Title

Value of dual-energy CT in differentiating focal fatty infiltration of the liver from low-density masses

UMMS Affiliation

Department of Radiology; Department of Urology; Division of Gastroenterology; Department of Pathology

Publication Date

10-1-1991

Document Type

Article

Subjects

Adult; Diagnosis, Differential; Evaluation Studies; Fatty Liver; Female; Hemochromatosis; Hemosiderosis; Humans; Liver Neoplasms; Male; Middle Aged; *Radiography, Dual-Energy Scanned Projection; Tomography, X-Ray Computed

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Focal (irregular, partial) fatty infiltration of the liver may simulate neoplastic or other hypodense masses on CT. On the basis of previous observations of the phenomenon that differences in X-ray attenuation diminish with increasing energy of X-rays used, we performed a preliminary study to determine if dual-energy CT could be used to discriminate between fatty infiltration and hypodense liver masses. Dual-energy CT at 140 and 80 kVp was performed in 14 patients undergoing liver biopsy and in seven control subjects with presumedly normal liver. Attenuation measurements were taken, and the changes in attenuation between 140 and 80 kVp were calculated. The mean changes in attenuation were 3.5 H for normal liver (n = 7), 2.5 H for hypodense liver masses (n = 6), 13 H for fatty liver (n = 5), 0.3 H for fatty liver combined with hemochromatosis or hemosiderosis (n = 3), and 2 H for the spleen (n = 18). The change in attenuation increased as the fat content in the liver increased. Analysis of variance showed a statistically significant difference (p less than .001) between fatty liver and the other groups. A difference greater than 10 H was unique to fatty infiltration. These results suggest that dual-energy CT may help to differentiate focal fatty infiltration of the liver from low-density neoplastic or other lesions, but only if the iron content of the liver is not increased.

Rights and Permissions

Citation: AJR Am J Roentgenol. 1991 Oct;157(4):721-5.

DOI of Published Version

10.2214/ajr.157.4.1892025

Related Resources

Link to article in PubMed

Journal/Book/Conference Title

AJR. American journal of roentgenology

PubMed ID

1892025