Switching on chromatin: mechanistic role of histone H4-K16 acetylation

UMMS Affiliation

Program in Molecular Medicine

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Document Type



Acetylation; Animals; Chromatin; Histones; Humans; Protein Binding; Transcription, Genetic


Life Sciences | Medicine and Health Sciences


How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.

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Citation: Cell Cycle. 2006 Jul;5(13):1361-5. Epub 2006 Jul 1.

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Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

PubMed ID