Open Access is free, unrestricted, online access to scientific and scholarly research. This collection includes Open Access journal articles authored by researchers, faculty, staff, and students of the University of Massachusetts Medical School.

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Publications from 2015

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Epigenomics and the structure of the living genome, Nir Friedman and Oliver J. Rando

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Marginal structural models for the estimation of the risk of Diabetes Mellitus in the presence of elevated depressive symptoms and antidepressant medication use in the Women's Health Initiative observational and clinical trial cohorts, Christine Frisard, Xiangdong Gu, Brian Whitcomb, Yunsheng Ma, Penelope Pekow, Martha Zorn, Deidre M. Sepavich, and Raji Balasubramanian

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AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, and Ronald C. Desrosiers

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Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody, Uri Galili

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Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice, Michal Ganz, Terence N. Bukong, Timea Csak, Banishree Saha, Jin-Kyu Park, Aditya Ambade, Karen Kodys, and Gyongyi Szabo

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An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis, Neeta Garg and Thomas W. Smith

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A randomized controlled trial of smartphone-based mindfulness training for smoking cessation: a study protocol, Kathleen A. Garrison, Prasanta Pal, Rahil Rojiani, Jesse Dallery, Stephanie S. O'Malley, and Judson A. Brewer

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Predictors for long-term survival free from whole brain radiation therapy in patients treated with radiosurgery for limited brain metastases, Daniel Gorovets, Paul Rava, Daniel K. Ebner, David J. Tybor, Deus Cielo, Yakub Puthawala, Timothy J. Kinsella, Thomas A. DiPetrillo, David E. Wazer, and Jaroslaw T. Hepel

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Civilian deaths from weapons used in the Syrian conflict, Debarati Guha-Sapir, Jose M. Rodriguez-Llanes, Madelyn J. Hsiao-Rei Hicks, Anne-Francoise Donneau, Adam Coutts, Louis Lillywhite, and Fouad M. Fouad

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Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics, Sunita Gulati, Ian C. Schoenhofen, Dennis M. Whitfield, Andrew D. Cox, Jianjun Li, Frank St Michael, Evgeny V. Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A. Lewis, Rachel E. Taylor, Corinna S. Landig, Sandra Diaz, George W. Reed, Ajit Varki, Peter A. Rice, and Sanjay Ram

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Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome, Sarah J. Hainer and Thomas G. Fazzio

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Spatial re-organization of myogenic regulatory sequences temporally controls gene expression, Akihito Harada, Chandrashekara Mallappa, Seiji Okada, John T. Butler, Stephen P. Baker, Jeanne B. Lawrence, Yasuyuki Ohkawa, and Anthony N. Imbalzano

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Comparative effectiveness and safety of rituximab versus subsequent anti-tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti-tumor necrosis factor therapies in the United States Corrona registry, Leslie R. Harrold, George W. Reed, Robert P. Magner, Ashwini Shewade, Ani John, Jeffrey D. Greenberg, and Joel M. Kremer

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Effectiveness of Rituximab for the Treatment of Rheumatoid Arthritis in Patients with Prior Exposure to Anti-TNF: Results from the CORRONA Registry, Leslie R. Harrold, George W. Reed, Ashwini Shewade, Robert P. Magner, Katherine Saunders, Ani John, Joel M. Kremer, and Jeffrey D. Greenberg

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Feasibility of an Assessment Tool for Children's Competence to Consent to Predictive Genetic Testing: a Pilot Study, Irma M. Hein, Pieter W. Troost, Robert Lindeboom, Imke Christiaans, Thomas Grisso, Johannes B. van Goudoever, and Ramon J.L. Lindauer

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Near-infrared photoactivatable control of Ca signaling and optogenetic immunomodulation, Lian He, Yuanwei Zhang, Guolin Ma, Peng Tan, Zhan Jun Li, Shengbing Zhang, Xiang Wu, Ji Jing, Shaohai Fang, Lijuan Zhou, Youjun Wang, Yun Huang, Patrick Hogan, Gang Han, and Yubin Zhou

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Venous-derived angioblasts generate organ-specific vessels during embryonic development, Gideon Hen, Julian Nicenboim, Oded Mayseless, Lihee Asaf, Masahiro Shin, Giorgia Busolin, Roy Hofi, Gabriella Almog, Natascia Tiso, Nathan D. Lawson, and Karina Yaniv

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An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments, Erin E. Heyer, Hakan Ozadam, Emiliano P. Ricci, Can Cenik, and Melissa J. Moore

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Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease, Charis L. Himeda, Takako I. Jones, and Peter L. Jones

