Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2015

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Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes, Shikui Tu, Monica Z. Wu, Jie Wang, Asher D. Cutter, Zhiping Weng, and Julie M. Claycomb

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Development and Validation of the Behavioral Tendencies Questionnaire, Nicholas T. Van Dam, Anna Brown, Tom B. Mole, Jake H. Davis, Willoughby B. Britton, and Judson A. Brewer

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Distinguishing grade I meningioma from higher grade meningiomas without biopsy, John Varlotto, John Flickinger, Martin T. Pavelic, Charles S. Specht, Jonas M. Sheehan, Dana T. Timek, Michael J. Glantz, Steven Sogge, Christopher Dimaio, Richard P. Moser, Shakeeb Yunus, Thomas J. Fitzgerald, Urvashi Upadhyay, Paul Rava, Matthew Tangel, Aaron Yao, and Sangam Kanekar

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Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates, Omid Veiseh, Dale L. Greiner, and Daniel G. Anderson

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Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice, Aditya Venkatesh, Shan Ma, Yun Z. Le, Michael N. Hall, Markus A. Ruegg, and Claudio Punzo

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An effective approach to diagnosis and surgical repair of refractory medial epicondylitis, Amrit V. Vinod and Glen Ross

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Weekly Treatment of 2-Hydroxypropyl-beta-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice, Sofie M.A. Walenbergh, Tom Houben, Tim Hendrikx, Mike L.J. Jeurissen, Patrick J. van Gorp, Nathalie Vaes, Steven W.M. Olde Damink, Fons Verheyen, Ger H. Koek, Dieter Lutjohann, Alena Grebe, Eicke Latz, and Ronit Shiri-Sverdlov

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Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction, Tao Wang, Chenchen Xu, Xiping Zhou, Chunjia Li, Hongbing Zhang, Bill Q. Lian, Jonathan J. Lee, Jun Shen, Yuehua Liu, and Christine Guo Lian

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Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States, John E. Ware Jr., Barbara L. Gandek, Anuradha Kulasekaran, and Rick Guyer

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Cervical cancer screening and follow-up in 4 geographically diverse US health care systems, 1998 through 2007, Sheila Weinmann, Andrew E. Williams, Aruna Kamineni, Diana S.M. Buist, Erin E. Masterson, Natasha K. Stout, Azadeh Stark, Tyler R. Ross, Christopher L. Owens, Terry S. Field, and Chyke A. Doubeni

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Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection, Darin L. Wiesner, Charles A. Specht, Chrono K. Lee, Kyle D. Smith, Liliane Mukaremera, S. Thera Lee, Chun G. Lee, Jack A. Elias, Judith N. Nielsen, David R. Boulware, Paul R. Bohjanen, Marc K. Jenkins, Stuart M. Levitz, and Kirsten Nielsen

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Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology, Hanna Witwicka, Sung-Yong Hwang, Pablo Reyes-Gutierrez, Hong Jia, Paul E. Odgren, Leah Rae Donahue, Mark J. Birnbaum, and Paul R. Odgren

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TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption, Hanna Witwicka, Hong Jia, Artem B. Kutikov, Pablo Reyes-Gutierrez, Xiang-Dong Li, and Paul R. Odgren

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TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection, Tuoqi Wu, HyunMu Shin, E. Ashley Moseman, Yun Ji, Bonnie Huang, Christelle Harly, Jyoti M. Sen, Leslie J. Berg, Luca Gattinoni, Dorian B. McGavern, and Pamela L. Schwartzberg

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Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets, Chaoxing Yang, Matthias Loehn, Agata Jurczyk, Natalia Przewozniak, Linda Leehy, Pedro L. Herrera, Leonard D. Shultz, Dale L. Greiner, David Harlan, and Rita Bortell

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FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions, Dejun Yang, Abbas Abdallah, Zhaodong Li, Yubing Lu, Sandra Almeida, and Fen-Biao Gao

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Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis, Ning Yang, Li Li, Thibaut Eguether, John P. Sundberg, Gregory J. Pazour, and Jiang Chen

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Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis, Ning Yang, Li Li, Thibaut Eguether, John P. Sundberg, Gregory J. Pazour, and Jiang Chen

