Title

Phage lambda red-mediated adaptive mutation

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date

6-12-2002

Document Type

Article

Subjects

Adaptation, Physiological; Bacteriophage lambda; Chromosomes, Bacterial; Escherichia coli; Lac Operon; *Mutation; *Recombination, Genetic; Transformation, Bacterial

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Replacement of the recBCD genes of Escherichia coli with the red recombination genes of bacteriophage lambda results in a strain in which adaptive mutation occurs at an elevated frequency. Like RecBCD-dependent adaptive mutation, Red-mediated adaptive mutation is dependent upon recA and ruvABC functions.

Rights and Permissions

Citation: J Bacteriol. 2002 Jul;184(13):3753-5.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of bacteriology

PubMed ID

12057974