UMMS Affiliation

Department of Microbiology and Physiological Systems

Publication Date

1-12-2016

Document Type

Article

Disciplines

Cell Biology | Developmental Biology | Immunity

Abstract

B cells are key components of cellular and humoral immunity and, like all lymphocytes, are thought to originate and renew from hematopoietic stem cells (HSCs). However, our recent single-HSC transfer studies demonstrate that adult bone marrow HSCs do not regenerate B-1a, a subset of tissue B cells required for protection against pneumonia, influenza, and other infections. Since B-1a are regenerated by transfers of fetal liver, the question arises as to whether B-1a derive from fetal, but not adult, HSCs. Here we show that, similar to adult HSCs, fetal HSCs selectively fail to regenerate B-1a. We also show that, in humanized mice, human fetal liver regenerates tissue B cells that are phenotypically similar to murine B-1a, raising the question of whether human HSC transplantation, the mainstay of such models, is sufficient to regenerate human B-1a. Thus, our studies overtly challenge the current paradigm that HSCs give rise to all components of the immune system.

Rights and Permissions

Citation: Stem Cell Reports. 2016 Jan 12;6(1):137-49. doi: 10.1016/j.stemcr.2015.11.011. Epub 2015 Dec 24. Link to article on publisher's site

Copyright © 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

DOI of Published Version

10.1016/j.stemcr.2015.11.011

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Stem cell reports

PubMed ID

26724903

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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