Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2016

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Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland, Guangyuan Li, Isaac N. Hayward, Brittany R. Jenkins, Heather M. Rothfuss, Coleman H. Young, Marja T. Nevalainen, Aaron Muth, Paul R. Thompson, Amy M. Navratil, and Brian D. Cherrington

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Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation, Mingli Li, Jillian L. Lindblad, Ernesto Perez, Andreas Bergmann, and Yun Fan

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Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection, Pei-Wen Lim, Kate H. Dinh, Mary E. Sullivan, Wahid Y. Wassef, Jaroslav Zivny, Giles F. Whalen, and Jennifer LaFemina

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Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress, Chen Lin, Xinyuan Zhao, Desen Sun, Lingda Zhang, Wenpan Fang, Tingjia Zhu, Qiang Wang, Botao Liu, Saisai Wei, Guangdi Chen, Zhengping Xu, and Xiangwei Gao

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Combining statistics from two national complex surveys to estimate injury rates per hour exposed and variance by activity in the USA, Tin-Chi Lin, Helen R. Marucci-Wellman, Joanna L. Willetts, Melanye J. Brennan, and Santosh K. Verma

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Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning, Dianxin Liu, Marica Bordicchia, Chaoying Zhang, Huafeng Fang, Wan Wei, Jian-Liang Li, Adilson L. Guilherme, Kalyani V. P. Guntur, Michael P. Czech, and Sheila Collins

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Implementation and reporting of causal mediation analysis in 2015: a systematic review in epidemiological studies, Shao-Hsien Liu, Christine M. Ulbricht, Stavroula A. Chrysanthopoulou, and Kate L. Lapane

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DNA immunization as a technology platform for monoclonal antibody induction, Shuying Liu, Shixia Wang, and Shan Lu

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Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon, Wanzhao Liu, Edith L. Pfister, Lori A. Kennington, Kathryn O. Chase, Christian Mueller, Marian DiFiglia, and Neil Aronin

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Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy, Y. Lucy Liu, Shaoguang Li, and Peter D. Emanuel

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Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study, Wenyuan Li, John F. Keaney Jr., and Murray A. Mittleman

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DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia, You Li, Hisato Yagi, Gregory M. Hendricks, Gregory J. Pazour, and Cecilia W. Lo

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Coalicion de Salud Comunitaria (COSACO): using a Healthy Community Partnership framework to integrate short-term global health experiences into broader community development, Lawrence C. Loh, Olga Valdman, and Matthew M. Dacso

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Ribosome*RelA structures reveal the mechanism of stringent response activation, Anna B. Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F. Brilot, Nikolaus Grigorieff, and Andrei A. Korostelev

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Closing the net on retroviruses, Jeremy Luban

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The Causes of HIV-Associated Cardiomyopathy: A Tale of Two Worlds, Rebecca H. Lumsden and Gerald S. Bloomfield

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Accurate Prediction of Transposon-Derived piRNAs by Integrating Various Sequential and Physicochemical Features, Longqiang Luo, Dingfang Li, Wen Zhang, Shikui Tu, Xiaopeng Zhu, and Gang Tian

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Safety of anticoagulation with uninterrupted warfarin vs. interrupted dabigatran in patients requiring an implantable cardiac device, Shivanshu Madan, Purushothaman Muthusamy, Katie L. Mowers, Darryl A. Elmouchi, Bohuslav Finta, Andre J. Gauri, Alan K. Woelfel, Timothy D. Fritz, Alan T. Davis, and Nagib T. Chalfoun

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Decade Long Trends (2001-2011) in Duration of Pre-Hospital Delay Among Elderly Patients Hospitalized for an Acute Myocardial Infarction, Raghavendra Makam, Nathaniel Erskine, Jorge L. Yarzebski, Darleen M. Lessard, Jason Lau, Jeroan J. Allison, Joel M. Gore, Jerry H. Gurwitz, David D. McManus, and Robert J. Goldberg

