Title

Cardioprotection with adenosine: 'a riddle wrapped in a mystery'

UMMS Affiliation

Department of Emergency Medicine; Department of Anesthesiology

Date

5-17-2005

Document Type

Article

Subjects

Adenosine; Animals; Cardiotonic Agents; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Rats

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.

Rights and Permissions

Citation: Br J Pharmacol. 2005 Jul;145(6):699-700. Link to article on publisher's site

DOI of Published Version

10.1038/sj.bjp.0706261

Related Resources

Link to article in PubMed

Journal Title

British journal of pharmacology

PubMed ID

15895103