c-myc protooncogene polypeptide expression in endometriosis

UMMS Affiliation

Department of Obstetrics and Gynecology



Document Type


Medical Subject Headings

Adult; Endometriosis; Endometrium; Female; Humans; Immunohistochemistry; Proto-Oncogene Proteins c-myc; Staining and Labeling


Female Urogenital Diseases and Pregnancy Complications | Obstetrics and Gynecology


The c-myc protooncogene and its polypeptide product are important regulators of cell proliferation and differentiation, and ovarian steroids are believed to stimulate growth of various uterine cell types through altered expression of the c-myc gene. To determine whether c-myc expression may also be involved in the growth and development of endometriosis, we assessed c-myc expression in eutopic and ectopic endometrial tissue obtained from women undergoing surgery for endometriosis. Immunocytochemistry using a monoclonal antibody to the c-myc protein demonstrated positive staining of glandular and stromal cell nuclei, and cytoplasmic staining of glandular but not stromal cells in both eutopic and ectopic endometrium. These findings suggest that c-myc expression may be an important regulator of cell proliferation in endometriotic tissue.


Citation: Am J Obstet Gynecol. 1991 Apr;164(4):1031-6; discussion 1036-7.

At the time of publication, Julia Johnson was not yet affiliated with the University of Massachusetts Medical School.

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