UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences; UMass Metabolic Network

Date

4-28-2016

Document Type

Article

Disciplines

Biological Factors | Genetic Processes | Medical Biochemistry | Nucleic Acids, Nucleotides, and Nucleosides

Abstract

MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.

Rights and Permissions

Citation: PLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016. Link to article on publisher's site. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

DOI of Published Version

10.1371/journal.pone.0153691

Related Resources

Link to Article in PubMed

Keywords

UMCCTS funding, MicroRNAs, Blood plasma, Blood, RNA isolation, Biomarkers, RNA sequencing, Gene expression, Gene regulation

Journal Title

PloS one

PubMed ID

27123852

 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.