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DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients, Isabella C. Hirako, Carolina Gallego-Marin, Marco A. Ataide Oswalso Cruz Founda, Warrison A. Andrade, Humberto Gravina, Bruno C. Rocha, Rosane B. de Oliveira, Dhelio B. Pereira, Joseph Vinetz, Betty Diamond, Sanjay Ram, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement, Andrew G. Hoss, Adam Labadorf, Jeanne C. Latourelle, Vinay K. Kartha, Tiffany C. Hadzi, James F. Gusella, Marcy E. MacDonald, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Jean Paul Vonsattel, and Richard H. Myers

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Evaluating the QUIT-PRIMO clinical practice ePortal to increase smoker engagement with online cessation interventions: a national hybrid type 2 implementation study, Thomas K. Houston, Rajani S. Sadasivam, Jeroan J. Allison, Arlene S. Ash, Midge N. Ray, Thomas M. English, Timothy P. Hogan, and Daniel E. Ford

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Impact of Thromboprophylaxis across the US Acute Care Setting, Wei Huang, Frederick A. Anderson Jr., Sophie K. Rushton-Smith, and Alexander T. Cohen

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Comparative Genomics Reveals Chd1 as a Determinant of Nucleosome Spacing in Vivo, Amanda Hughes and Oliver J. Rando

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Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms, Eric Huseby, Daisuke Kamimura, Yasunobu Arima, Caitlin S. Parello, Katsuhiro Sasaki, and Masaaki Murakami

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Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6, Yu-Jie Hu, Houda Belaghzal, Wen-Yu Hsiao, Jun Qi, James E. Bradner, David A. Guertin, Said Sif, and Anthony N. Imbalzano

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Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila, Seol Hee Im, Kendra Takle, Juyeon Jo, Daniel T. Babcock, Zhiguo Ma, Yang Xiang, and Michael J. Galko

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Neutrophil Responses to Sterile Implant Materials, Siddharth Jhunjhunwala, Stephanie Aresta-DaSilva, Katherine Tang, David Alvarez, Matthew J. Webber, Benjamin C. Tang, Danya M. Lavin, Omid Veiseh, Joshua C. Doloff, Suman Bose, Arturo Vegas, Minglin Ma, Gaurav Sahay, Alan Chiu, Andrew Bader, Erin Langan, Sean Siebert, Jie Li, Dale L. Greiner, Peter E. Newburger, Ulrich H. von Andrian, Robert Langer, and Daniel G. Anderson

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The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens, Xincai Ji, Sucharita Saha, and Gilles E. Martin

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Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy, Takako I. Jones, Oliver D. King, Charis L. Himeda, Sachiko Homma, Jennifer C. J. Chen, Mary Lou. Beermann, Chi Yan, Charles P. Emerson Jr., Jeffrey B. Miller, Kathryn R. Wagner, and Peter L. Jones

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Feasibility, acceptability, and characteristics associated with adherence and completion of a culturally relevant internet-enhanced physical activity pilot intervention for overweight and obese young adult African American women enrolled in college, Rodney P. Joseph, Gareth R. Dutton, Andrea Cherrington, Kevin Fontaine, Monica Baskin, Krista Casazza, Danielle Lorch, Jeroan J. Allison, and Nefertiti H. Durant

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Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination, Tatenda Kadungure, Anna J. Ucher, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3, Seokwon Kang, Teresa Fernandes-Alnemri, Corey Rogers, Lindsey Mayes, Ying Wang, Christopher P. Dillon, Linda Roback, William Kaiser, Andrew Oberst, Junji Sagara, Katherine A. Fitzgerald, Douglas R. Green, Jianke Zhang, Edward S. Mocarski, and Emad S. Alnemri

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Techniques in distal access of wide-necked giant intracranial aneurysms during treatment with flow diversion, Peter Kan, Ajay K. Wakhloo, Maxim Mokin, and Ajit Puri

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Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo, Georg Karpel-Massler, Chang Shu, Lily Chau, Matei Banu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Yulian P. Ramirez, Alonzo H. Ross, Jeffrey N. Bruce, Peter Canoll, and Markus D. Siegelin

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Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells, Lyne Khair, Richard E. Baker, Erin K. Linehan, Carol E. Schrader, and Janet Stavnezer

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Palliative care in gynecological cancer, Shelley M. Kibel and Joanna M. Cain

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Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria, Karen J. Kieser, Cara C. Boutte, Jemila C. Kester, Christina E. Baer, Amy K. Barczak, Xavier Meniche, Michael C. Chao, E Hesper Rego, Christopher M. Sassetti, Sarah M. Fortune, and Eric J. Rubin

