UMMS Affiliation

Center for Infectious Disease and Vaccine Research



Document Type



Dengue; Dengue Virus; Humans; Immune System; Vaccines


Clinical Epidemiology | Immunology and Infectious Disease | Pharmacy and Pharmaceutical Sciences


Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.

Rights and Permissions

Citation: J Clin Invest. 2004 Apr;113(7):946-51. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID




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