UMMS Affiliation

Center for Infectious Disease and Vaccine Research

Publication Date


Document Type



Dengue; Dengue Virus; Humans; Immune System; Vaccines


Clinical Epidemiology | Immunology and Infectious Disease | Pharmacy and Pharmaceutical Sciences


Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.

Rights and Permissions

Citation: J Clin Invest. 2004 Apr;113(7):946-51. Link to article on publisher's site

DOI of Published Version


Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The Journal of clinical investigation

PubMed ID




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.