Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2011

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Pseudohypoparathyroidism in Children, Benjamin U. Nwosu

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Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes, Joel M. O'Bryan, James A. Potts, Herbert L. Bonkovsky, Anuja Mathew, and Alan L. Rothman

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Inhibition of TLR8- and TLR4-induced Type I IFN Induction by Alcohol is Different from its effects on inflammatory cytokine production in monocytes, Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure, David Park, David D. McManus, Chad E. Darling, Jordan H. Goldberg, Joel M. Gore, Darleen M. Lessard, and Robert J. Goldberg

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Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract, Dane Parker, Francis J. Martin, Grace Soong, Bryan S. Harfenist, Jorge L. Aguilar, Adam J. Ratner, Katherine A. Fitzgerald, Christian Schindler, and Alice Prince

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Functional analysis of retinitis pigmentosa 2 (RP2) protein reveals variable pathogenic potential of disease-associated missense variants, Suresh B. Patil, Toby W. Hurd, Amiya K. Gosh, Carlos A. Murga-Zamalloa, and Hemant Khanna

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Accelerating protein docking in ZDOCK using an advanced 3D convolution library, Brian G. Pierce, Yichiro Hourai, and Zhiping Weng

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Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff

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Recombination Phenotypes of Escherichia Coli greA Mutants, Anthony R. Poteete

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A Non-Specific Effect Associated with Conditional Transgene Expression Based on Cre-loxP Strategy in Mice, Linghua Qiu, Jaime A. Rivera-Perez, and Zuoshang Xu

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Patterns and mechanisms of ancestral histone protein inheritance in budding yeast, Marta Radman-Livaja, Kitty F. Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J. Rando, and Fred van Leeuwen

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Genome Sequence of an Australian Kangaroo, Macropus Eugenii, Provides Insight into the Evolution of Mammalian Reproduction and Development, Marilyn B. Renfree, Anthony T. Papenfuss, Janine E. Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D. Waters, Elizabeth A. Pharo, Geoff Shaw, Emily S. W. Wong, Christophe M. Lefevre, Kevin R. Nicholas, Yoko Kuroki, Matthew J. Wakefield, Kyall R. Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W. Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R. Short, Hannah V. Siddle, Stephen R. Frankenberg, Keng Yih Chew, Brandon R. Menzies, Jessica M. Stringer, Shunsuke Suzuki, Timothy A. Hore, Margaret L. Delbridge, Amir Mohammadi, Nanette Y. Schneider, Yanqiu Hu, William O'Hara, Shafagh Al Nadaf, Chen Wu, Zhi-Ping Feng, Benjamin G. Cocks, Jianghui Wang, Paul Flicek, Stephen M. J. Searle, Susan Fairley, Kathryn Beal, Javier Herrero, Dawn M. Carone, Yutaka Suzuki, Sumio Sugano, Atsushi Toyoda, Yoshiyuki Sakaki, Shinji Kondo, Yuichiro Nishida, Shoji Tatsumoto, Ion Mandiou, Arthur Hsu, Kaighin A. McColl, Benjamin Lansdell, George Weinstock, Elizabeth Kuczek, Annette McGrath, Peter Wilson, Artem Men, Mehlika Hazar-Rethinam, Allison Hall, John Davis, David Wood, Sarah Williams, Yogi Sundaravadanam, Donna M. Muzny, Shalini N. Jhangiani, Lora R. Lewis, Margaret B. Morgan, Geoffrey O. Okwuonu, San Juana Ruiz, Jireh Santibanez, Lynne Nazareth, Andrew Cree, Gerald Fowler, Christie L. Kovar, Huyen H. Dinh, Vandita Joshi, Chyn Jing, Fremiet Lara, Rebecca Thornton, Lei Chen, Jixin Deng, Yue Liu, Joshua Y. Shen, Xing-Zhi Song, Janette Edson, Carmen Troon, Daniel Thomas, Amber Stephens, Lankesha Yapa, Tanya Levchenko, Richard A. Gibbs, Desmond W. Cooper, Terence P. Speed, Asao Fujiyama, Jennifer A.M. Graves, Rachel J. O'Neill, Andrew J. Pask, Susan M. Forrest, and Kim C. Worley

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Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants, Nicholas Renzette, Bornali Bhattacharjee, Jeffrey D. Jensen, Laura L. Gibson, and Timothy F. Kowalik

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A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement, Milagros C. Rosal, David C. Ayers, Wenjun Li, Carol Oatis, Amy Borg, Hua Zheng, and Patricia D. Franklin

