Cardioprotection with adenosine: 'a riddle wrapped in a mystery'

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Department of Emergency Medicine; Department of Anesthesiology

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Adenosine; Animals; Cardiotonic Agents; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Rats


Life Sciences | Medicine and Health Sciences


Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.

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Citation: Br J Pharmacol. 2005 Jul;145(6):699-700. Link to article on publisher's site

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British journal of pharmacology

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