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The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum, Young-Hyun Kim, Myoung Lae Cho, Dan-Bi Kim, Gi-Hae Shin, Jin-Ha Lee, Jong Seok Lee, Sun-Ok Park, Sang-Jong Lee, Hyun Mu Shin, and Ok-Hwan Lee

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Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy, Shannon R.M. Kinney, Logan Carlson, Jennifer Ser-Dolansky, Chelsea Thompson, Sagar Shah, Amos Gambrah, Wei Xing, Sallie S. Schneider, and Clinton B. Mathias

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Evaluation of Cardiac Involvement in Children with Dengue by Serial Echocardiographic Studies, Tawatchai Kirawittaya, In-Kyu Yoon, Sineewanlaya Wichit, Sharone Green, Francis A. Ennis, Robert V. Gibbons, Stephen J. Thomas, Alan L. Rothman, Siripen Kalayanarooj, and Anon Srikiatkhachorn

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Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes, Marloes Kleinjan, Rutger C.M.E. Engels, and Joseph R. DiFranza

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The genetics of hepatitis C virus underlie its ability to escape humoral immunity, Jay K. Kolls and Gyongyi Szabo

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Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use, Anupam Kotwal and Sarah L. Cutrona

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Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas, Tomohiro Kubo, Masafumi Hirono, Takumi Aikawa, Ritsu Kamiya, and George B. Witman

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Preliminary Evaluation of a New German Translated Tobacco Quality of Life Impact Tool to Discriminate Between Healthy Current and Former Smokers and to Explore the Effect of Switching Smokers to a Reduced Toxicant Prototype Cigarette, Anuradha Kulasekaran, Christopher Proctor, Ermioni Papadopoulou, Christopher J. Shepperd, Rick Guyer, Barbara Gandek, and John E. Ware Jr.

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Acute symptomatic sinus bradycardia in a woman treated with pulse dose steroids for multiple sclerosis: a case report, Amartya Kundu and Timothy P. Fitzgibbons

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Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease, Braden Kuo, Manoj Bhasin, Jolene Jacquart, Matthew A. Scult, Lauren Slipp, Eric Isaac Riklin Kagan, Veronique Lepoutre, Nicole Comosa, Beth-Ann Norton, Allison Dassatti, Jessica Rosenblum, Andrea H. Thurler, Brian C. Surjanhata, Nicole N. Hasheminejad, Leslee Kagan, Ellen Slawsby, Sowmya R. Rao, Eric A. Macklin, Gregory L. Fricchione, Herbert Benson, Towia A. Libermann, Joshua Korzenik, and John W. Denninger

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RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression, Adam Labadorf, Andrew Hoss, Valentina Lagomarsino, Jeanne C. Latourelle, Tiffany C. Hadzi, Joli Bregu, Marcy E. MacDonald, James F. Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, and Richard H. Myers

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p53 protects against genome instability following centriole duplication failure, Bramwell G. Lambrus, Yumi Uetake, Kevin M. Clutario, Vikas Daggubati, Michael Snyder, Greenfield Sluder, and Andrew J. Holland

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Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys, Thuy Lam, Paige L. Williams, Mary M. Lee, Susan A. Korrick, Linda S. Birnbaum, Jane S. Burns, Oleg Sergeyev, Boris Revich, Larisa M. Altshul, Donald G. Patterson Jr, and Russ Hauser

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TRIM5 retroviral restriction activity correlates with the ability to induce innate immune signaling, Josefina Lascano, Pradeep Uchil, Walther Mothes, and Jeremy Luban

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Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium, Louise C. Laurent, Asim B. Abdel-Mageed, P. David Adelson, Jorge Arango, Leonora Balaj, Xandra Breakefield, Elizabeth Carlson, Bob S. Carter, Blanca Majem, Clark C. Chen, Emanuele Cocucci, Kirsty Danielson, Amanda Courtright, Saumya Das, Zakaria Y. Abd Elmageed, Daniel Enderle, Alan Ezrin, Marc Ferrer, Jane Freedman, and Kahraman Tanriverdi

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Differential Adjuvant Activities of TLR7 and TLR9 Agonists Inversely Correlate with Nitric Oxide and PGE2 Production, Jinhee Lee, Nuria Martinez, Kim West, and Hardy Kornfeld

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The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever, Daniel H. Libraty, Pengyan Wang, Zhiru Guo, Venelle Bigcas, Job D. Brion, and Rosario Z. Capeding

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Influenza virus infections in the tropics during the first year of life, Daniel H. Libraty, Lei Zhang, Mercydina Caponpon, and Rosario Z. Capeding

