Title

Perspective: machines for RNAi

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

3-3-2005

Document Type

Article

Subjects

Animals; Down-Regulation; Humans; Protein Biosynthesis; RNA Stability; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins; Signal Transduction; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into approximately 21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA transcription or translation, or catalyze mRNA destruction. Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression.

Rights and Permissions

Citation: Genes Dev. 2005 Mar 1;19(5):517-29. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

15741316