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Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells, Qianting Yang, Qian Xu, Qi Chen, Jin Li, Mingxia Zhang, Yi Cai, Haiying Liu, Yiping Zhou, Guofang Deng, Qunyi Deng, Boping Zhou, Hardy Kornfeld, and Xinchun Chen

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Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response, Seungchan Yang, Alexandre Jose Christino Quaresma, Jeffrey A. Nickerson, Karin M. Green, Scott A. Shaffer, Anthony N. Imbalzano, Lori A. Martin-Buley, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption, Liang Ye, Leslie R. Morse, Li Zhang, Hajime Sasaki, Jason C. Mills, Paul R. Odgren, Greg Sibbel, James R.L. Stanley, Gee Wong, Ariane Zamarioli, and Ricardo A. Battaglino

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DeTEXT: A Database for Evaluating Text Extraction from Biomedical Literature Figures, Xu-Cheng Yin, Chun Yang, Wei-Yi Pei, Haixia Man, Jun Zhang, Erik Learned-Miller, and Hong Yu

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High rate of subclinical chikungunya virus infection and association of neutralizing antibody with protection in a prospective cohort in the Philippines, In-Kyu Yoon, Maria Theresa Alera, Catherine B. Lago, Ilya A. Tac-An, Daisy Villa, Stefan Fernandez, Butsaya Thaisomboonsuk, Chonticha Klungthong, Jens W. Levy, John Mark Velasco, Vito G. Roque Jr., Henrik Salje, Louis R. Macareo, Laura L. Hermann, Ananda Nisalak, and Anon Srikiatkhachorn

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Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila, Yeliz Yuva-Aydemir, Xia-Lian Xu, Ozkan Aydemir, Eduardo Gascon, Serkan Sayin, Wenke Zhou, Yang Hong, and Fen-Biao Gao

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An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system, Denise A. Zannino and Charles G. Sagerstrom

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Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing, Li Zhang, Ngoc-Tung Tran, Hairui Su, Rui Wang, Yuheng Lu, Haiping Tang, Sayura Aoyagi, Ailan Guo, Alireza Khodadadi-Jamayran, Dewang Zhou, Kun Qian, Todd Hricik, Jocelyn Cote, Xiaosi Han, Wenping Zhou, Suparna Laha, Omar Abdel-Wahab, Ross L. Levine, Glen Raffel, Yanyan Liu, Dongquan Chen, Haitao Li, Tim Townes, Hengbin Wang, Haiteng Deng, Yujun George Zheng, Christina Leslie, Minkui Luo, and Xinyang Zhao

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Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections, Shen-Ying Zhang, Anne Marie Comeau, Jean-Laurent Casanova, Kaan Boztug, and Luigi D. Notarangelo

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Cluster-based Epidemic Control Through Smartphone-based Body Area Networks, Zhaoyang Zhang, Honggang Wang, Chonggang Wang, and Hua (Julia) Fang

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A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation, Huaying Zhao, Kimberly A. Crowley, Craig L. Peterson, Sarah G. Swygert, and Peter Schuck

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Local sequence assembly reveals a high-resolution profile of somatic structural variations in 97 cancer genomes, Jiali Zhuang and Zhiping Weng

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Progression of Large Lymphoma Is Significantly Impeded with a Combination of Gemcitabine Chemotherapy and Dendritic Cells Intra-Tumor Vaccination, Xue-Jun Zhu, Zhongfa Yang, Jin-Yong Zhou, Li Liu, Xue-Mei Sun, Zhen-Fang Fan, Shou-You Hu, Yu-Chao Chen, Wei-Xia Li, Meng Cao, and Li-Xin Wang

Publications from 2014

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Induction of IL-12 production in human peripheral monocytes by Trypanosoma cruzi Is mediated by glycosylphosphatidylinositol-anchored mucin-like glycoproteins and potentiated by IFN- gamma and CD40-CD40L interactions, Lucia Cristina Abel Jamli, Ludmila Rodrigues Ferreira Pinto, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo T. Gazzinelli, Luiz Vicente Rizzo, and Edecio Cunha-Neto

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Post-Autologous (ASCT) Stem Cell Transplant Therapy in Multiple Myeloma, Zeina Al-Mansour and Muthalagu Ramanathan

