PubMed ID

14561697

UMMS Affiliation

Division of Infectious Diseases and Immunology

Date

10-17-2003

Document Type

Article

Subjects

Animals; Membrane Glycoproteins; Mice; NADPH Oxidase; Neutrophils; Receptors, Cell Surface; Toll-Like Receptor 2; Toll-Like Receptors

Disciplines

Immunology and Infectious Disease

Abstract

Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.

Rights and Permissions

Citation: J Clin Invest. 2003 Oct;112(8):1136-7. Link to article on publisher's site

Related Resources

Link to Article in PubMed