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Association between Responsible Pet Ownership and Glycemic Control in Youths with Type 1 Diabetes, Louise Maranda and Olga T. Gupta

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Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis, Matthew J. Markert, Ying Zhang, Metewo Selase Enuameh, Steven M. Reppert, Scot A. Wolfe, and Christine Merlin

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Transcriptional Auto-Regulation of RUNX1 P1 Promoter, Milka Martinez, Marcela Hinojosa, Daniel J. Trombly, Violeta Morin, Janet L. Stein, Gary S. Stein, Amjad Javed, and Soraya E. Gutierrez

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Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting, David Mavor, Benjamin P. Roscoe, Daniel N. Bolon, and James S. Fraser

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T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines, Janet E. McElhaney, George A. Kuchel, Xin Zhou, Susan L. Swain, and Laura Haynes

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Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants, Margaret M. McManus, Eric O. Mick, Richard W. Hudson Jr., Lynne M. Mofenson, John L. Sullivan, Mohan Somasundaran, Katherine Luzuriaga, and PACTG 356 Investigators

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A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study, Lidia Minguez-Alarcon, Oleg Sergeyev, Jane S. Burns, Paige L. Williams, Mary M. Lee, Susan A. Korrick, Luidmila Smigulina, Boris Revich, and Russ Hauser

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Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function, Parul Mishra, Julia Flynn, Tyler N. Starr, and Daniel N. Bolon

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Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft, Muhammad M. Mohiuddin, Aaron J. Belli, and Keith A. Reimann

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Apontic regulates somatic stem cell numbers in Drosophila testes, Amanda J. Monahan and Michelle Starz-Gaiano

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Border Security: The Role of RIPK3 in Epithelium Homeostasis, Kenta Moriwaki, Sakthi Balaji, and Francis Ka-Ming Chan

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State-of-the-art monitoring in treatment of dengue shock syndrome: a case series, Steven L. Moulton, Jane Mulligan, Anon Srikiatkhachorn, Siripen Kalanarooj, Greg Z. Grudic, Sharone Green, Robert V. Gibbons, Gary W. Muniz, Carmen Hinojosa-Laborde, Alan L. Rothman, Stephen J. Thomas, and Victor A. Convertino

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Neoatherosclerosis in Very Late Stenosis of Bare Metal Stent by Optical Coherence Tomography, Samer Mowakeaa, Aline Iskandar, and Nikolaos Kakouros

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N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis, Kenan C. Murphy and Carl F. Nathan

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Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper, Derek T. Musashe, Maria D. Purice, Sean D. Speese, Johnna E. Doherty, and Mary A. Logan

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CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis, Kentaro Nagaoka, K. Fujii, H. Zhang, K. Usuda, G. Watanabe, Maria Ivshina, and Joel D. Richter

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Novel oral transforming growth factor-beta signaling inhibitor EW-7197 eradicates CML-initiating cells, Kazuhito Naka, Shaoguang Li, and Dae-Kee Kim

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A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling, Clíona Ní Cheallaigh, Jinhee Lee, Kim West, Nuria Martinez, Hardy Kornfeld, Douglas T. Golenbock, and Ed C. Lavelle

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Clinical expression of facioscapulohumeral muscular dystrophy in carriers of 1-3 D4Z4 reduced alleles: experience of the FSHD Italian National Registry, Ana Nikolic and Rossella Tupler

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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium, Faye L. Norby and David D. McManus

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SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin, Kentaro Ohkuni, Yoshimitsu Takahashi, Alyona Fulp, Josh Lawrimore, Wei-Chun Au, Nagesh Pasupala, Reuben Levy-Myers, Jack Warren, Alexander Strunnikov, Richard E. Baker, Oliver Kerscher, Kerry Bloom, and Munira A. Basrai

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Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation, Kendi Okuda, Mei Tong, Brian Dempsey, Kathryn J. Moore, Ricardo T. Gazzinelli, and Neal S. Silverman

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The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles, Mariam H. Orme, Meghana Tare, Andreas Bergmann, and Pascal Meier

