Title

Coupling apoptosis resistance to the cellular stress response: the IAP-Hsp90 connection in cancer

UMMS Affiliation

Department of Cancer Biology and the Cancer Center

Date

1-17-2004

Document Type

Article

Subjects

Animals; *Apoptosis; HSP90 Heat-Shock Proteins; Humans; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasms; Protein Binding

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Understanding how tumor cells manage to survive and proliferate in ever-changing and often harmful microenvironments is a daunting challenge in tumor biology, and a major cause of treatment failure in the oncology clinic. Recent data have now demonstrated a direct link between the molecular chaperone Hsp90 and survivin, a dual regulator of cell proliferation and cell death over-expressed in virtually every human tumor. While the survivin-Hsp90 association may help tumor cells elevate their anti-apoptotic threshold and promote their proliferation, it may also provide new opportunities for rational cancer therapy.

Rights and Permissions

Citation: Cell Cycle. 2004 Mar;3(3):255-6. Epub 2004 Mar 1.

DOI of Published Version

10.4161/cc.3.3.711

Related Resources

Link to article in PubMed

Journal Title

Cell cycle (Georgetown, Tex.)

PubMed ID

14726679