UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

11-3-2016

Document Type

Article

Disciplines

Immunology and Infectious Disease | Parasitic Diseases | Parasitology

Abstract

Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.

Rights and Permissions

Citation: Nat Commun. 2016 Nov 3;7:13277. doi: 10.1038/ncomms13277. Link to article on publisher's site

DOI of Published Version

10.1038/ncomms13277

Related Resources

Link to Article in PubMed

Keywords

Antimicrobial responses, Parasite host response

Journal/Book/Conference Title

Nature communications

PubMed ID

27808089

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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