UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Graduate School of Biomedical Sciences, Program in Biochemistry and Molecular Pharmacology

Publication Date

5-9-2016

Document Type

Article

Disciplines

Biochemistry | Cell Biology | Molecular Biology

Abstract

Trafficking in eukaryotic cells is a tightly regulated process to ensure correct cargo delivery to the proper destination organelle or plasma membrane. In this review, we focus on how the vesicle fusion machinery, the SNARE complex, is regulated by the interplay of the multisubunit tethering complexes (MTC) with the SNAREs and Sec1/Munc18 (SM) proteins. Although these factors are used in different stages of membrane trafficking, e.g., Golgi to plasma membrane transport vs. vacuolar fusion, and in a variety of diverse eukaryotic cell types, many commonalities between their functions are being revealed. We explore the various protein-protein interactions and findings from functional reconstitution studies in order to highlight both their common features and the differences in their modes of regulation. These studies serve as a starting point for mechanistic explorations in other systems.

Rights and Permissions

Citation: Front Cell Dev Biol. 2016 May 9;4:42. doi: 10.3389/fcell.2016.00042. eCollection 2016. Link to article on publisher's site

DOI of Published Version

10.3389/fcell.2016.00042

Related Resources

Link to Article in PubMed

Keywords

SNARE complexes, Sec1/Munc18, intracellular trafficking, multisubunit tethering complexes

Journal/Book/Conference Title

Frontiers in cell and developmental biology

PubMed ID

27243006

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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