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A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome, Machteld M. Oud, Gregory J. Pazour, Bruno Reversade, and Heleen H. Arts

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Adapting Behavioral Interventions for Social Media Delivery, Sherry L. Pagoto, Molly E. Waring, Christine N. May, Eric Y. Ding, Werner H. Kunz, Rashelle B. Hayes, and Jessica L. Oleski

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Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock, James Park, Haisun Zhu, Sean O'Sullivan, Babatunde A. Ogunnaike, David R. Weaver, James S. Schwaber, and Rajanikanth Vadigepalli

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Newer Oral Anticoagulants: Stroke Prevention and Pitfalls, Anand Patel, Richard P. Goddeau, and Nils Henninger

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Unilateral Eye Findings: A Rare Herald of Acute Leukemia, Avni V. Patel, John B. Miller, Rajneesh Nath, Helen A. Shih, Michael K. Yoon, Suzanne K. Freitag, George Papaliodis, Teresa C. Chen, Dean Eliott, and Ivana K. Kim

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The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L, Victoria E. Pedanou, Stephane Gobeil, Sebastien Tabaries, Tessa M. Simone, Lihua Julie Zhu, Peter M. Siegel, and Michael R. Green

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How Would Children Register Their Own Births? Insights from a Survey of Students Regarding Birth Registration Knowledge and Policy Suggestions in Kenya, Matthew Pelowski, Richard G. Wamai, Joseph Wangombe, Hellen Nyakundi, Geofrey O. Oduwo, Benjamin K. Ngugi, and Javier Gordon Ogembo

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Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells, Lana M. Pollock, Nilay Gupta, Xi Chen, Elizabeth J. Luna, and Brian M. McDermott Jr (PloS one)

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Preparing Future Leaders: An Integrated Quality Improvement Residency Curriculum, Stacy E. Potts, Sara G. Shields, and Carole C. Upshur

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CpG Improves Influenza Vaccine Efficacy in Young Adult but Not Aged Mice, Alejandor Ramirez, Mary Dawn T. Co, and Anuja Mathew

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Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development, Kasmir Ramo, Koichi Sugamura, Siobhan M. Craige, John F. Keaney Jr., and Roger J. Davis

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The carboxyl terminal mutational hotspot of the ciliary disease protein RPGRORF15 (retinitis pigmentosa GTPase regulator) is glutamylated in vivo, Kollu N. Rao, Manisha Anand, and Hemant Khanna

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Cardiovascular health awareness and the effect of an educational intervention on school-aged children in a rural district of India, Madhab Ray, Santanu Guha, Meghna Ray, Anita Kundu, Bipasha Ray, Kaushik Kundu, Santanu Goswami, Deepak Bhatt, Harry P. Selker, and Robert J. Goldberg

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A novel clinical tool to classify facioscapulohumeral muscular dystrophy phenotypes, Giulia Ricci and Rossella Ginevra Tupler

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The E-Coach technology-assisted care transition system: a pragmatic randomized trial, Christine S. Ritchie, Thomas K. Houston, Joshua S. Richman, Heather J. Sobko, Eta S. Berner, Benjamin B. Taylor, Amanda H. Salanitro, and Julie L. Locher

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Cancer of the uterus and treatment of stress incontinence: a pilot study, Katina Robison, Elizabeth Lokich, Sonali Raman, Christine Luis, Christina Raker, Melissa A. Clark, and Kyle Wohlrab

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Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia, Rachel J. Roth Flach, Laura V. Danai, Marina DiStefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, and Michael P. Czech

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Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function, Rachel J. Roth Flach, Chang-An Guo, Laura V. Danai, Joseph C. Yawe, Sharvari Gujja, Yvonne J.K. Edwards, and Michael P. Czech

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Impact of a family medicine resident wellness curriculum: a feasibility study, Christine Runyan, Judith A. Savageau, Stacy E. Potts, and Linda F. Weinreb

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Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission, Henrik Salje and Anon Srikiatkhachorn