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Comparison between Frailty Index of Deficit Accumulation and Phenotypic Model to Predict Risk of Falls: Data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton Cohort, Guowei Li, Lehana Thabane, George Ioannidis, Courtney Kennedy, Alexandra Papaioannou, and Jonathan D. Adachi

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Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics, Junfeng Li, Zhaoyun Zhang, Xiaoxia Liu, Yi Wang, Fei Mao, Junjun Mao, Xiaolan Lu, Dongdong Jiang, Yun Wan, Jia-Ying Lv, Guoying Cao, Jing Zhang, Naiqing Zhao, Mark Atkinson, Dale L. Greiner, Gerald J. Prud'homme, Zheng Jiao, Yiming Li, and Qinghua Wang

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Current questions and possible controversies in autophagy, L M. Lindqvist, A K. Simon, and Eric H. Baehrecke

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Frequent Emergency Department Visits and Hospitalizations Among Homeless People With Medicaid: Implications for Medicaid Expansion, Wen-Chieh Lin, Monica Bharel, Jianying Zhang, Elizabeth O'Connell, and Robin E. Clark

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A versatile reporter system for CRISPR-mediated chromosomal rearrangements, Yingxiang Li, Angela I. Park, Haiwei Mou, Cansu Colpan, Aizhan Bizhanova, Elliot Akama-Garren, Nik Joshi, Eric A. Hendrickson, David Feldser, Hao Yin, Daniel G. Anderson, Tyler Jacks, Zhiping Weng, and Wen Xue

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Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps, Flavio V. Loures, Marc Rohm, Chrono K. Lee, Evelyn Santos, Jennifer P. Wang, Charles A. Specht, Vera L.G. Calich, Constantin F. Urban, and Stuart M. Levitz

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Breast Reconstruction: Closing the Loop after Breast Cancer, Jorge R. Lujan-Hernandez, Mauricio Perez Martinez, and Janice F. Lalikos

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Age at first intercourse and subsequent sexual partnering among adult women in the United States, a cross-sectional study, Brianna M. Magnusson, Jennifer A. Nield, and Kate L. Lapane

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Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection, Shivani Mahajan, Jessica Crisci, Alex Wong, Schahram Akbarian, Matthieu Foll, and Jeffrey D. Jensen

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ERbeta regulation of NF-kB activation in prostate cancer is mediated by HIF-1, Paul Mak, Jiarong Li, Sanjoy Samanta, and Arthur M. Mercurio

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Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains, Karim Malki, Yann Mineur, Maria Grazia Tosto, James Campbell, Priya Karia, Irfan Jumabhoy, Frans Sluyter, Wim E. Crusio, and Leonard C. Schalkwyk

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Migraine: treatments, comorbidities, and quality of life, in the USA, Christopher D. Malone, Amrita Bhowmick, and Amy B. Wachholtz

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Mesoscopic patterns of neural activity support songbird cortical sequences, Jeffrey E. Markowitz, William A. Liberti III, Grigori Guitchounts, Tarciso Velho, Carlos Lois, and Timothy J. Gardner

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Symptom severity of bipolar disorder during the menopausal transition, Wendy K. Marsh, Bernice G. Gershenson, and Anthony J. Rothschild

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Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival, Shan Ma, Aditya Venkatesh, Fernanda Langellotto, Yun Z. Le, Michael N. Hall, Markus A. Ruegg, and Claudio Punzo

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Knowledge on HPV Vaccine and Cervical Cancer Facilitates Vaccine Acceptability among School Teachers in Kitui County, Kenya, Moses Muia Masika, Javier Gordon Ogembo, Sophie Vusha Chabeda, Richard G. Wamai, and Nelly Mugo

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Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium, H. Matsumoto, Y. Murakami, K. Kataoka, S. Notomi, D. Mantopoulos, G. Trichonas, J. W. Miller, M. S. Gregory, B R. Ksander, Ann Marshak-Rothstein, and D. G. Vavvas

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Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea, Helen L. May-Simera, Ronald S. Petralia, Mireille Montcouquiol, Ya-Xian Wang, Katherine B. Szarama, Yun Liu, Weichun Lin, Michael R. Deans, Gregory J. Pazour, and Matthew W. Kelley

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The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women, Ryan McClure, Kathleen Nudel, Paola Massari, Brian Tjaden, Xiaohong Su, Peter A. Rice, and Caroline A. Genco

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Murine immune responses to virus-like particle-associated pre- and postfusion forms of the respiratory syncytial virus F protein, Lori McGinnes Cullen, Madelyn R. Schmidt, Sarah A. Kenward, Robert T. Woodland, and Trudy G. Morrison

