Title

Lithium dramatically potentiates neurotensin/neuromedin N gene expression

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date

10-5-1988

Document Type

Article

Subjects

Adrenal Gland Neoplasms; Animals; Cell Line; Chlorides; Dexamethasone; Forskolin; Genes; Kinetics; Lithium; Lithium Chloride; Nerve Growth Factors; Neurotensin; Peptide Fragments; Pheochromocytoma; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Lithium perturbs intracellular signal transduction pathways used by neurotransmitters, suggesting that changes in receptor signalling may underlie its actions in the treatment of manic depressive illness. Little attention, however, has been directed toward possible additional actions at the level of specific gene expression, particularly of genes encoding neurotransmitters or neuromodulators. In PC12 pheochromocytoma cells, lithium dramatically potentiates increases in intracellular levels of the neuropeptide neurotensin and the mRNA encoding it, caused by combinations of nerve growth factor, dexamethasone, and the adenylate cyclase activator, forskolin. This result demonstrates that lithium can profoundly influence the expression of a specific neuropeptide gene in a previously unanticipated manner and suggests that changes in gene expression might be involved in its therapeutic activity.

Rights and Permissions

Citation: J Biol Chem. 1988 Oct 5;263(28):13983-6.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The Journal of biological chemistry

PubMed ID

2844750