Program in Molecular Medicine
Glucan particles (GPs) are hollow, porous 3-5 mum microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-beta-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing beta-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.
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Copyright © 2016 Ernesto R. Soto et al. Citation: J Drug Deliv. 2016;2016:8520629. Epub 2016 Nov 14. Link to article on publisher's site
DOI of Published Version
Journal of drug delivery
Soto, Ernesto R.; O'Connell, Olivia; Dikengil, Fusun; Peters, Paul J.; Clapham, Paul R.; and Ostroff, Gary R., "Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages" (2016). Open Access Articles. 3006.
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