Coupling apoptosis resistance to the cellular stress response: the IAP-Hsp90 connection in cancer

UMMS Affiliation

Department of Cancer Biology and the Cancer Center

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Animals; *Apoptosis; HSP90 Heat-Shock Proteins; Humans; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasms; Protein Binding


Life Sciences | Medicine and Health Sciences


Understanding how tumor cells manage to survive and proliferate in ever-changing and often harmful microenvironments is a daunting challenge in tumor biology, and a major cause of treatment failure in the oncology clinic. Recent data have now demonstrated a direct link between the molecular chaperone Hsp90 and survivin, a dual regulator of cell proliferation and cell death over-expressed in virtually every human tumor. While the survivin-Hsp90 association may help tumor cells elevate their anti-apoptotic threshold and promote their proliferation, it may also provide new opportunities for rational cancer therapy.

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Citation: Cell Cycle. 2004 Mar;3(3):255-6. Epub 2004 Mar 1.

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Link to article in PubMed

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

PubMed ID