UMMS Affiliation

Department of Pathology; Department of Molecular Genetics and Microbiology

Date

10-7-2004

Document Type

Article

Subjects

Animals; Antibodies, Viral; Humans; Membrane Glycoproteins; Mice; Neutralization Tests; RNA, Viral; Viral Envelope Proteins; Virion

Disciplines

Medical Pathology | Microbiology | Molecular Genetics

Abstract

The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.

Rights and Permissions

Citation: J Clin Invest. 2004 Oct;114(7):895-7. Link to article on publisher's site

DOI of Published Version

10.1172/JCI23098

Related Resources

Link to Article in PubMed

Journal Title

The Journal of clinical investigation

PubMed ID

15467827

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