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Religion and Healthy Lifestyle Behaviors Among Postmenopausal Women: the Women's Health Initiative, Elena Salmoirago Blotcher, George Fitchett, Judith K. Ockene, Eliezer Schnall, Sybil L. Crawford, Iris Granek, JoAnne Manson, Ira S. Ockene, Mary Jo O'Sullivan, Linda Powell, and Stephen Rapp

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A 5'-uridine Amplifies miRNA/miRNA* Asymmetry in Drosophila by Promoting RNA-induced Silencing Complex Formation, Herve Seitz, Jogender S. Tushir, and Phillip D. Zamore

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MicroRNA Expression Data Reveals a Signature of Kidney Damage following Ischemia Reperfusion Injury, Michael D. Shapiro, Jessamyn Bagley, Jeff Latz, Jonathan G. Godwin, Xupeng Ge, Stefan G. Tullius, and John Iacomini

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Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure, Mark E. Sharkey, Dunja Z. Babic, Thomas C. Greenough, Roy Gulick, Daniel R. Kuritzkes, and Mario Stevenson

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Innate immune sensing of DNA, Shrutie Sharma and Katherine A. Fitzgerald

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Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW), Ethel S. Siris, Stephen H. Gehlbach, J. D. Adachi, S. Boonen, R. D. Chapurlat, J. E. Compston, C. Cooper, P. Delmas, A. Diez-Perez, Fred H. Hooven, Andrea Z. LaCroix, J. C. Netelenbos, J. Pfeilschifter, M. Rossini, C. Roux, Kenneth G. Saag, P. Sambrook, S. Silverman, N. B. Watts, Alison Wyman, and S. L. Greenspan

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Persistence of virus-specific immune responses in the central nervous system of mice after West Nile virus infection, Barbara S. Stewart, Valerie L. Demarest, Susan J. Wong, Sharone Green, and Kristen A. Bernard

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Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells, Con Sullivan, Yaoyu Chen, Yi Shan, Yiguo Hu, Cong Peng, Haojian Zhang, Linghong Kong, and Shaoguang Li

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Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex, Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua Julie Zhu, Inmaculada M. Barrasa, Melissa M. Harrison, Robert H. Horvitz, Albertha J. M. Walhout, and Kirsten A. Hagstrom

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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans, Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A. Hall, Katherine A. Fitzgerald, and Amy G. Hise

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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity, Steven F. Trueman, Elisabet C. Mandon, and Reid Gilmore

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The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear, Cristina M. Velazquez-Marrero, Patricia M. Wynne, Alexandra Bernardo, Stephanie Palacio, Gilles E. Martin, and Steven N. Treistman

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Characteristics, Practice Patterns, and Outcomes in Patients with Acute Hypertension: European Registry for Studying the Treatment of Acute HyperTension (Euro-STAT), Alain Vuylsteke, Jean-Louis Vincent, Didier Payen de La Garanderie, Frederick A. Anderson Jr., Leigh A. Emery, Alison Wyman, Sophie Rushton-Smith, and Joel M. Gore

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What does biologically meaningful mean? A perspective on gene regulatory network validation, Albertha J. M. Walhout

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Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans, Jennifer P. Wang, Chrono K. Lee, Ali Akalin, Robert W. Finberg, and Stuart M. Levitz

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RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism, Ping Wei, Dongning Pan, Chunxiao Mao, and Yong-Xu Wang

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression, Jun Xie, Qing Xie, Hongwei Zhang, Stefan L. Ameres, Jui-Hung Hung, Qin Su, Ran He, Xin Mu, Seemin Seher Ahmed, Soyeon Park, Hiroki Kato, Chengjian Li, Christian Mueller, Craig C. Mello, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao

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FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124, Xia-Lian Xu, Ruiting Zong, Zhaodong Li, Md Helal Uddin Biswas, Zhe Fang, David L. Nelson, and Fen-Biao Gao

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Fibroblast Growth Factor Receptor 1 is Principally Responsible for Fibroblast Growth factor 2-induced catabolic activities in human articular chondrocytes, Gongyao Yan, Di Chen, Simon M. Cool, Andre J. Van Wijnen, Katalin Mikecz, Gillian Murphy, and Hee-Jeong Im

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Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50, Yong Yang, Deborah A. Cochran, Mary D. Gargano, Iryna King, Nayef K. Samhat, Benjain P. Burger, Katherine R. Sabourin, Yuqing Hou, Junya Awata, David A.D. Parry, Wallace F. Marshall, George B. Witman, and Xiangyi Lu

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DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road, Kelvin Yen, Sri Devi Narasimhan, and Heidi A. Tissenbaum