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The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria, Lis R.V. Antonelli, Fabiana M.S. Leoratti, Pedro A.C. Costa, Bruno C. Rocha, Suelen Q. Diniz, Mauro S. Tada, Dhelio B. Pereira, Andrea Teixeira-Carvalho, Douglas T. Golenbock, Ricardo Goncalves, and Ricardo T. Gazzinelli

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The home environment and childhood obesity in low-income households: indirect effects via sleep duration and screen time, Bradley M. Appelhans, Stephanie L. Fitzpatrick, Hong Li, Vernon Cail, Molly E. Waring, Kristin L. Schneider, Matthew C. Whited, Andrew M. Busch, and Sherry L. Pagoto

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Genetic vaccination against experimental infection with myotropic parasite strains of Trypanosoma cruzi, Adriano Fernando Araujo, Gabriel de Oliveira, Juliana Fraga Vasconcelos, Jonatan Ersching, Mariana Ribeiro Dominguez, Jose Ronnie Vasconcelos, Alexandre Vieira Machado, Ricardo T. Gazzinelli, Oscar Bruna-Romero, Milena Botelho Soares, and Mauricio Martins Rodrigues

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Human breast progenitor cell numbers are regulated by WNT and TBX3, Lisa M. Arendt, Jessica St. Laurent, Ania Wronski, Silvia Caballero, Stephen Lyle, Stephen P. Naber, and Charlotte Kuperwasser

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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection, Marco A. Ataide, Warrison A. Andrade, Dario S. Zamboni, Donghai Wang, Maria do Carmo Souza, Bernardo S. Franklin, Samir Elian, Flaviano S. Martins, Dhelio Pereira, George W. Reed, Katherine A. Fitzgerald, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone, Junya Awata, Saeko Takada, Clive Standley, Karl-Ferdinand Lechtreck, Karl D. Bellve, Gregory J. Pazour, Kevin E. Fogarty, and George B. Witman

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Joint replacement registries in the United States: a new paradigm, David C. Ayers and Patricia D. Franklin

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High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody, Gregory J. Babcock, Sowmya Iyer, Heidi L. Smith, Yan Wang, Kirk Rowley, Donna M. Ambrosino, Phillip D. Zamore, Brian G. Pierce, Deborah C. Molrine, and Zhiping Weng

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Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals, Shashi Bala, Miguel Marcos, Arijeet Gattu, Donna Catalano, and Gyongyi Szabo

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Protective immunity and safety of a genetically modified influenza virus vaccine, Rafael Polidoro Alves Barbosa, Ana Paula Carneiro Salgado, Cristiana Couto Garcia, Bruno Galvao Filho, Ana Paula de Faria Paula de Faria Goncalves, Braulio Henrique Freire Lima, Gabriel Augusto Oliveira Lopes, Milene Alvarenga Rachid, Andiara Cristina Cardoso Peixoto, Danilo Bretas de Oliveira, Marco Antonio Ataide, Carla Aparecida Zirke, Tatiane Marques Cotrim, Erica Azevedo Costa, Gabriel Magno de Freitas Almeida, Remo Castro Russo, Ricardo T. Gazzinelli, and Alexandre de Magalhaes Vieira Machado

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The relationship between subnormal peak-stimulated growth hormone levels and auxological characteristics in obese children, Jefferson Barrett, Louise S. Maranda, and Benjamin U. Nwosu

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Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA, Hanni Bartels and Jeremy Luban

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The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter, Rasim Barutcu, Phillip W. Tai, Hai Wu, Jonathan A. R. Gordon, Troy W. Whitfield, Jason Dobson, Anthony N. Imbalzano, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein, and Gary S. Stein

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A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior, Raja Bhattacharya, Denis Touroutine, Belinda Barbagallo, Jason Climer, Christopher M. Lambert, Christopher M. Clark, Mark J. Alkema, and Michael M. Francis

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The spatial dynamics of dengue virus in Kamphaeng Phet, Thailand, Piraya Bhoomiboonchoo, Robert V. Gibbons, Angkana Huang, In-Kyu Yoon, Darunee Buddhari, Ananda Nisalak, Natkamol Chansatiporn, Mathuros Thipayamongkolgul, Siripen Kalanarooj, Timothy Endy, Alan L. Rothman, Anon Srikiatkhachorn, Sharone Green, Mammen P. Mammen, Derek A. Cummings, and Henrik Salje

