Operative Services: Analysis of Factors that Impact OR Turn Over Time, Shubjeet Kaur, Shimul A. Shah, John J. Wixted, Costin Catalin Negroiu, and Stephen O. Heard

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An evidence-based medicine process to determine outcomes after cervical spine trauma: what surgeons should be telling their patients, Peter Lewkonia, Christian P. DiPaola, Rowan Schouten, Vanessa Noonan, Marcel Dvorak, and Charles G. Fisher

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Intraspinal penetrating stab injury to the middle thoracic spinal cord with no neurologic deficit, Xinning Li, Emily J. Curry, Micah Blais, Richard Ma, and Arno S. Sungarian

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pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute, Xinning Li, Jianwen Xu, Tera M. Filion Potts, David C. Ayers, and Jie Song

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The incidence of C5 palsy after multilevel cervical decompression procedures: a review of 750 consecutive cases, Ahmad Nassr, Jason C. Eck, Ravi K. Ponnappan, Rami R. Zanoun, William F. Donaldson III, and James D. Kang

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Evaluation of sterilization methods following contamination of hamstring autograft during anterior cruciate ligament reconstruction, Matthew J. Plante, Xinning Li, Gail Scully, Michael A. Brown, Brian D. Busconi, and Nicola A. DeAngelis

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Three-part head-splitting proximal humerus fracture through a unicameral bone cyst, John A. Younghein, Mark S. Eskander, Nicola A. DeAngelis, and John J. Wixted

Publications from 2011

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Relationship between anthropometric measurements and hamstring autograft diameter in anterior cruciate ligament reconstruction, Catherine B. Boisvert, Michelle E. Aubin, and Nicola A. DeAngelis

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Mechanics of hip arthroscopy, James R. Boyle, Jason A. Silva, Sean McMillan, and Brian D. Busconi

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Preface. A state-of-the-art overview on the treatment of hip injuries, Brian D. Busconi

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Sports-related Injuries of the Hip, Brian D. Busconi

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Introduction to Arthroscopy of the Hip, Brian D. Busconi and Sean McMillan

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Evolutionary Screening of Collagen-like Peptides That Nucleate Hydroxyapatite Crystals, Woo-Jae Chung, Ki-Young Kwon, Jie Song, and Seung-Wuk Lee

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Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds, Tera M. Filion, Artem Kutikov, and Jie Song

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Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats, Tera M. Filion, Xinning Li, April Mason-Savas, Jaclynn M. Kreider, Steven A. Goldstein, David C. Ayers, and Jie Song

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Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Tera M. Filion and Jie Song

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In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites, Tera M. Filion, Jianwen Xu, Manju L. Prasad, and Jie Song

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Gender and BMI Differences in Physical Activity after Total Knee Replacement, Patricia D. Franklin, Wenjun Li, Wenyun Yang, and David C. Ayers

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Removing a patient from the spine board: is the lift and slide safer than the log roll, MaryBeth Horodyski, Bryan P. Conrad, Gianluca Del Rossi, Christian P. DiPaola, and Glen R. Rechtine II

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Cervical collars are insufficient for immobilizing an unstable cervical spine injury, MaryBeth Horodyski, Christian P. DiPaola, Bryan P. Conrad, and Glen R. Rechtine II

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Soft tissue pathology around the hip, Victor M. Ilizaliturri Jr., Javier Camacho-Galindo, Alberto Nayib Evia Ramirez, Yari Lizette Gonzalez Ibarra, Sean McMillan, and Brian D. Busconi

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A synthesis of best available evidence and expert opinion on outcomes after cervical trauma: what should surgeons be telling their patients, Peter Lewkonia, Christian P. DiPaola, Rowan Schouten, Marcel Dvorak, and Charles G. Fisher

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Athletic pubalgia (sports hernia), Demetrius E. M. Litwin, Erica B. Sneider, Patrick M. McEnaney, and Brian D. Busconi

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Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation, Julie C. Liu, Christopher Joachim Lengner, Tripti Gaur, Yang Lou, Sadiq Hussain, Marci D. Jones, Brent Borodic, Jennifer L. Colby, Heather Anne Steinman, Andre J. Van Wijnen, Janet L. Stein, Stephen N. Jones, Gary S. Stein, and Jane B. Lian

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Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2, Pingsheng Liu, Jonathan Smits, David C. Ayers, and Jie Song

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Entrapped periosteum preventing reduction of a Salter-Harris II distal tibial fracture in an adolescent patient. MRI and intra-operative findings, Xinning Li, Michelle E. Aubin, Emily J. Curry, and Errol S. Mortimer

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Pseudoaneurysm of the profunda femoris artery following a long anterograde intramedullary nail for an unstable intertrochanteric hip fracture: A case report and review of the literature, Xinning Li, Patricia D. Luckeroth, Emily J. Curry, Mohammad H. Eslami, and Walter J. Leclair

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Muscle Injuries and Avulsions, William Morrison, Brian D. Busconi, Sean McMillan, Kristen McClure, Amy Austin, and Rob Fredericks

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Femoral Acetabular Impingement (Cam and Pincer), William Morrison, John P. Salvo Jr., Brian D. Busconi, and Roxanne Wallace

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Labral Tears, Ligament Teres Injury, and Chondral Injury, William Morrison, John P. Salvo Jr., Brian D. Busconi, and Roxanne Wallace

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Synovial Disorders, William Morrison, John P. Salvo Jr., Brian D. Busconi, Roxanne Wallace, and Sean McMillan

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Arthritis, William Morrison, John P. Salvo Jr., Sean McMillan, and Brian D. Busconi

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Open Reduction and Internal Fixation of Intra-Articular Scapular Fractures, Brett D. Owens, Joanna G. Branstetter, and Thomas P. Goss

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Open Reduction and Internal Fixation of Non-Articular Scapular Fractures, Brett D. Owens and Thomas P. Goss

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Radiology, Ketan Patel, Roxanne Wallace, and Brian D. Busconi

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Clinical diagnosis of hip pain, Matthew Plante, Roxanne Wallace, and Brian D. Busconi

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Proximal Femur Fractures, Mark D. Price, Brian D. Busconi, and Sean McMillan

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A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement, Milagros C. Rosal, David C. Ayers, Wenjun Li, Carol Oatis, Amy Borg, Hua Zheng, and Patricia D. Franklin

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Cytocompatible poly(ethylene glycol)-co-polycarbonate hydrogels cross-linked by copper-free, strain-promoted click chemistry, Jianwen Xu, Tera M. Filion Potts, Fioleda Prifti, and Jie Song

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A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates), Jianwen Xu, Fioleda Prifti, and Jie Song

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Thermal Responsive Shape Memory Polymers for Biomedical Applications, Jianwen Xu and Jie Song

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Integrating Patient-reported Symptoms in the Arthritis Care Record, Hua Zheng, David C. Ayers, Janel Milner, Wenyun Yang, and Patricia D. Franklin

Publications from 2010

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions, Jacqueline Akech, John J. Wixted, Krystin Bedard, Margaretha Van der Deen, Sadiq Hussain, T. A. Guise, Andre J. Van Wijnen, Janet L. Stein, Lucia R. Languino, Dario C. Altieri, Jitesh Pratap, E. Keller, Gary S. Stein, and Jane B. Lian

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Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults, Virginia G. Briggs, Wenjun Li, Mark S. Kaplan, Mark S. Eskander, and Patricia D. Franklin