Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials
Authors
Leitner, Melanie L.Kapur, Kush
Darras, Basil T.
Yang, Michele
Wong, Brenda L
Dalle Pazze, Laura
Florence, Julaine
Buck, Martin
Freedman, Laura
Bohorquez, Jose
Rutkove, Seward
Zaidman, Craig
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2019-12-25Keywords
electrical impedance myographyDuchenne muscular dystrophy
clinical trials
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Diagnosis
Musculoskeletal Diseases
Nervous System Diseases
Neurology
Translational Medical Research
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OBJECTIVE: To evaluate the sensitivity of electrical impedance myography (EIM) to disease progression in both ambulatory and non-ambulatory boys with DMD. METHODS AND PARTICIPANTS: A non-blinded, longitudinal cohort study of 29 ambulatory and 15 non-ambulatory boys with DMD and age-similar healthy boys. Subjects were followed for up to 1 year and assessed using the Myolex((R)) mView(TM) EIM system as part of a multicenter study. RESULTS: In the ambulatory group, EIM 100 kHz resistance values showed significant change compared to the healthy boys. For example, in lower extremity muscles, the average change in EIM 100 kHz resistance values over 12 months led to an estimated effect size of 1.58. Based on these results, 26 DMD patients/arm would be needed for a 12-month clinical trial assuming a 50% treatment effect. In non-ambulatory boys, EIM changes were greater in upper limb muscles. For example, biceps at 100kHz resistance gave an estimated effect size of 1.92 at 12 months. Based on these results, 18 non-ambulatory DMD patients/arm would be needed for a 12-month clinical trial assuming a 50% treatment effect. Longitudinal changes in the 100 kHz resistance values for the ambulatory boys correlated with the longitudinal changes in the timed supine-to-stand test. EIM was well-tolerated throughout the study. INTERPRETATION: This study supports that EIM 100 kHz resistance is sensitive to DMD progression in both ambulatory and non-ambulatory boys. Given the technology's ease of use and broad age range of utility it should be employed as an exploratory endpoint in future clinical therapeutic trials in DMD. TRIAL REGISTRATION: Clincialtrials.gov registration #NCT02340923.Source
Ann Clin Transl Neurol. 2019 Dec 25. doi: 10.1002/acn3.50958. [Epub ahead of print] Link to article on publisher's site
DOI
10.1002/acn3.50958Permanent Link to this Item
http://hdl.handle.net/20.500.14038/41294PubMed ID
31876124Related Resources
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© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.Distribution License
http://creativecommons.org/licenses/by-nc-nd/4.0/ae974a485f413a2113503eed53cd6c53
10.1002/acn3.50958
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Except where otherwise noted, this item's license is described as © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.