Title

Colorectal cancer progression: integrin alphavbeta6 and the epithelial-mesenchymal transition (EMT)

UMMS Affiliation

Department of Cancer Biology

Publication Date

8-27-2005

Document Type

Article

Subjects

Antigens, Neoplasm; Colorectal Neoplasms; Disease Progression; Epithelial Cells; Extracellular Matrix; Humans; Integrins; Mesoderm; Neoplasm Invasiveness

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Carcinomas, those tumors that arise from epithelial tissues, represent the most prevalent form of human malignancies. Moreover, it is the metastatic spread of these cancers, rather than the development of primary neoplasms that predominantly accounts for patient mortality. Thus, understanding the mechanisms that contribute to the process of cancer progression is of fundamental importance lo designing better therapeutic strategies for treating this disease. The epithelial-mesenchymal transition (EMT), which facilitates the process by which epithelial tumors become invasive and progress towards malignant disease, provides a superb paradigm for studying such mechanisms. Using a colon carcinoma model of EMT, it was discovered that increased expression of the integrin alphavbeta6 is elicited as a consequence of the transition. Importantly, the consequences of the elevated alphavbeta6 expression are directly linked to both tumor cell function and to the mechanism of the EMT itself. Most significantly increased alphavbeta6 expression in human tumors is a prognostic variable and one that is predictive of outcome for early-stage disease. These findings reinforce the importance of the EMT event in late stage tumorigenesis, and define alphavbeta6 as a novel therapeutic candidate for aggressive colorectal cancer.

Rights and Permissions

Citation: Cell Cycle. 2005 Oct;4(10):1350-2. Epub 2005 Oct 25.

Related Resources

Link to article in PubMed

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

PubMed ID

16123591