Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials
UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDocument Type
Journal ArticlePublication Date
2016-04-26
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Show full item recordAbstract
The regulation of cellular signaling in vivo has been a challenging task owing to the lack of effective methods for tunable control of the amplitude, location, and duration of cell-signaling events at a deep-tissue level. In this issue of ACS Nano, an intriguing paper by Ambrosone et al. demonstrates that deep-tissue-penetrating near-infrared (NIR) light can be used to control the Wnt/beta-catenin-signaling pathway in a single-cell organism (Hydra) by utilizing microcapsules that contain plasmonic gold nanoparticles. In parallel, in recent work, we proposed upconversion nanoparticles (UCNPs) as NIR-light-activatable "wireless" optogenetic tools, and we showed their ability to modulate cell signaling pathways in both mammalian cells and mice. We believe that these interesting NIR-light-responsive nanotechnologies will open new avenues for both basic research and clinical applications.Source
ACS Nano. 2016 Apr 26;10(4):3881-5. doi: 10.1021/acsnano.6b02284. Epub 2016 Apr 14. Link to article on publisher's siteDOI
10.1021/acsnano.6b02284Permanent Link to this Item
http://hdl.handle.net/20.500.14038/40046PubMed ID
27077481Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1021/acsnano.6b02284