UMMS Affiliation

Program in Molecular Medicine

Date

12-14-2016

Document Type

Article

Disciplines

Therapeutics

Abstract

Glucan particles (GPs) are hollow, porous 3-5 mum microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-beta-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing beta-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encapsulated inside the hollow GPs or bound to the surface of chemically derivatized GPs. Gallium nanoparticles have been proposed as an inhibitory agent against HIV infection. Here, macrophage targeting of gallium using GPs provides for more efficient delivery of gallium and inhibition of HIV infection in macrophages compared to free gallium nanoparticles.

Rights and Permissions

Copyright © 2016 Ernesto R. Soto et al. Citation: J Drug Deliv. 2016;2016:8520629. Epub 2016 Nov 14. Link to article on publisher's site

DOI of Published Version

10.1155/2016/8520629

Related Resources

Link to Article in PubMed

Journal Title

Journal of drug delivery

PubMed ID

27965897

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Included in

Therapeutics Commons

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