Title

Key concepts in management of vulvar cancer

UMMS Affiliation

Department of Obstetrics and Gynecology

Date

10-1-2014

Document Type

Article

Medical Subject Headings

Female; Humans; Papillomaviridae; Papillomavirus Infections; Risk Factors; Vulvar Neoplasms

Disciplines

Female Urogenital Diseases and Pregnancy Complications | Neoplasms | Obstetrics and Gynecology | Oncology | Women's Health

Abstract

Vulvar carcinoma is an uncommon tumor that is seen most often in older women. Subtle symptoms such as pruritus should prompt examination and targeted biopsy in all women as this disease can be successfully treated even in elderly, frail individuals. Vulvar cancer has a bimodal age distribution and is seen in both young and older women with risk factors including human papillomavirus (HPV) infection, smoking, and vulvar skin diseases (i.e., lichen sclerosus). This cancer is staged surgically, with an update in 2009 incorporating prognostic factors. The treatment of vulvar carcinoma has evolved to include more conservative surgical techniques that provide improved cure rates with emphasis on minimizing morbidity. Advanced and metastatic lesions are now treated with chemoradiation which produces substantial cure rates with decreased morbidity. Promising areas of research in vulvar cancer include refinement of sentinel lymph node biopsy, prevention of lymphedema, and preservation of sexual function following treatment.

Rights and Permissions

Citation: Best Pract Res Clin Obstet Gynaecol. 2014 Oct;28(7):959-66. doi: 10.1016/j.bpobgyn.2014.07.001. Epub 2014 Jul 17. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

HPV infection, chemoradiation, sentinel node, vulvar carcinoma, vulvar intraepithelial neoplasia

PubMed ID

25151473