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A survey study of evidence-based medicine training in US and Canadian medical schools, Maria A. Blanco, Carol F. Capello, Josephine L. Dorsch, Gerald (Jerry) Perry, and Mary L. Zanetti

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A randomized controlled trial of mental health interventions for survivors of systematic violence in Kurdistan, Northern Iraq, Paul Bolton, Judith K. Bass, Goran Zangana, Talar Kamal, Sarah Murray, Debra Kaysen, Carl W. Lejuez, Kristen Lindgren, Sherry L. Pagoto, Laura K. Murray, Stephanie Van Wyk, Ahmed Ahmed, Nazar M. Mohammad Amin, and Michael Rosenblum

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Dengue virus neutralizing antibody levels associated with protection from infection in Thai cluster studies, Darunee Buddhari, Jared Aldstadt, Timothy P. Endy, Anon Srikiatkhachorn, Butsaya Thaisomboonsuk, Chonticha Klungthong, Ananda Nisalak, Benjawan Khuntirat, Richard G. Jarman, Stefan Fernandez, Stephen J. Thomas, Thomas W. Scott, Alan L. Rothman, and In-Kyu Yoon

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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90, Terence N. Bukong, Fatemeh Momen-Heravi, Karen Kodys, Shashi Bala, and Gyongyi Szabo

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A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells, Pengxing Cao, Xiahui Tan, Graham Donovan, Michael J. Sanderson, and James Sneyd

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Antiplatelet activity, P2Y(1) and P2Y(1)(2) inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'''-P(1) ,P(4)-dithio-P(2),P(3)-chloromethylenetetraphosphate, Hung Chang, Ivan B. Yanachkov, Edward J. Dix, Milka Yanachkova, Youfu Li, Marc R. Barnard, George E. Wright, Alan D. Michelson, and Andrew L. Frelinger III

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Estudio Parto: postpartum diabetes prevention program for hispanic women with abnormal glucose tolerance in pregnancy: a randomised controlled trial - study protocol, Lisa Chasan-Taber, Bess H. Marcus, Milagros C. Rosal, Katherine L. Tucker, Sheri J. Hartman, Penelope S. Pekow, Barry Braun, Tiffany A. Moore Simas, Caren G. Solomon, Joann E. Manson, and Glenn Markenson

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Unbiased chromatin accessibility profiling by RED-seq uncovers unique features of nucleosome variants in vivo, Poshen B. Chen, Lihua Julie Zhu, Sarah J. Hainer, Kurtis N. McCannell, and Thomas G. Fazzio

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Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival, Yaoyu Chen, Cong Peng, Sheela A. Abraham, Yi Shan, Zhiru Guo, Ngoc Desouza, Giulia Cheloni, Dongguang Li, Tessa L. Holyoake, and Shaoguang Li

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Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport, Kyoko Chiba, Masahiko Araseki, Keisuke Nozawa, Keiko Furukori, Yoichi Araki, Takahide Matsushima, Tadashi Nakaya, Saori Hata, Yuhki Saito, Seiichi Uchida, Yasushi Okada, Angus C. Nairn, Roger J. Davis, Tohru Yamamoto, Masataka Kinjo, Hidenori Taru, and Toshiharu Suzuki

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Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite, Carina C. Clingman, Laura M. Deveau, Samantha A. Hay, Ryan M. J. Genga, Shivender Shandilya, Francesca Massi, and Sean P. Ryder

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Psychopathic traits modulate brain responses to drug cues in incarcerated offenders, Lora M. Cope, Gina M. Vincent, Justin L. Jobelius, Prashanth K. Nyalakanti, Vince D. Calhoun, and Kent A. Kiehl

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Blank-comparison matching-to-sample reveals a false positive symmetry test in a capuchin monkey, Ana Leda de Faria Brino, Rodolfo da Silva Campos, Olavo de Faria Galvao, and William J. McIlvane

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Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA, Alberto De Iaco and Jeremy Luban

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Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture, Job Dekker

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Quitters referring smokers: a quitline chain-referral pilot study, Kathryn L. Delaughter, Julie E. Volkman, Barrett D. Phillips, and Thomas K. Houston

