Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2011

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Low Level Bacterial Endotoxin Activates Two Distinct Signaling Pathways in Human peripheral blood mononuclear cells, Andra L. Blomkalns, Lynn L. Stoll, Wassim Shaheen, Sara A. Romig-Martin, Eric W. Dickson, Neal L. Weintraub, and Gerene M. Denning

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A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey

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Adherence with tobramycin inhaled solution and health care utilization, Becky A. Briesacher, Alexandra L. Quittner, Lisa Saiman, Patricia Sacco, Hassan Fouayzi, and Lynne M. Quittell

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Mechanism and regulation of nucleocytoplasmic trafficking of smad, Xiaochu Chen and Lan Xu

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Pelvic inflammatory disease, Thomas L. Cherpes, Peter A. Rice, and Richard L. Sweet

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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation, YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, and Francis Ka-Ming Chan

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A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity, Ryan G. Christensen, Ankit Gupta, Zheng Zuo, Lawrence A. Schriefer, Scot A. Wolfe, and Gary D. Stormo

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Design and methods for a randomized clinical trial comparing three outreach efforts to improve screening mammography adherence, Mary E. Costanza, Roger S. Luckmann, Mary Jo White, Milagros C. Rosal, Caroline Cranos, George W. Reed, Robin E. Clark, Susan Sama, and Robert A. Yood

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Assessment of health sciences and science and technology librarian e-science educational needs to develop an e-science web portal for librarians, Andrew Creamer, Myrna E. Morales, Javier Crespo, Donna Kafel, and Elaine Russo Martin

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Using a structural and logics systems approach to infer bHLH-DNA binding specificity determinants, Federico De Masi, Christian A. Grove, Anastasia Vedenko, Andreu Alibés, Stephen S. Gisselbrecht, Luis Serrano, Martha L. Bulyk, and Albertha J. M. Walhout

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TRAIL and DcR1 expressions are differentially regulated in the pancreatic islets of STZ- versus CY-applied NOD mice, Ercument Dirice, Sevin Kahraman, Gulsum Ozlem Elpek, Cigdem Aydin, Mustafa Kemal Balci, Abdulkadir Omer, Salih Sanlioglue, and Ahter Dilsad Sanlioglue

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Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand, Timothy P. Endy, Kathryn B. Anderson, Ananda Nisalak, In-Kyu Yoon, Sharone Green, Alan L. Rothman, Stephen J. Thomas, Richard G. Jarman, Daniel H. Libraty, and Robert V. Gibbons

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Does Global Health Funding Respond to Recipients’ Needs? Comparing Public and Private Donors’ Allocations in 2005–2007, Daniel E. Esser and Kara Keating Bench

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An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus, Xiaofei E., Mary Theresa Pickering, Michelle E. Debatis, Jonathan Patrick Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, and Timothy F. Kowalik

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From synapse to nucleus and back again--communication over distance within neurons, Mike Fainzilber, Vivian Budnik, Rosalind A. Segal, and Michael R. Kreutz

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Making enhancers from spare parts of the genome, David Fedman, Xianjun Dong, and Boris Lenhard

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Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Tera M. Filion and Jie Song

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Dosing strategies for lithium monotherapy in children and adolescents with bipolar I disorder, Robert L. Findling, Vivian Kafantaris, Mani Pavuluri, Nora K. McNamara, Jon McClellan, Jean A. Frazier, Linmarie Sikich, Robert Kowatch, Jacqui Lingler, Jon Faber, Brieana M. Rowles, Traci E. Clemons, and Perdita Taylor-Zapata

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Improved Responsiveness and Reduced Sample Size Requirements of PROMIS Physical Function Scales with Item Response Theory, James F. Fries, Eswar Krishnan, Matthias S. F. Rose, Bharathi Lingala, and Bonnie Bruce

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Conversion of tumors into autologous vaccines by intratumoral injection of alpha-Gal glycolipids that induce anti-Gal/alpha-Gal epitope interaction, Uri Galili

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Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland, Hira Lal Goel, Donggoo Bae, Bryan M. Pursell, Lindsey M. Gouvin, Shaolei Lu, and Arthur M. Mercurio

