Title

Diet and sex hormone-binding globulin

UMMS Affiliation

University of Massachusetts Medical School

Date

1-14-2000

Document Type

Article

Subjects

Adult; Aged; Alcohol Drinking; Cross-Sectional Studies; *Diet; Estradiol; Humans; Male; Massachusetts; Middle Aged; Regression Analysis; Sex Hormone-Binding Globulin

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The serum concentration of sex hormone-binding globulin (SHBG) is inversely related to weight and in animal studies is inversely related to protein intake. As SHBG can affect the biological activity of testosterone and estradiol, we wished to determine the role of protein intake on SHBG levels in men. Using data from the Massachusetts Male Aging Study we examined cross-sectional relationships between dietary components and SHBG levels in 1552 men (aged 40-70 yr) for whom these factors were known. Analyzed by multiple regression, controlling for testosterone and estradiol levels, age (P<0.001) and fiber intake (P = 0.02) were positively correlated to SHBG concentration, whereas body mass index (P<0.001) and protein intake (P<0.03) were negatively correlated to SHBG concentration. The intakes of calories, fat (animal or vegetable), and carbohydrate were not related to SHBG concentration. We conclude that age and body mass index are major determinants of SHBG concentrations in older men, and fiber and protein intake are also significant contributors to SHBG levels, but total caloric intake and the intake of carbohydrate or fat are not significant. Thus, diets low in protein in elderly men may lead to elevated SHBG levels and decreased testosterone bioactivity. The decrease in bioavailable testosterone can then result in declines in sexual function and muscle and red cell mass, and contribute to the loss of bone density.

Rights and Permissions

Citation: J Clin Endocrinol Metab. 2000 Jan;85(1):293-6.

Related Resources

Link to Article in PubMed

Journal Title

The Journal of clinical endocrinology and metabolism

PubMed ID

10634401