Title

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

UMMS Affiliation

Howard Hughes Medical Institute and Program in Molecular Medicine; Department of Cancer Biology; Department of Medicine, Division of Diabetes; Department of Pathology

Publication Date

9-20-2001

Document Type

Article

Subjects

*Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carrier Proteins; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Neurons; *Oxidative Stress

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.

Rights and Permissions

Citation: Genes Dev. 2001 Sep 15;15(18):2421-32. Link to article on publisher's site

DOI of Published Version

10.1101/gad.922801

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Genes and development

PubMed ID

11562351