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High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism, Jennifer E. Griffin, Jeffrey D. Gawronski, Michael A. Dejesus, Thomas R. Ioerger, Brian J. Akerley, and Christopher M. Sassetti

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Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases, Ankit Gupta, Xiangdong Meng, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe

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Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements, Sneha Gupta and Dannel McCollum

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NSAIDs and atrial fibrillation, Jerry H. Gurwitz

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Interactions between naive and infected macrophages reduce Mycobacterium tuberculosis viability, Michelle L. Hartman and Hardy Kornfeld

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TIEG1/KLF10 Modulates Runx2 Expression and Activity in Osteoblasts, John R. Hawse, Muzaffer Cicek, Sarah B. Grygo, Elizabeth S. Bruinsma, Nalini M. Rajamannan, Andre J. Van Wijnen, Jane B. Lian, Gary S. Stein, Merry Jo Oursler, Malayannan Subramaniam, and Thomas C. Spelsberg

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Acetaminophen-cysteine adducts during therapeutic dosing and following overdose, Kennon J. Heard, Jody L. Green, Laura P. James, Bryan S. Judge, Liza Zolot, Sean Hyun Rhyee, and Richard C. Dart

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{beta}3GnT2 Maintains Adenylyl Cyclase-3 Signaling and Axon Guidance Molecule Expression in the Olfactory Epithelium, Timothy R. Henion, Ashley A. Faden, Thomas K. Knott, and Gerald A. Schwarting

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Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study, Susan S. Huang, Rupak Datta, Sheryl L. Rifas-Shiman, Ken P. Kleinman, Hilary Placzek, Julie Lankiewicz, and Richard Platt

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Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009, Olivier Humblet, Oleg Sergeyev, Larisa Altshul, Susan A. Korrick, Paige L. Williams, Claude Emond, Linda S. Birnbaum, Jane S. Burns, Mary M. Lee, Boris Revich, Andrey Shelepchikov, Denis Feshin, and Russ Hauser

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Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma, Ma. Reina D. Improgo, Christopher W. Johnson, Andrew R. Tapper, and Paul D. Gardner

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Scaling behavior of human locomotor activity amplitude: association with bipolar disorder, Premananda Indic, Paola Salvatore, Carlo Maggini, Stefano Ghidini, Gabriella Ferraro, Ross J. Baldessarini, and Greg Murray

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Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases, Nicholas M. Kanaan, Gerardo A. Morfini, Nichole E. Lapointe, Gustavo F. Pigino, Kristina R. Patterson, Yuyu Song, Athena Andreadis, Yifan Fu, Scott T. Brady, and Lester I. Binder

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MicroRNA biogenesis and regulation of bone remodeling, Kristina Kapinas and Anne M. Delany

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Genome surveyor 2.0: cis-regulatory analysis in Drosophila, Majid Kazemian, Michael H. Brodsky, and Saurabh Sinha

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The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain, Jae-Sung Kim, Jeffrey S. Kroin, Xin Li, Howard S. An, Asokumar Buvanendran, Dongyao Yan, Kenneth J. Tuman, Andre J. Van Wijnen, Di Chen, and Hee-Jeong Im

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Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

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Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1, Alexei V. Korennykh, Pascal F. Egea, Andrei A. Korostelev, Janet Finer-Moore, Robert M. Stroud, Chao Zhang, Kevan M. Shokat, and Peter Walter

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Structural and functional basis for RNA cleavage by Ire1, Alexei V. Korennykh, Andrei A. Korostelev, Pascal F. Egea, Janet Finer-Moore, Robert M. Stroud, Chao Zhang, Kevan M. Shokat, and Peter Walter

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Dioxin Exposure and Age of Pubertal Onset Among Russian Boys, Susan A. Korrick, Mary M. Lee, Paige L. Williams, Oleg Sergeyev, Jane S. Burns, Donald G. Patterson, Wayman E. Turner, Larry L. Needham, Larisa Altshul, Boris Revich, and Russ Hauser

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Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response, Miroslav Koulnis, Ying Liu, Kelly N. Hallstrom, and Merav Socolovsky