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An exploration of the role of religion/spirituality in the promotion of physicians' wellbeing in Emergency Medicine, Elena Salmoirago-Blotcher, George Fitchett, Katherine Leung, Gregory A. Volturo, Edwin D. Boudreaux, Sybil L. Crawford, Ira S. Ockene, and Farr Curlin

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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion, David E. Saslowsky, Jay R. Thiagarajah, Beth A. McCormick, Jean C. Lee, and Wayne I. Lencer

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beta1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation, Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming Ii, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino

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Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression, Dorothy P. Schafer, Christopher T. Heller, Georgia Gunner, Molly Heller, Christopher Gordon, Timothy Hammond, Yochai Wolf, Steffen Jung, and Beth Stevens

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Twenty-Five Year Secular Trends in Lipids and Modifiable Risk Factors in a Population-Based Biracial Cohort: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 1985-2011, Pamela J. Schreiner, David R. Jacobs Jr, Nathan D. Wong, and Catarina I. Kiefe

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Tanning bed burns reported on Twitter: over 15,000 in 2013, Andrew B. Seidenberg, Sherry L. Pagoto, Theodore A. Vickey, Eleni Linos, Mackenzie R. Wehner, Renata Dalla Costa, and Alan C. Geller

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Performance of rapid SOFIA Influenza A+B test compared to Luminex x-TAG respiratory viral panel assay in the diagnosis of influenza A, B, and subtype H3, William Selove and Lokinendi V. Rao

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Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources, Ravi Shah, Kahraman Tanriverdi, Daniel Levy, Martin Larson, Mark B. Gerstein, Eric O. Mick, Joel Rozowsky, Robert Kitchen, Venkatesh Murthy, Ekaterina Mikalev, and Jane E. Freedman

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IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis, Anita T. Shaw, Yukiko Maeda, and Ellen M. Gravallese

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Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration, Jihae Shin, Johnny S. Salameh, and Joel D. Richter

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Neural Integration Underlying a Time-Compensated Sun Compass in the Migratory Monarch Butterfly, Eli Shlizerman, James Phillips-Portillo, Daniel B. Forger, and Steven M. Reppert

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Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability, M. Catarina Silva, Sandra Almeida, Md Helal Uddin Biswas, Zhijun Zhang, Fen-Biao Gao, and Stephen J. Haggarty

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Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation, Lorissa J. Smulan, Wei Ding, Elizaveta Freinkman, Sharvari Gujja, Yvonne J. Edwards K, and Amy K. Walker

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Prevention of sexual transmission of Ebola in Liberia through a national semen testing and counselling programme for survivors: an analysis of Ebola virus RNA results and behavioural data, Moses J. Soka, Mary J. Choi, Christine Wasunna, and Jeffrey A. Bailey

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Association of common mental disorder symptoms with health and healthcare factors among women in rural western India: results of a cross-sectional survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, and Somashekhar Nimbalkar

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Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism, Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo, and David A. Guertin

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Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition, Michelle D. Tate, James D.H. Ong, Jennifer K. Dowling, Julie L. McAuley, Avril B. Robertson, Eicke Latz, Grant R. Drummond, Matthew A. Cooper, Paul J. Hertzog, and Ashley Mansell

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MMB-GUI: a fast morphing method demonstrates a possible ribosomal tRNA translocation trajectory, Alex Tek, Andrei A. Korostelev, and Samuel Coulbourn Flores

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Scaffolded Antigens in Yeast Cell Particle Vaccines Provide Protection against Systemic Polyoma Virus Infection, Donald J. Tipper and Eva Szomolanyi-Tsuda

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A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, and Douglas T. Golenbock

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Physical Activity-Related Policy and Environmental Strategies to Prevent Obesity in Rural Communities: A Systematic Review of the Literature, 2002-2013, M. Renée Umstattd Meyer, Cynthia K. Perry, Jasmin C. Sumrall, Megan S. Patterson, Shana M. Walsh, Stephanie C. Clendennen, Steven P. Hooker, Kelly R. Evenson, Karin V. Goins, Katie M. Heinrich, Nancy O'Hara Tompkins, Amy A. Eyler, Sydney Jones, Rachel Tabak, and Cheryl Valko

