Title

A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator

UMMS Affiliation

Howard Hughes Medical Institute; Program in Molecular Medicine; Program in Gene Function and Expression

Publication Date

February 1996

Document Type

Article

Subjects

Adolescent; Aged; Amino Acid Sequence; Animals; Base Sequence; Child, Preschool; Drosophila; Female; Hela Cells; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mitogens; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Serine-Threonine Kinases; purification; Recombinant Fusion Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Although the ultimate targets of many signal transduction pathways are nuclear transcription factors, the vast majority of known protein kinases are cytosolic. Here, we report on a novel human kinase that is present exclusively in the nucleus. Kinase activity is increased upon cellular proliferation and is markedly elevated in patients with acute and chronic lymphocytic leukemias. We have identified a human gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity. Collectively, these results suggest that this nuclear kinase is a component of a signal transduction pathway that plays a role in Drosophila development and human growth control.

Rights and Permissions

Citation: Genes Dev. 1996 Feb 1;10(3):261-71.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Genes and development

PubMed ID

8595877

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