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Repeated cleavage failure does not establish centrosome amplification in untransformed human cells, Anna Krzywicka-Racka and Greenfield Sluder

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Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest, Suparna Laha, Shankar Das, Sujata Hajra, Kaustuv Sanyal, and Pratima Sinha

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ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons, Jin-A Lee, Lei Liu, Robyn Javier, Anatol C. Kreitzer, Celine Delaloy, and Fen-Biao Gao

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Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages, Jinhee Lee, Teresa Repasy, Kadamba Papavinasasundaram, Christopher M. Sassetti, and Hardy Kornfeld

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An Expressed Sequence Tag collection from the male antennae of the Noctuid moth Spodoptera littoralis: a resource for olfactory and pheromone detection research, Fabrice Legeai, Sebastien Malpel, Nicolas Montagne, Christelle Monsempes, Francois Cousserans, Christine Merlin, Marie-Christine Francois, Martine Maibeche-Coisne, Frederick Gavory, Julie Poulain, and Emmanuelle Jacquin-Joly

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Uncovering intrinsic connectional architecture of functional networks in awake rat brain, Zhifeng Liang, Jean A. King, and Nanyin Zhang

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Maternal exposure to angiotensin converting enzyme inhibitors in the first trimester and risk of malformations in offspring: a retrospective cohort study, De-Kun Li, Chunmei Yang, Susan E. Andrade, Venessa Tavares, and Jeannette R. Ferber

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Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection, Jun Li, Yaping Han, Ke Jin, Yufeng Wan, Shixia Wang, Bo Liu, Yuan Liu, Shan Lu, and Zuhu Huang

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The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty

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A new approach to monitoring dengue activity, Lawrence C. Madoff, David N. Fisman, and Taha Kass-Hout

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The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4, Chandrashekara Mallappa, Yu-Jie Hu, Priscilla Shamulailatpam, Sookil Tae, Said Sif, and Anthony N. Imbalzano

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No immune responses by the expression of the yeast Ndi1 protein in rats, Mathieu Marella, Byoung Boo Seo, Terence R. Flotte, Akemi Matsuno-Yagi, and Takao Yagi

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Cytotoxic CD4 T cells in antiviral immunity, Nikki B. Marshall and Susan L. Swain

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A User's Guide to the Encyclopedia of DNA Elements (ENCODE), Richard M. Meyers, ENCODE Project Consortium, Job Dekker, Bryan R. Lajoie, Amartya Sanyal, Zhiping Weng, Troy W. Whitfield, and Jie Wang

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Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance, Nathan Moore and Stephen Lyle

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The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing, Luis G. Morello, Patricia P. Coltri, Alexandre J.C. Quaresma, Fernando M. Simabuco, Tereza C.L. Sila, Guramrit Singh, Jeffrey A. Nickerson, Carla C. Oliveira, Melissa J. Moore, and Nilson I. T. Zanchin

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PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum

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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian

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Pseudohypoparathyroidism in Children, Benjamin U. Nwosu

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Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes, Joel M. O'Bryan, James A. Potts, Herbert L. Bonkovsky, Anuja Mathew, and Alan L. Rothman

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Inhibition of TLR8- and TLR4-induced Type I IFN Induction by Alcohol is Different from its effects on inflammatory cytokine production in monocytes, Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure, David Park, David D. McManus, Chad E. Darling, Jordan H. Goldberg, Joel M. Gore, Darleen M. Lessard, and Robert J. Goldberg

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Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract, Dane Parker, Francis J. Martin, Grace Soong, Bryan S. Harfenist, Jorge L. Aguilar, Adam J. Ratner, Katherine A. Fitzgerald, Christian Schindler, and Alice Prince

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Functional analysis of retinitis pigmentosa 2 (RP2) protein reveals variable pathogenic potential of disease-associated missense variants, Suresh B. Patil, Toby W. Hurd, Amiya K. Gosh, Carlos A. Murga-Zamalloa, and Hemant Khanna

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Accelerating protein docking in ZDOCK using an advanced 3D convolution library, Brian G. Pierce, Yichiro Hourai, and Zhiping Weng

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Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff