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Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast, Noah Dephoure, Sunyoung Hwang, Ciara O'Sullivan, Stacie E. Dodgson, Steven P. Gygi, Angelika Amon, and Eduardo M. Torres

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IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion, Tanay M. Desai, Mariana Marin, Christopher R. Chin, George Savidis, Abraham L. Brass, and Gregory B. Melikyan

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hsa-mir-30c promotes the invasive phenotype of metastatic breast cancer cells by targeting NOV/CCN3, Jason R. Dobson, Hanna Taipaleenmaki, Yu-Jie Hu, Deli Hong, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Jitesh Pratap

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PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury, Johnna E. Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-yi Lu, and Marc R. Freeman

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Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, Shuping Dou, John Virostko, Mary Rusckowski, Dale L. Greiner, Alvin C. Powers, and Guozheng Liu

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TLR4 activation induces IL-1ss release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung, Suffwan Eltom, Maria G. Belvisi, Liang Yew-Booth, Bilel Dekkak, Sarah A. Maher, Eric D. Dubuis, Victoria Jones, Kate A. Fitzgerald, and Mark A. Birrell

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Histamine impairs midbrain dopaminergic development in vivo by activating histamine type 1 receptors, Itzel Escobedo-Avila, Fernanda Vargas-Romero, Anayansi Molina-Hernandez, Rodrigo Lopez-Gonzalez, Daniel Cortes, Juan A. De Carlos, and Ivan Velasco

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Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila, Yun Fan, Shiuan Wang, Jacob Hernandez, Vildan Betul Yenigun, Gillian Hertlein, Caitlin E. Fogarty, Jillian L. Lindblad, and Andreas Bergmann

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Approaches for classifying the indications for colonoscopy using detailed clinical data, Hirut Fassil, Kenneth F. Adams, Sheila Weinmann, V. Paul Doria-Rose, Eric Johnson, Andrew E. Williams, Douglas A. Corley, and Chyke A. Doubeni

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Evaluation of naturally acquired IgG antibodies to a chimeric and non-chimeric recombinant species of Plasmodium vivax reticulocyte binding protein-1: lack of association with HLA-DRB1*/DQB1* in malaria exposed individuals from the Brazilian Amazon, Amanda Ribeiro Ferreira, Balwan Singh, Monica Cabrera-Mora, Alana Cristina Magri De Souza, Maria Teresa Queiroz Marques, Luis Cristovao Sobrino Porto, Fatima Santos, Dalma Maria Banic, J. Mauricio Calvo-Calle, Joseli Oliveira-Ferreira, Alberto Moreno, and Josue Da Costa Lima-Junior

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Influenza virus drug resistance: a time-sampled population genetics perspective, Matthieu Foll, Yu Ping Poh, Nicholas Renzette, Anna Ferrer Admetlla, Claudia Bank, Hyunjin Shim, Anna Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R. Caffrey, Konstantin B. Zeldovich, Daniel N. A. Bolon, Jennifer Wang, Timothy F. Kowalik, Celia A. Schiffer, Robert W. Finberg, and Jeffrey D. Jensen

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Should patients with acute coronary disease be stratified for management according to their risk? Derivation, external validation and outcomes using the updated GRACE risk score, Keith A. A. Fox, Gordon FitzGerald, Etienne Puymirat, Wei Huang, Kathryn Carruthers, Tabassome Simon, Pierre Coste, Jacques Monsegu, Phillippe Gabriel Steg, Nicolas Danchin, and Frederick A. Anderson Jr.

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Upper extremity injury management by non-physician emergency practitioners in rural Uganda: A pilot study, Daniel S. Frank, Katie Dunleavy, Rashidah Nambaziira, Irene Nayebare, Bradley Dreifuss, and Mark Bisanzo

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Implementation of patient-reported outcome measures in U.S. Total joint replacement registries: rationale, status, and plans, Patricia D. Franklin, David Lewallen, Kevin Bozic, Brian Hallstrom, William Jiranek, and David C. Ayers

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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, and Albertha J. M. Walhout

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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection, Don B. Gammon, Sophie Duraffour, Daniel K. Rozelle, Heidi Hehnly, Rita Sharma, Michael E. Sparks, Cara C. West, Ying Chen, James J. Moresco, Graciela Andrei, John H. Connor, Darryl Conte Jr., Dawn E. Gundersen-Rindal, William L. Marshall, John R. Yates, Neal S. Silverman, and Craig C. Mello

