UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

1-11-2017

Document Type

Article

Disciplines

Biodiversity | Ecology and Evolutionary Biology | Microbiology

Abstract

Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using "Cryptococcus neoformans species complex" and "C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.

Rights and Permissions

Copyright © 2017 Kwon-Chung et al. Citation: mSphere. 2017 Jan 11;2(1). pii: e00357-16. eCollection 2017 Jan-Feb. Link to article on publisher's site

DOI of Published Version

10.1128/mSphere.00357-16

Comments

Full author list omitted for brevity. For the full list of authors, see article.

Related Resources

Link to Article in PubMed

Keywords

Cryptococcosis, Cryptococcus gattii, Cryptococcus neoformans, clade, genetic diversity, new nomenclature, species complex

Journal Title

mSphere

PubMed ID

28101535

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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