UMMS Affiliation

Medical Center of Central Massachusetts-Memorial; Division of Hematology and Oncology

Date

7-1-1990

Document Type

Article

Subjects

Adolescent; Adult; Aged; Blood Transfusion; Child; Child, Preschool; Cohort Studies; HIV Seropositivity; Hemophilia A; Hepatitis Antibodies; Hepatitis C; Hepatitis, Viral, Human; Humans; Middle Aged; Prevalence

Disciplines

Hematology | Oncology

Abstract

One hundred thirty-one patients followed at the New England Hemophilia Center (Worcester, MA) were tested for antibody to hepatitis C virus (HCV). All but two had used factor concentrate that had not undergone viral inactivation; two patients had used only cryoprecipitate. The overall prevalence of HCV antibody positivity was 76.3%. There was no significant difference in age or the amount of non-heat-treated factor concentrate used between the group that was HCV antibody positive and negative. There was also no significant difference between aminotransferase levels in the two groups. There was a positive association between HCV antibody and the presence of antibody to hepatitis B core antigen and antibody to human immunodeficiency virus. A group of 31 patients were tested twice for HCV antibody at intervals of 35 to 71 months. In this subset, 25 were repeatedly seropositive, 4 were repeatedly seronegative, and 2 went from seropositive to seronegative. These data confirm the previous impression that non-A, non-B hepatitis is a major sequela to the use of pooled coagulation factor concentrates. HCV infection may account for most of the chronic liver disease observed in this population. Anti-HCV testing of plasma donors and improved methods of viral inactivation should prevent new cases from developing.

Rights and Permissions

Citation: Blood. 1990 Jul 1;76(1):254-6.

Related Resources

Link to article in PubMed

Journal Title

Blood

PubMed ID

2114186

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.