PubMed ID
14561697
UMMS Affiliation
Division of Infectious Diseases and Immunology
Date
10-17-2003
Document Type
Article
Subjects
Animals; Membrane Glycoproteins; Mice; NADPH Oxidase; Neutrophils; Receptors, Cell Surface; Toll-Like Receptor 2; Toll-Like Receptors
Disciplines
Immunology and Infectious Disease
Abstract
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.
Rights and Permissions
Citation: J Clin Invest. 2003 Oct;112(8):1136-7. Link to article on publisher's site