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Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors, Ikuko Yonamine, Takeshi Bamba, Niraj K. Nirala, Nahid Jesmin, Teresa Kosakowska-Cholody, Kunio Nagashima, Eiichiro Fukasaki, Jairaj K. Acharya, and Usha Acharya

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CDase is a pan-ceramidase in Drosophila, Changqing Yuan, Raghavendra Pralhada Rao, Nahid Jesmin, Takeshi Bamba, Kunio Nagashima, Alberto Pascual, Thomas Preat, Eiichiro Fukusaki, Usha Acharya, and Jairaj K. Acharya

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Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes, Elizabeth A. Yu and David R. Weaver

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MicroRNA-9: functional evolution of a conserved small regulatory RNA, Yeliz Yuva-Aydemir, Alfred Simkin, Eduardo Gascon, and Fen-Biao Gao

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Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells, Nancy R. Zearfoss, Carina C. Clingman, Brian M. Farley, Lisa M. McCoig, and Sean P. Ryder

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Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish, Cong Zhu, Tom Smith, Joseph C. McNulty, Amy L. Rayla, Abirami Lakshmanan, Arndt F. Siekmann, Matthew Buffardi, Xiangdong Meng, Jimann Shin, Arun Padmanabhan, Daniel Cifuentes, Antonio J. Giraldez, A. Thomas Look, Jonathan A. Epstein, Nathan D. Lawson, and Scot A. Wolfe

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FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system, Lihua Julie Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo Selase Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, and Michael H. Brodsky

Publications from 2010

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Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women, Jonathan D. Adachi, Silvano Adami, Stephen H. Gehlbach, Frederick A. Anderson Jr., Steven Boonen, Roland D. Chapurlat, Juliet E. Compston, Cyrus Cooper, Pierre Delmas, Adolfo Diez-Perez, Susan L. Greenspan, Frederick H. Hooven, Andrea Z. LaCroix, Robert Lindsay, J. Coen Netelenbos, Olivia Wu, Johannes Pfeilschifter, Christian Roux, Kenneth G. Saag, Phillip Sambrook, Stuart Silverman, Ethel S. Siris, Grigor Nika, Nelson B. Watts, and GLOW Investigators

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In the tradition of science: an interview with Victor Ambros, Victor R. Ambros

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Riding in silence: a little snowboarding, a lot of small RNAs, Stefan L. Ameres and Ryuya Fukunaga

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Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network., H. Efsun Arda, Stefan Taubert, Lesley T. MacNeil, Colin C. Conine, Ben Tsuda, Marc Van Gilst, Reynaldo Sequerra, Lynn Doucette-Stamm, Keith R. Yamamoto, and Albertha J. M. Walhout

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Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study, Amolo S. Asito, Erwan Piriou, Peter Sumba Odada, Nancy Fiore, Jaap M. Middeldorp, Carole Long, Sheetij Dutta, David E. Lanar, Walter G.Z.O. Jura, Collins Ouma, Juliana A. Otieno, Ann M. Moormann, and Rosemary Rochford

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A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans, Belinda Barbagallo, Hilary A. Prescott, Patrick Boyle, Jason Climer, and Michael M. Francis

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Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat

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Welcome to silence, David C. Baulcombe and Phillip D. Zamore

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Cebus cf. apella exhibits rapid acquisition of complex stimulus relations and emergent performance by exclusion, Ana Leda F. Brino, Ana Paula Bemerguy Assumpcao, Rodolfo da Silva Campos, Olavo F. Galvao, and William J. McIlvane

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Role of JNK in a Trp53-dependent mouse model of breast cancer, Cristina Arrigo Cellurale, Claire R. Weston, Judith Reilly, David S. Garlick, D. Joseph Jerry, Hayla Karen Sluss, and Roger J. Davis

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A simple method for improving the specificity of anti-methyl histone antibodies, Caroline M. Connor, Iris Cheung, Andrew Simon, Mira Jakovcevski, Zhiping Weng, and Schahram Akbarian

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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content, Branch Craige, Che-Chia Tsao, Dennis R. Diener, Yuqing Hou, Karl-Ferdinand Lechtreck, Joel L. Rosenbaum, and George B. Witman

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The prevalence of obesity in children with autism: a secondary data analysis using nationally representative data from the National Survey of Children's Health, Carol Curtin, Sarah E. Anderson, Aviva Must, and Linda G. Bandini

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The role of Drosophila Lamin C in muscle function and gene expression, George Dialynas, Sean D. Speese, Vivian Budnik, Pamela K. Geyer, and Lori L. Wallrath

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Thwarting Science by Protecting the Received Wisdom on Tobacco Addiction from the Scientific Method, Joseph R. DiFranza