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Preliminary needs assessment of mobile technology use for healthcare among homeless veterans, D. Keith McInnes, Gemmae M. Fix, Jeffrey L. Solomon, Beth Ann Petrakis, Leon Sawh, and David A. Smelson

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CFAP54 is required for proper ciliary motility and assembly of the central pair apparatus in mice, Casey W. McKenzie, Branch Craige, Tiffany V. Kroeger, Rozzy Finn, Todd A. Wyatt, Joseph H. Sisson, Jacqueline A. Pavlik, Lara Strittmatter, Gregory M. Hendricks, George B. Witman, and Lance Lee

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Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity, David M. Mofford, Spencer T. Adams Jr, G. S. Kiran Kumar Reddy, Gadarla Randheer Reddy, and Stephen C. Miller

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Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS, Fatemeh Momen-Heravi, Shashi Bala, Karen Kodys, and Gyongyi Szabo

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Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, and Gyongyi Szabo

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Understanding multifactorial influences on the continuum of maternal weight trajectories in pregnancy and early postpartum: study protocol, and participant baseline characteristics, Tiffany A. Moore Simas, Silvia Corvera, Mary M. Lee, Ningning Zhang, Katherine Leung, Barbara C. Olendzki, Bruce A. Barton, and Milagros C. Rosal

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Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors, Munemasa Mori, John E. Mahoney, Maria R. Stupnikov, Jesus R. Paez-Cortez, Aleksander D. Szymaniak, Xaralabos Varelas, Dan B. Herrick, James Schwob, Hong Zhang, and Wellington V. Cardoso

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Protein conformation in a vaccine matters, Trudy G. Morrison

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HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages, Thomas A. Musich, Olivia O'Connell, Maria Paz Gonzalez-Perez, Cynthia A. Derdeyn, Paul J. Peters, and Paul R. Clapham

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Role of Energy Metabolism in the Brown Fat Gene Program, Minwoo Nam and Marcus P. Cooper

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Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities, Kamesh Narasimhan, Samuel A. Lambert, Ally Yang, Jeremy Riddell, Sanie Mnaimneh, Hong Zheng, Mihai Albu, Hamed S. Najafabadi, John S. Reece-Hoyes, Juan Fuxman Bass, Albertha J. M. Walhout, Matthew T. Weirauch, and Timothy R. Hughes

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Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila, Yingchao Nie, Qi Li, Alla Amcheslavsky, Juan Carlos Duhart, Alexey Veraksa, Hugo Stocker, Laurel A. Raftery, and Y. Tony Ip

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Introduction: Advances and trends in image formation in X-ray computed tomography, Frederic Noo and Andrew Karellas

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Ultrasonography of intrauterine devices, Kristina M. Nowitzki, Matthew L. Hoimes, Byron Chen, Larry Zheng, and Young H. Kim

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Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen M. Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik N. Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, and Samuel M. Behar

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A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes, Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Lisa Greenman, Jody Fleshman, Nancy McShea, Bruce A. Barton, and Mary M. Lee

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A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, and Joyce D. Fingeroth

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Prevalence of Human Papillomavirus Genotypes among African Women with Normal Cervical Cytology and Neoplasia: A Systematic Review and Meta-Analysis, Rebecca Kemunto Ogembo, Philimon Gona, Alaina J. Seymour, Henry Soo-Min Park, Paul A. Bain, Louise Maranda, and Javier Gordon Ogembo

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Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels, Kelly H. Oh, Linu S. Abraham, Chandler Gegg, Christian Silvestri, Yung-Chi Huang, Mark J. Alkema, Jacob Furst, Daniela Raicu, and Hongkyun Kim

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Guanabenz (Wytensin) selectively enhances uptake and efficacy of hydrophobically modified siRNAs, Maire F. Osborn, Julia F. Alterman, Mehran Nikan, Hong Cao, Marie C. Didiot, Matthew R. Hassler, Andrew H. Coles, and Anastasia Khvorova

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Twitter-Delivered Behavioral Weight-Loss Interventions: A Pilot Series, Sherry L. Pagoto, Molly E. Waring, Kristin L. Schneider, Jessica L. Oleski, Effie Olendzki, Rashelle B. Hayes, Bradley M. Appelhans, Matthew C. Whited, Andrew M. Busch, and Stephenie C. Lemon

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Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis, Anil A. Panackal, Stuart M. Levitz, Bibi Bielekova, and Peter R. Williamson

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Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding, Ruimin Pan, Yuxin Chen, Michael Vaine, Guangnan Hu, Shixia Wang, Shan Lu, and Xiang-Peng Kong