UMMS Affiliation

Program in Molecular Medicine

Date

1-26-2017

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Cellular and Molecular Physiology

Abstract

Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.

Rights and Permissions

Citation: Sci Rep. 2017 Dec;7(1):1. doi: 10.1038/s41598-016-0028-x. Epub 2017 Jan 26. Link to article on publisher's site

DOI of Published Version

10.1038/s41598-016-0028-x

Related Resources

Link to Article in PubMed

Journal Title

Scientific reports

PubMed ID

28127051

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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