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Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p, Shuyun Dong, Allan Jacobson, and Feng He

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Vulnerability-based spatial sampling stratification for the National Children's Study, Worcester County, Massachusetts: capturing health-relevant environmental and sociodemographic variability, Timothy J. Downs, Yelena Ogneva-Himmelberger, Onesky Aupont, Yangyang Wang, Ann Raj, Paula Zimmerman, Robert Goble, Octavia Taylor, Linda C. Churchill, Celeste A. Lemay, Thomas J. McLaughlin, and Marianne E. Felice

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Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro, Jean-Pierre Etchegaray, Elizabeth A. Yu, Premananda Indic, Robert Dallmann, and David R. Weaver

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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells, Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski, Simin Lu, Kathryn L. Lipson, Rajarshi Ghosh, Emiko Hayashi, Hisamitsu Ishihara, Yoshitomo Oka, M. Alan Permutt, and Fumihiko Urano

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Stress hypERactivation in the beta-cell, Sonya G. Fonseca, Fumihiko Urano, Mark Burcin, and Jesper Gromada

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Context-dependent functions of specific microRNAs in neuronal development, Fen-Biao Gao

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Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene, Nele Gheldof, Emily M. Smith, Tomoko M. Tabuchi, Christoph M. Koch, Ian Dunham, John A. Stamatoyannopoulos, and Job Dekker

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Transcriptional regulation of VEGF-A by the unfolded protein response pathway, Rajarshi Ghosh, Kathryn L. Lipson, Karen E. Sargent, Arthur M. Mercurio, Joan S. Hunt, David Ron, and Fumihiko Urano

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Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors, Jonathan A. R. Gordon, Mohammad Q. Hassan, Sharanjot Saini, Martin A. Montecino, Andre J. Van Wijnen, Gary S. Stein, Janet L. Stein, and Jane B. Lian

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Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein, Nadege Goutagny, Zhaozhao Jiang, Jane Tian, Peggy Parroche, Jeanne Schickli, Brian G. Monks, Nancy Ulbrandt, Hong Ji, Peter A. Kiener, Anthony J. Coyle, and Katherine A. Fitzgerald

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Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage, Thomas C. Greenough, Shalyn C. Campellone, Robin M. Brody, Surbhi Jain, Victor Sanchez-Merino, Mohan Somasundaran, and Katherine Luzuriaga

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Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption, Linzy M. Hendrickson, Rubing Zhao-Shea, Xueyan Pang, Paul D. Gardner, and Andrew R. Tapper

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Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded beta-Glucan Particles, Habin Huang, Gary R. Ostroff, Chrono K. Lee, Charles A. Specht, and Stuart M. Levitz

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Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study, Susan S. Huang, Deborah S. Yokoe, John Stelling, Hilary Placzek, Martin Kulldorff, Ken Kleinman, Thomas F. O'Brien, Michael S. Calderwood, Johanna Vostok, Julie Dunn, and Richard Platt

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Identification of functional modules that correlate with phenotypic difference: the influence of network topology, Jui-Hung Hung, Troy W. Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, and Charles Delisi

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The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues, Jae-Hwan Jeong, Youn-Kwan Jung, Hyo-Jin Kim, Jung-Sook Jin, Hyun-Nam Kim, Sang-Min Kang, Shin-Yoon Kim, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, and Je-Yong Choi

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Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B, Yan Jiang, Mira Jakovcevski, Rahul Bharadwaj, Caroline M. Connor, Frederick Albert Schroeder, Cong L. Lin, Juerg R. Straubhaar, Gilles E. Martin, and Schahram Akbarian

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MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia, Jian Jiao, Lauren D. Herl, Robert V. Farese, and Fen-Biao Gao

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A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells, Agata Jurczyk, Steven C. Pino, Bryan O'Sullivan-Murphy, Martha Addorio, Erich A. Lidstone, Philip diLorio, Kathryn L. Lipson, Clive Standley, Kevin E. Fogarty, Lawrence M. Lifshitz, Fumihiko Urano, John P. Mordes, Dale L. Greiner, Aldo A. Rossini, and Rita Bortell

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CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion, Ming-Chung Kan, Aparna Oruganty-Das, Amalene Cooper-Morgan, Guang Jin, Sharon A. Swanger, Gary J. Bassell, Harvey M. Florman, Klaus van Leyen, and Joel D. Richter

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Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors, Kimberly B. Kegel, Ellen Sapp, Jonathan Alexander, Patrick Reeves, Dorothee Bleckmann, Linsday Sobin, Nicholas Masso, Antonio Valencia, Hyunkyung Jeong, Dimitri Krainc, James Palacino, Daniel Curtis, Rainer Kuhn, Claudia Betschart, Miguel Sena-Esteves, Neil Aronin, Paolo Paganetti, and Marian DiFiglia

