An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

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Howard Hughes Medical Institute and Program in Molecular Medicine

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*Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Diet; Enzyme Activation; Insulin Resistance; *JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Nuclear Proteins; Trans-Activators


Life Sciences | Medicine and Health Sciences


The c-Jun NH2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits signaling by the insulin receptor. JNK can therefore cause peripheral insulin resistance during obesity and may contribute to the development of type 2 diabetes. Here we report that the JNK-interacting protein 1 (JIP1) scaffold protein, which binds components of the JNK signaling module, is essential for JNK activation in the adipose tissue of obese mice. These data identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity.

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Citation: Genes Dev. 2004 Aug 15;18(16):1976-80. Link to article on publisher's site

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Genes and development

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