Listeria monocytogenes as a probe of immune function
Program in Gene Function and Expression
Animals; Complement C5; Genetics; Genome; Genomics; Humans; Immune System; Immunity, Active; Immunity, Natural; Listeria Infections; Listeria monocytogenes; Mice; Mutation; Oligonucleotide Array Sequence Analysis; Promoter Regions (Genetics); Signal Transduction; Transgenes; Variation (Genetics)
Life Sciences | Medicine and Health Sciences
For almost half a century, the mouse model of Listeria monocytogenes infection has been used to analyse both innate and adaptive components of immunity and to discover key immune genes. Vast accumulated knowledge about the disease in mice provides a unique framework for identifying and characterising immune molecules using a variety of experimental approaches. To illustrate the range of questions that can be addressed using modern genetics and genomics tools, the authors provide an overview of the analysis of components of immune signalling networks using the mouse model of L. monocytogenes infection.
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Citation: Brief Funct Genomic Proteomic. 2005 Nov;4(3):258-69.