Department of Pathology; Department of Molecular Genetics and Microbiology
Animals; Antibodies, Viral; Humans; Membrane Glycoproteins; Mice; Neutralization Tests; RNA, Viral; Viral Envelope Proteins; Virion
Medical Pathology | Microbiology | Molecular Genetics
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
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Citation: J Clin Invest. 2004 Oct;114(7):895-7. Link to article on publisher's site
DOI of Published Version
The Journal of clinical investigation
Szomolanyi-Tsuda, Eva and Welsh, Raymond M., "Judging a virus by its cover" (2004). Open Access Articles. 997.