Title

Side effects with inhaled corticosteroids: the physician's perception

UMMS Affiliation

Department of Medicine, Division of Pulmonary, Allergy, and Critical Care

Date

7-15-2006

Document Type

Article

Subjects

Administration, Inhalation; Adult; Asthma; Attitude of Health Personnel; Child; Glucocorticoids; Humans; Metered Dose Inhalers

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The National Asthma Education and Prevention Program 1997 guidelines and 2002 update provide an overview of potential local and systemic side effects associated with inhaled corticosteroids (ICS) and suggest ways of minimizing the risk of these side effects occurring. Despite the guidelines and extensive clinical experience of the safe use of ICS, a significant number of physicians retain concerns regarding side effects. Local side effects may lead to patients discontinuing therapy, with or without the knowledge of their physicians. In particular, concerns regarding systemic side effects, such as growth retardation in children and osteoporosis, remain relatively widespread. Pharmacokinetic studies reveal that different ICS compounds and formulations result in different degrees of systemic bioavailability, indicating possible differences in their potential to cause systemic side effects. However, clinical studies that can be used to differentiate between ICS formulations are generally lacking. Consequently, there is a need to continue to further our understanding of side effects with ICS, with the aim of identifying formulations, devices, and doses with an optimal risk/benefit ratio. The introduction of new agents with potentially improved safety profiles may reassure physicians and patients as to the relative benefits of ICS therapy in asthma.

Rights and Permissions

Citation: Chest. 2006 Jul;130(1 Suppl):41S-53S. Link to article on publisher's site

DOI of Published Version

10.1378/chest.130.1_suppl.41S

Related Resources

Link to article in PubMed

Journal Title

Chest

PubMed ID

16840367