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Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans, Rajendra Upadhya, Woei C. Lam, Brian Maybruck, Charles A. Specht, Stuart M. Levitz, and Jennifer K. Lodge

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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Tara Vanderweyde, John D. Leszyk, and Benjamin Wolozin

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Dynamics of Nucleosome Positioning Maturation following Genomic Replication, Pauline Vasseur, Saphia Tonazzini, Rahima Ziane, Alain Camasses, Oliver J. Rando, and Marta Radman-Livaja

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An alternative splicing program promotes adipose tissue thermogenesis, Santiago Vernia, Yvonne J. K. Edwards, Myoung Souk Han, Julie Cavanagh-Kyros, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress, Santiago Vernia, Caroline Morel, Joseph C. Madara, Julie Cavanagh-Kyros, Tamera Barrett, Kathryn O. Chase, Norman J. Kennedy, Dae Young Jung, Jason K. Kim, Neil Aronin, Richard A. Flavell, Bradford B. Lowell, and Roger J. Davis

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Human basal body basics, Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly, and Stephen J. Doxsey

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NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions, Katerina Vlantis, Andy Wullaert, Apostolos Polykratis, Vangelis Kondylis, Marius Dannappel, Robin Schwarzer, Patrick Welz, Teresa Corona, Henning Walczak, Falk Weih, Ulf Klein, Michelle Kelliher, and Manolis Pasparakis

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Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants, Doyle V. Ward, Matthias Scholz, Moreno Zolfo, Diana H. Taft, Kurt R. Schibler, Adrian Tett, Nicola Segata, and Ardythe L. Morrow

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Standardizing disease-specific quality of life measures across multiple chronic conditions: development and initial evaluation of the QOL Disease Impact Scale (QDIS(R)), John E. Ware Jr., Barbara Gandek, Rick Guyer, and Nina Deng

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Interest in a Twitter-delivered weight loss program among women of childbearing age, Molly E. Waring, Kristin L. Schneider, Bradley M. Appelhans, Tiffany A. Moore Simas, Rui Xiao, Matthew C. Whited, Andrew M. Busch, Martinus M. Evans, and Sherry L. Pagoto

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Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans, Emma Watson, Viridiana Olin-Sandoval, Michael J. Hoy, Chi-Hua Li, Timo Louisse, Victoria Yao, Akihiro Mori, Amy D. Holdorf, Olga G. Troyanskaya, Markus Ralser, and Albertha J. M. Walhout

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ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis, Jessica L. Weatherbee, Jean-Louis Kraus, and Alonzo H. Ross

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Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy, Richard G. Weleber, Mark E. Pennesi, David J. Wilson, Shalesh Kaushal, Laura R. Erker, Lauren Jensen, Maureen T. McBride, Terence R. Flotte, Margaret Humphries, Roberto Calcedo, William W. Hauswirth, Jeffrey D. Chulay, and J. Timothy Stout

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Trajectories of functional decline in knee osteoarthritis: the Osteoarthritis Initiative, Daniel K. White, Tuhina Neogi, Uyen Sa D. T. Nguyen, Jingbo Niu, and Yuqing Zhang

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CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia, Kelly L. Williams, Jason Kost, Robert H. Brown Jr., John E. Landers, and Ian P. Blair

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PI3-kinase mutation linked to insulin and growth factor resistance in vivo, Jonathon N. Winnay, Marie H. Solheim, Ercument Dirice, Masaji Sakaguchi, Hye Lim Noh, Hee Joon Kang, Hirokazu Takahashi, Kishan K. Chudasama, Jason K. Kim, Anders Molven, C. Ronald Kahn, and Pal R. Njolstad

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The unmet need in rheumatology: reports from the Targeted Therapies meeting 2016, Kevin Winthrop and Jonathan Kay