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Recombination Phenotypes of Escherichia Coli greA Mutants, Anthony R. Poteete

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A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice, Linghua Qiu, Jaime A. Rivera-Perez, and Zuoshang Xu

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Patterns and mechanisms of ancestral histone protein inheritance in budding yeast, Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J. Rando, and Fred van Leeuwen

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Genome Sequence of an Australian Kangaroo, Macropus Eugenii, Provides Insight into the Evolution of Mammalian Reproduction and Development, Marilyn B. Renfree, Anthony T. Papenfuss, Janine E. Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D. Waters, Elizabeth A. Pharo, Geoff Shaw, Emily S. W. Wong, Christophe M. Lefevre, Kevin R. Nicholas, Yoko Kuroki, Matthew J. Wakefield, Kyall R. Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W. Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R. Short, Hannah V. Siddle, Stephen R. Frankenberg, Keng Yih Chew, Brandon R. Menzies, Jessica M. Stringer, Shunsuke Suzuki, Timothy A. Hore, Margaret L. Delbridge, Amir Mohammadi, Nanette Y. Schneider, Yanqiu Hu, William O'Hara, Shafagh Al Nadaf, Chen Wu, Zhi-Ping Feng, Benjamin G. Cocks, Jianghui Wang, Paul Flicek, Stephen M. J. Searle, Susan Fairley, Kathryn Beal, Javier Herrero, Dawn M. Carone, Yutaka Suzuki, Sumio Sugano, Atsushi Toyoda, Yoshiyuki Sakaki, Shinji Kondo, Yuichiro Nishida, Shoji Tatsumoto, Ion Mandiou, Arthur Hsu, Kaighin A. McColl, Benjamin Lansdell, George Weinstock, Elizabeth Kuczek, Annette McGrath, Peter Wilson, Artem Men, Mehlika Hazar-Rethinam, Allison Hall, John Davis, David Wood, Sarah Williams, Yogi Sundaravadanam, Donna M. Muzny, Shalini N. Jhangiani, Lora R. Lewis, Margaret B. Morgan, Geoffrey O. Okwuonu, San Juana Ruiz, Jireh Santibanez, Lynne Nazareth, Andrew Cree, Gerald Fowler, Christie L. Kovar, Huyen H. Dinh, Vandita Joshi, Chyn Jing, Fremiet Lara, Rebecca Thornton, Lei Chen, Jixin Deng, Yue Liu, Joshua Y. Shen, Xing-Zhi Song, Janette Edson, Carmen Troon, Daniel Thomas, Amber Stephens, Lankesha Yapa, Tanya Levchenko, Richard A. Gibbs, Desmond W. Cooper, Terence P. Speed, Asao Fujiyama, Jennifer A.M. Graves, Rachel J. O'Neill, Andrew J. Pask, Susan M. Forrest, and Kim C. Worley

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement, Milagros C. Rosal, David C. Ayers, Wenjun Li, Carol Oatis, Amy Borg, Hua Zheng, and Patricia D. Franklin

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Religion and Healthy Lifestyle Behaviors Among Postmenopausal Women: the Women's Health Initiative, Elena Salmoirago Blotcher, George Fitchett, Judith K. Ockene, Eliezer Schnall, Sybil L. Crawford, Iris Granek, JoAnne Manson, Ira S. Ockene, Mary Jo O'Sullivan, Linda Powell, and Stephen Rapp

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A 5'-uridine Amplifies miRNA/miRNA* Asymmetry in Drosophila by Promoting RNA-induced Silencing Complex Formation, Herve Seitz, Jogender S. Tushir, and Phillip D. Zamore

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MicroRNA Expression Data Reveals a Signature of Kidney Damage following Ischemia Reperfusion Injury, Michael D. Shapiro, Jessamyn Bagley, Jeff Latz, Jonathan G. Godwin, Xupeng Ge, Stefan G. Tullius, and John Iacomini

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Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure, Mark E. Sharkey, Dunja Z. Babic, Thomas C. Greenough, Roy Gulick, Daniel R. Kuritzkes, and Mario Stevenson

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Innate immune sensing of DNA, Shrutie Sharma and Katherine A. Fitzgerald

