PubMed ID
15057297
UMMS Affiliation
Center for Infectious Disease and Vaccine Research
Date
4-2-2004
Document Type
Article
Subjects
Dengue; Dengue Virus; Humans; Immune System; Vaccines
Disciplines
Clinical Epidemiology | Immunology and Infectious Disease | Pharmacy and Pharmaceutical Sciences
Abstract
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
Rights and Permissions
Citation: J Clin Invest. 2004 Apr;113(7):946-51. Link to article on publisher's site
Related Resources
Included in
Clinical Epidemiology Commons, Immunology and Infectious Disease Commons, Pharmacy and Pharmaceutical Sciences Commons