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Fidelity of Histone Gene Regulation is Obligatory for Genome Replication and Stability, Prachi N. Ghule, Ronglin Xie, Ricardo F. Medina, Jennifer L. Colby, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein

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An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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An improved predictive recognition model for Cys2-His2 zinc finger proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, and Gary D. Stormo

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The rheumatoid arthritis treat-to-target trial: a cluster randomized trial within the Corrona rheumatology network, Leslie R. Harrold, George W. Reed, J. Timothy Harrington, Christine J. Barr, Katherine C. Saunders, Allan Gibofsky, Jeffrey D. Greenberg, Ani John, Jenny Devenport, and Joel M. Kremer

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The comparative effectiveness of abatacept versus anti-tumour necrosis factor switching for rheumatoid arthritis patients previously treated with an anti-tumour necrosis factor, Leslie R. Harrold, George W. Reed, Joel M. Kremer, Jeffrey R. Curtis, Daniel H. Solomon, Marc C. Hochberg, and Jeffrey D. Greenberg

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Teaching tobacco dependence treatment and counseling skills during medical school: rationale and design of the Medical Students helping patients Quit tobacco (MSQuit) group randomized controlled trial, Rashelle B. Hayes, Alan C. Geller, Linda C. Churchill, Denise G. Jolicoeur, David M. Murray, Abigail Shobend, Sean P. David, Michael Adams, Kola Okuyemi, Randy Fauver, Robin Gross, Frank Leone, Rui Xiao, Jonathan Waugh, Sybil L. Crawford, and Judith K. Ockene

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Myogenic Enhancers Regulate Expression of the Facioscapulohumeral Muscular Dystrophy-Associated DUX4 Gene, Charis L. Himeda, Celine Debarnot, Sachiko Homma, Mary Lou Beermann, Jeffrey B. Miller, Peter L. Jones, and Takako I. Jones

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MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis, Andrew G. Hoss, Vinay K. Kartha, Xianjun Dong, Jeanne C. Latourelle, Alexandra Dumitriu, Tiffany C. Hadzi, Marcy E. Macdonald, James F. Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, and Richard H. Myers

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Profiles of acute cytokine and antibody responses in patients infected with avian influenza A H7N9, Rui Huang, Lu Zhang, Qin Gu, Yi-Hua Zhou, Yingying Hao, Kui Zhang, Yong Liu, Danjiang Dong, Shixia Wang, Zuhu Huang, Shan Lu, and Chao Wu

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The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins, Andree Hubber, Kohei Arasaki, Fubito Nakatsu, Camille Hardiman, David G. Lambright, Pietro De Camilli, Hiroki Nagai, and Craig R. Roy

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin

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Association between Smoking and Health Outcomes in Postmenopausal Women Living with Multiple Sclerosis, Rachel Jawahar, Unsong Oh, Charles Eaton, Nicole Wright, Hilary Tindle, and Kate L. Lapane

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Emergency department patient safety incident characterization: an observational analysis of the findings of a standardized peer review process, Zach K. Jepson, Chad E. Darling, Kevin A. Kotkowski, Steven B. Bird, Michael W. Arce, Gregory A. Volturo, and Martin A. Reznek

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A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling beta-glucan microparticles, Magdia De Jesus, Gary R. Ostroff, Stuart M. Levitz, Toni R. Bartling, and Nicholas J. Mantis

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Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses, Hiroshi Kataoka, Hajime Kono, Zubin Patel, and Kenneth L. Rock

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Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year, Jonathan Kay, Olga Morgacheva, Susan P. Messing, Joel M. Kremer, Jeffrey D. Greenberg, George W. Reed, Ellen M. Gravallese, and Daniel E. Furst

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells, Nicola A. Kearns, Ryan M. J. Genga, Metewo Selase Enuameh, Manuel Garber, Scot A. Wolfe, and Rene Maehr

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Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction, Kimberly S. Kerr, Yuly F. Fuentes Medel, Cassandra Brewer, Romina Barria, James A. Ashley, Katharine C. Abruzzi, Amy E. Sheehan, Ozge E. Tasdemir, Marc R. Freeman, and Vivian Budnik