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On detecting selective sweeps using single genomes, Priyanka Sinha, Aslihan Dincer, Daniel Virgil, Guang Xu, Yu-Ping Poh, and Jeffrey D. Jensen

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Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW), Ethel S. Siris, Stephen H. Gehlbach, J. D. Adachi, S. Boonen, R. D. Chapurlat, J. E. Compston, C. Cooper, P. Delmas, A. Diez-Perez, Fred H. Hooven, Andrea Z. LaCroix, J. C. Netelenbos, J. Pfeilschifter, M. Rossini, C. Roux, Kenneth G. Saag, P. Sambrook, S. Silverman, N. B. Watts, Allison Wyman, and S. L. Greenspan

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Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population, Guido Stadler; Jennifer Cj Chen; Kathryn Wagner; Jerome D. Robin; Jerry W. Shay; Charles P. Emerson, Jr.; and Woodring E. Wright

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Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection, Barbara S. Stewart, Valerie L. Demarest, Susan J. Wong, Sharone Green, and Kristen A. Bernard

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Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells, Con Sullivan, Yaoyu Chen, Yi Shan, Yiguo Hu, Cong Peng, Haojian Zhang, Linghong Kong, and Shaoguang Li

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Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex, Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua Julie Zhu, Inmaculada M. Barrasa, Melissa M. Harrison, Robert H. Horvitz, Albertha J. M. Walhout, and Kirsten A. Hagstrom

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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans, Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A. Hall, Katherine A. Fitzgerald, and Amy G. Hise

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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity, Steven F. Trueman, Elisabet C. Mandon, and Reid Gilmore

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The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear, Cristina M. Velazquez-Marrero, Patricia M. Wynne, Alexandra Bernardo, Stephanie Palacio, Gilles E. Martin, and Steven N. Treistman

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Characteristics, Practice Patterns, and Outcomes in Patients with Acute Hypertension: European Registry for Studying the Treatment of Acute HyperTension (Euro-STAT), Alain Vuylsteke, Jean-Louis Vincent, Didier Payen de La Garanderie, Frederick A. Anderson Jr., Leigh A. Emery, Allison Wyman, Sophie Rushton-Smith, and Joel M. Gore

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What does biologically meaningful mean? A perspective on gene regulatory network validation, Albertha J. M. Walhout

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Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans, Jennifer P. Wang, Chrono K. Lee, Ali Akalin, Robert W. Finberg, and Stuart M. Levitz

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RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism, Ping Wei, Dongning Pan, Chunxiao Mao, and Yong-Xu Wang

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124, Xia-Lian Xu, Ruiting Zong, Zhaodong Li, Md Helal Uddin Biswas, Zhe Fang, David L. Nelson, and Fen-Biao Gao

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Fibroblast Growth Factor Receptor 1 is Principally Responsible for Fibroblast Growth factor 2-induced catabolic activities in human articular chondrocytes, Gongyao Yan, Di Chen, Simon M. Cool, Andre J. Van Wijnen, Katalin Mikecz, Gillian Murphy, and Hee-Jeong Im

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Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50, Yong Yang, Deborah A. Cochran, Mary D. Gargano, Iryna King, Nayef K. Samhat, Benjain P. Burger, Katherine R. Sabourin, Yuqing Hou, Junya Awata, David A.D. Parry, Wallace F. Marshall, George B. Witman, and Xiangyi Lu

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DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road, Kelvin Yen, Sri Devi Narasimhan, and Heidi A. Tissenbaum

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Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors, Ikuko Yonamine, Takeshi Bamba, Niraj K. Nirala, Nahid Jesmin, Teresa Kosakowska-Cholody, Kunio Nagashima, Eiichiro Fukasaki, Jairaj K. Acharya, and Usha Acharya

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CDase is a pan-ceramidase in Drosophila, Changqing Yuan, Raghavendra Pralhada Rao, Nahid Jesmin, Takeshi Bamba, Kunio Nagashima, Alberto Pascual, Thomas Preat, Eiichiro Fukusaki, Usha Acharya, and Jairaj K. Acharya

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Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes, Elizabeth A. Yu and David R. Weaver