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Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection, Jaspreet S. Khurana, Jia Xu, Zhiping Weng, and William E. Theurkauf

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RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast, Tae Soo Kim, Chih Long Liu, Moran Yassour, John Holik, Nir Friedman, Stephen Buratowski, and Oliver J. Rando

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G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke, Rainer Kollmar, Nils Henninger, Christian Urbanek, and Stefan Schwab

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Uric acid promotes an acute inflammatory response to sterile cell death in mice, Hajime Kono, Chun-Jen Chen, Fernando Ontiveros, and Kenneth L. Rock

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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts, Oliver Kumpf, Evangelos J. Giamarellos-Bourboulis, Alexander Koch, Lutz Hamann, Maria Mouktaroudi, Djin-Ye Oh, Eicke Latz, Eva Lorenz, David A. Schwartz, Bart Ferwerda, Christina Routsi, Chryssanthi Skalioti, Bart-Jan Kullberg, Jos W. M. van der Meer, Peter M. Schlag, Mihai G. Netea, Kai Zacharowski, and Ralf R. Schumann

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Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility, David T. Leong, Jitesh Pratap, Barry P. Pereira, Saminathan S. Nathan, Jason R. Dobson, Jane B. Lian, Yoshiaki Ito, Gary S. Stein, Manuel Salto-Tellez, Simon M. Cool, Andre J. Van Wijnen, Joleen Lim, Xuewei Goh, Hui S. Kwok, and P. Mathijs Voorhoeve

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Innate recognition of fungal cell walls, Stuart M. Levitz

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The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement, Lisa A. Lewis, Jutamas Ngampasutadol, Ruth Wallace, Jane E. A. Reid, Ulrich Vogel, and Sanjay Ram

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Acetylation of WRN protein regulates its stability by inhibiting ubiquitination, Kai Li, Rui Wang, Enerlyn M. Lozada, Wei Fan, David K. Orren, and Jianyuan Luo

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Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain, Suewei Lin, Sen-Lin Lai, Hung-Hsiang Yu, Takahiro Chihara, Liqun Luo, and Tzumin Lee

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Medial pelvic migration of the lag screw in a short gamma nail after hip fracture fixation: a case report and review of the literature, Xinning Li, Michael J. Heffernan, Christina Kane, and Walter J. Leclair

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Detecting microRNA activity from gene expression data, Stephen F. Madden, Susan B. Carpenter, Ian B. Jeffery, Harry Bjorkbacka, Katherine A. Fitzgerald, Luke A. J. O'Neill, and Desmond G. Higgins

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Neighborhood socioeconomic deprivation and mortality: NIH-AARP diet and health study, Jacqueline M. Major, Chyke A. Doubeni, Neal D. Freedman, Yikyung Park, Min Lian, Albert R. Hollenbeck, Arthur Schatzkin, Barry I. Graubard, and Rashmi Sinha

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Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function, Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerstrom, Yasuyuki Ohkawa, and Anthony N. Imbalzano

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Response to Neil Rambo's editorial: “E-science and Biomedical Libraries”, Elaine Russo Martin and Donna Kafel

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4, Edel A. McNeela, Aine Burke, Daniel R. Neill, Cathy Baxter, Vitor E. Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M. McLoughlin, Andres Mori, Barry Moran, Katherine A. Fitzgerald, Jurg Tschopp, Virginie Petrilli, Peter W. Andrew, Aras Kadioglu, and Ed C. Lavelle

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NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors, Rabinarayan Mishra, Alex T. Chen, Raymond M. Welsh, and Eva Szomolanyi-Tsuda

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Cortical Vein Thrombosis as a Mimic for Isolated Cortical Subarachnoid Hemorrhage and Transient Ischemic Attack, Jane G. Morris, Marc Fisher, and Raphael A. Carandang

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Integrating one-dimensional and three-dimensional maps of genomes, Natalia Naumova and Job Dekker

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Insertion of tetracysteine motifs into dopamine transporter extracellular domains, Deanna M. Navaroli and Haley E. Melikian

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Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies, Paul R. Odgren, Craig H. Pratt, Carole A. MacKay, April Mason-Savas, Michelle Curtain, Lindsay S. Shopland, Tsutomu Ichicki, John P. Sundberg, and Leah Rae Donahue

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Toll-like receptors in the pathogenesis of alcoholic liver disease, Jan Petrasek, Pranoti Mandrekar, and Gyongyi Szabo