Document Type
Journal ArticlePublication Date
2004-10-07Keywords
AnimalsAntibodies, Viral
Humans
Membrane Glycoproteins
Mice
Neutralization Tests
RNA, Viral
Viral Envelope Proteins
Virion
Medical Pathology
Microbiology
Molecular Genetics
Metadata
Show full item recordAbstract
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.Source
J Clin Invest. 2004 Oct;114(7):895-7. Link to article on publisher's siteDOI
10.1172/JCI23098Permanent Link to this Item
http://hdl.handle.net/20.500.14038/42670PubMed ID
15467827Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1172/JCI23098