Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources
Authors
Shah, RaviTanriverdi, Kahraman
Levy, Daniel
Larson, Martin
Gerstein, Mark B.
Mick, Eric O.
Rozowsky, Joel
Kitchen, Robert
Murthy, Venkatesh
Mikalev, Ekaterina
Freedman, Jane E.
UMass Chan Affiliations
UMass Metabolic NetworkDepartment of Quantitative Health Sciences
Department of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2016-04-28Keywords
UMCCTS fundingMicroRNAs
Blood plasma
Blood
RNA isolation
Biomarkers
RNA sequencing
Gene expression
Gene regulation
Biological Factors
Genetic Processes
Medical Biochemistry
Nucleic Acids, Nucleotides, and Nucleosides
Metadata
Show full item recordAbstract
MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.Source
PLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016. Link to article on publisher's siteDOI
10.1371/journal.pone.0153691Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40107PubMed ID
27123852Related Resources
Link to Article in PubMedRights
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Distribution License
http://creativecommons.org/publicdomain/zero/1.0/ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0153691
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Except where otherwise noted, this item's license is described as This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.