Title

Mitochondrial dynamics of survivin and "four dimensional" control of tumor cell apoptosis

UMMS Affiliation

Department of Cancer Biology and the Cancer Center

Date

12-22-2004

Document Type

Article

Subjects

Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Mitochondria; Mitosis; Neoplasm Proteins; Neoplasms; Protein Transport; Signal Transduction

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The intense investigation of cell death pathways over the past few years has uncovered elevated complexity with panoply of molecular interactions, multiple intersecting gene networks and bidirectional crosstalk among disparate cellular regulators. What has remained more elusive is how these interactions are spatially arranged in the "four dimensions" of the cell as a whole, and their true relevance to human diseases. Fresh evidence obtained with survivin has unraveled a process of dynamic subcellular shuttling that is required to inhibit apoptosis during tumor growth, with the mitochondrion playing a central, orchestrating role.

Rights and Permissions

Citation: Cell Cycle. 2005 Jan;4(1):21-3. Epub 2005 Jan 12.

DOI of Published Version

10.4161/cc.4.1.1367

Related Resources

Link to article in PubMed

Journal Title

Cell cycle (Georgetown, Tex.)

PubMed ID

15611629