Title

Switching on chromatin: mechanistic role of histone H4-K16 acetylation

UMMS Affiliation

Program in Molecular Medicine

Publication Date

7-21-2006

Document Type

Article

Subjects

Acetylation; Animals; Chromatin; Histones; Humans; Protein Binding; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

How post-translational histone modifications regulate DNA utilization constitutes one of the central questions of chromatin biology. In studying the mechanistic role of histone H4-K16 acetylation, a mark with a functional role in maintaining transcriptionally permissive DNA domains or directly promoting gene transcription, we found that this acetylation both disrupts higher-order chromatin structure and changes the functional interaction of chromatin-associated proteins. The potential significance of this finding for in vivo chromatin structure, establishment of euchromatic domains, and promotion of gene transcription is examined.

Rights and Permissions

Citation: Cell Cycle. 2006 Jul;5(13):1361-5. Epub 2006 Jul 1.

Related Resources

Link to article in PubMed

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

PubMed ID

16855380