UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

11-3-2016

Document Type

Article

Disciplines

Immunology and Infectious Disease | Parasitic Diseases | Parasitology

Abstract

Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.

Rights and Permissions

Citation: Nat Commun. 2016 Nov 3;7:13277. doi: 10.1038/ncomms13277. Link to article on publisher's site

DOI of Published Version

10.1038/ncomms13277

Related Resources

Link to Article in PubMed

Keywords

Antimicrobial responses, Parasite host response

Journal Title

Nature communications

PubMed ID

27808089

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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